4-Thiazolecarboxylic acid, 2-bromo-5-methyl-, methyl ester

4-Thiazole carboxylic acid, 2-bromo-5-methyl-, methyl ester, the chemical structure of this compound is based on the thiazole ring. The thiazole ring is a five-membered heterocyclic ring containing sulfur and nitrogen. At the 4th position of the thiazole ring, there is a carboxyl methyl ester group, that is, the -COOCH group, which is the key part of the ester structure. At the 2nd position of the thiazole ring, there is a bromine atom, and at the 5th position, there is a methyl group. Overall, the compound takes the thiazole ring as the core structure and connects different substituents at specific positions to construct a unique chemical structure. The presence of bromine atoms, methyl groups, and methyl ester groups endows the compound with specific chemical properties and reactivity, making it useful in organic synthesis and related chemical fields.

4-Thiazolecarboxylic acid, 2-bromo-5-methyl-, methyl ester, this is an organic compound with specific physical properties. Looking at its properties, it is either solid or liquid at room temperature and pressure, but the specific shape depends on the actual conditions.
When it comes to the melting point, due to the lack of exact data, it can only be speculated that the intermolecular force, the symmetry and rigidity of the structure of this compound will affect the melting point. If the intermolecular force is strong and the structure is regular and orderly, the melting point may be relatively high; conversely, if the intermolecular force is weak and the structure is messy, the melting point may be low.
The boiling point is also restricted by a variety of factors. The larger the molecular mass, the stronger the intermolecular force, and the higher the boiling point is usually. At the same time, the polarity of the molecule is also affected. Molecules with high polarity tend to have higher boiling points due to strong dipole-dipole interactions.
Its solubility is related to the polar groups in the molecular structure. This compound contains thiazole ring, bromine atom, methyl and ester group. Thiazole ring is a heterocyclic ring containing sulfur and nitrogen, with a certain polarity; bromine atom is electronegative, which enhances the local polarity of the molecule; methyl is a non-polar group, and ester group also has a certain polarity. Overall, the compound may have some solubility in polar organic solvents such as ethanol and acetone; in polar non-solvents such as n-hexane, its solubility may be poor.
In addition, its density is also related to the molecular structure and composition. The type, number and arrangement of atoms in a molecule all affect the density. Due to the lack of measured data, it can only be speculated from theory that its density may be within the density range of common organic compounds.
The physical properties of this substance are of great significance in the fields of chemical synthesis and drug development. Only by clarifying its physical properties can we better control the reaction conditions and achieve efficient synthesis. In drug development, it can help predict the absorption, distribution, metabolism and excretion process of drugs in the body.

The common synthesis methods of 4-thiazole carboxylic acid, 2-bromo-5-methyl-, and methyl ester have the following numbers.
First, the compound containing the thiazole ring is used as the starting material. First, the appropriate thiazole derivative is taken and methyl is introduced at a specific position. This step can be catalyzed by a suitable alkylating agent, such as methyl halide, under the catalysis of a base. Bases, such as potassium carbonate and sodium hydroxide, can cause the hydrogen on the thiazole ring to leave, and then a substitution reaction occurs with the alkylating agent to achieve the modification of 5-methyl.
Then, bromine atoms are introduced at the 2-position of the thiazole ring. Commonly used brominating reagents, such as N-bromosuccinimide (NBS), can selectively brominate at the 2-position of the thiazole ring under the action of light or initiators. Initiators, such as azobisisobutyronitrile (AIBN), can generate active free radicals to promote the bromination reaction.
After the 2-position and 5-position of the thiazole ring have been modified, carboxyl groups can be esterified to obtain methyl esters. Thiazole compounds containing carboxyl groups can be mixed with methanol, and an appropriate amount of concentrated sulfuric acid can be added as a catalyst to heat and reflux to promote the esterification reaction. Concentrated sulfuric acid can protonate the carboxyl group and enhance its electrophilicity, so that it is easier to undergo nucleophilic substitution reaction with methanol to form the target 4-thiazolecarboxylic acid, 2-bromo-5-methyl-, methyl ester.
Second, you can also start from the construction of thiazole ring. The bifunctional compound containing sulfur and nitrogen and the appropriate carbonyl compound and bromomethyl reagent are used as raw materials. First, the bifunctional compound containing sulfur and nitrogen and the carbonyl compound are cyclized under suitable conditions to form a thiazole ring. The conditions of the cyclization reaction depend on the specific reactants, or are carried out by heating or in a specific solvent. Subsequently, on the formed thiazole ring, according to the above similar method, bromine atoms are introduced first, then methylation is carried out, and finally methylation of carboxyl groups is completed. In this way, the target product can also be obtained. These methods are all common ways to synthesize 4-thiazolecarboxylic acid, 2-bromo-5-methyl-, and methyl ester.

Methyl 2-bromo-5-methyl-4-thiazole carboxylate, this substance is widely used in the field of chemical medicine.
In organic synthesis, it can be a key intermediate. Through delicate chemical reactions, it can be ingeniously combined with various reagents to derive new compounds with complex structures and unique functions. Chemists can use it to react with substances containing specific functional groups, according to nucleophilic substitution, addition and other reactions, to carefully construct complex organic molecular structures, paving the way for the creation of novel organic materials.
The path of pharmaceutical research and development is of great significance. Because of its unique chemical structure, it may have potential biological activity. Based on this, researchers can deeply explore its interaction with targets in vivo. After a series of experimental screening and optimization, it is expected to develop drugs with excellent efficacy, such as drugs for the treatment of specific diseases, and contribute to human health and well-being.
In the field of materials science, compounds that participate in the synthesis or give materials special properties. Such as improving the stability and optical properties of materials, play an important role in the research and development process of advanced materials, helping to explore new fields of material applications.

Today, there is a question about the market price of 4-thiazolecarboxylic acid, 2-bromo-5-methyl-methyl-methyl-ester. This compound belongs to fine chemicals in the field of organic chemistry. It is not easy to know its price, because many factors interact.
First, the cost of raw materials is the key. To prepare this methyl ester, raw materials such as 4-thiazolecarboxylic acid and 2-bromo-5-methyl-methyl-are required, and the price fluctuates. If raw materials are scarce, or the process of preparing raw materials is complicated and costly, the price of this methyl ester will be affected by it, and the tide will rise.
Second, the difficulty of the synthesis process also affects its price. If the synthesis of this methyl ester requires complicated steps, strict requirements on reaction conditions such as temperature, pressure, catalyst, etc., and the yield is not high, more manpower and material resources need to be invested in optimizing the process and improving the yield. In this way, the cost will increase greatly, and the market price will also rise.
Third, the market supply and demand situation is an important factor. If the market has strong demand for this methyl ester and the supply is limited, the merchants will raise the price when they see the opportunity to seek profits; conversely, if the supply exceeds the demand, the merchants may reduce the price in order to clear the inventory.
Fourth, the production scale also has an impact. In large-scale production, the unit production cost may be reduced due to the scale effect, and the price may be more affordable; in small-scale production, the cost is relatively high, and the price also rises.
In addition, factors such as regional differences, transportation costs, and market competition will make the market prices of 4-thiazolecarboxylic acid, 2-bromo-5-methyl-methyl-methyl ester different. Therefore, in order to know the exact market price, it is necessary to carefully observe the raw material market, process details, market supply and demand, etc., and always pay attention to the dynamics of the chemical product trading market in order to obtain a more accurate price.