4-(Pyridin-4-yl)-1,3-thiazole-2(3H)-thione

4- (Pyridine-4-yl) -1,3-thiazole-2 (3H) -thione is useful in various fields.
It has great potential for pharmaceutical research and development. The structure of Gainpyridine and thiazole endows it with unique chemical and biological activities. It can be used as a lead compound for medical scientists to explore in depth. After modification and optimization, it is expected to obtain new drugs with specific pharmacological activities. It may be able to target specific targets of certain diseases and exert therapeutic effects, such as in antibacterial, anti-inflammatory, anti-tumor, etc., all of which have research value and application potential. < Br >
also has its uses in the field of materials science. Due to its special molecular structure, it can participate in the construction of materials. It may improve some properties of materials, such as optical properties, electrical properties, etc. With this substance as the basic component, after specific processing, it may be possible to prepare materials with unique functions, which can be used in many materials such as optoelectronic devices and sensors.
In the field of organic synthesis, it is an important intermediate. Due to its structural characteristics, it can participate in a variety of organic reactions. Chemists use various reaction pathways as starting materials to construct more complex organic molecular structures. Through the selection of different reaction conditions and reagents, precise regulation of molecular structures can be achieved, and new approaches and methods for organic synthesis chemistry can be developed.
This 4- (pyridine-4-yl) -1,3-thiazole-2 (3H) -thione has important uses in medicine, materials, organic synthesis and other fields, providing new opportunities and possibilities for the development of various fields.

4- (pyridine-4-yl) -1,3-thiazole-2 (3H) -thione is also an organic compound. Its chemical properties are unique and worthy of in-depth study.
In terms of its physical properties, under room temperature, or as a solid state, it has a specific melting point and boiling point. Because its structure contains sulfur and nitrogen heterocycles, the intermolecular forces are unusual, and the melting point and boiling point are affected. Appearance may be a specific color state, but the exact color state depends on the purity and crystalline form.
In terms of chemical properties, the compound contains thiazole ring and pyridine group, both of which are reactive. In the thiazole ring, the sulfur atom has lone pair electrons, which are nucleophilic and can participate in nucleophilic substitution reactions. When encountering electrophilic reagents, the electron cloud distribution of the thiazole ring makes its specific position vulnerable to electrophilic attack and electrophilic substitution reactions occur. The electronegativity of the pyridyl group and the nitrogen atom causes the electron cloud density on the ring to be uneven, which also allows the pyridine ring to participate in various chemical reactions, such as complexing with metal ions to form stable complexes.
In addition, this compound contains thione groups, which have tautomerism and can be converted between thione and enethiol. This tautomerism balance is influenced by factors such as solvent, temperature and pH. The reactivity and physical properties of different isomers are different, which is of great significance in the field of organic synthesis and medicinal chemistry. In organic synthesis, it can be used as a key intermediate to construct complex organic molecular structures through various reactions. In drug development, or due to unique chemical structures and properties, it exhibits biological activities, such as antibacterial, anti-inflammatory and other pharmacological activities, and has great potential medicinal value.

The synthesis method of 4- (pyridine-4-yl) -1,3-thiazole-2 (3H) -thione has been known for a long time, and after many inquiries, various methods are now available below.
First, the raw material containing pyridyl group and the precursor containing thiazole ring are obtained by condensation reaction. This requires adding raw materials in a specific reaction vessel in precise proportions, and reacting at a suitable temperature and duration. For example, pyridine-4-formaldehyde and 2-amino-3-mercaptothiazole are stirred under moderate heating with alcohol as solvent and base as catalyst. The two are condensed, and the chemical bonds are rearranged and combined to obtain the final product. In this process, the polarity of the solvent, the type and dosage of the base are all related to the reaction rate and product purity.
Second, it is prepared by pyridination from the parent of thiazole-2-thione. First, thiazole-2-thione is taken, dissolved in a specific organic solvent, and then a pyridination reagent, such as pyridine-4-halide, is added. Under catalytic conditions, the halogen atom is substituted with a specific position on the thiazole ring to form 4- (pyridine-4-yl) -1,3-thiazole-2 (3H) -thione. In this reaction, the activity of the catalyst and the control of the reaction temperature are all key.
Third, the coupling reaction catalyzed by transition metals. Select suitable transition metal catalysts, such as palladium, copper and other complexes, use pyridyl halide and thiazole-2-thione derivatives as raw materials, and react in an inert gas protective atmosphere in the presence of ligands. Metal catalysts activate the check point of halogen atoms and thiazole rings to promote the coupling of the two. Among them, the type of metal catalysts and the structure of ligands have a great impact on the selectivity and efficiency of the reaction.
Although there are many methods for synthesizing this compound, the advantages and disadvantages of each method coexist. Either the raw materials are rare, or the reaction conditions are harsh, or there are many side reactions. To obtain products with high purity and high yield, it is necessary to fine-tune the reaction conditions and optimize the synthesis path according to the actual situation.

4- (pyridine-4-yl) -1,3-thiazole-2 (3H) -thione is useful in many fields.
In the field of pharmaceutical research and development, its structure is unique, containing the groups of pyridine and thiazolidone, or has specific biological activities. Pyridine rings are often present in many drug molecules, which can regulate the physicochemical properties of drugs, such as solubility and stability; thiazolidone structures also have potential pharmacological activities, or can interact with specific targets in organisms, such as enzymes or receptors, so in the creation of new drugs, or as a key structural unit, it helps to develop antibacterial, anti-inflammatory, anti-tumor and other drugs. < Br >
In the field of materials science, it can be used as a building block for functional materials. Due to the characteristics of atoms and chemical bonds in molecules, it may endow materials with unique electrical and optical properties. For example, it is used to prepare organic semiconductor materials, or to affect the charge transport properties of materials. It has shown its presence in the fields of organic electronic devices, such as organic Light Emitting Diodes, field effect transistors, etc.
In the field of agriculture, it may have agricultural activities such as insecticidal and bactericidal. By combining with key biomolecules in pests and pathogens, it interferes with their normal physiological activities, realizes the purpose of preventing and controlling pests, and provides a new direction for the research and development of green pesticides. In addition, in the field of chemical synthesis, it can be used as an important intermediate to introduce other functional groups through various chemical reactions, expand the structural diversity of compounds, and help to synthesize organic compounds with complex structures and specific properties, promoting the development of organic synthesis chemistry.

4- (Pyridine-4-yl) -1,3-thiazole-2 (3H) -thione is one of the organic compounds. Its physical properties are quite important, and it is related to its performance in various chemical processes and practical applications.
The morphology of this compound is mostly solid at room temperature and pressure, and its texture is fine. It may be in a crystalline state. Whether the crystal form is regular or not depends on its formation conditions. In terms of color, it is often between white and light yellow. Whether the color is pure or not is also affected by impurities in the preparation process.
The melting point is also a key physical property. Its melting point is about [specific value] ℃. When the temperature rises to this point, the substance gradually melts from the solid state to the liquid state. This phase change process requires a specific heat supply, and the exact value of the melting point can be used as an important indicator to identify the purity of the compound. If impurities are mixed in, the melting point may drop, and the melting range becomes wider.
In terms of solubility, 4- (pyridine-4-yl) -1,3-thiazole-2 (3H) -thione behaves differently in organic solvents. In common organic solvents such as ethanol and dichloromethane, it has a certain solubility and can form a homogeneous solution. This property is conducive to its participation in various organic reactions and provides a suitable environment for the reaction. However, in water, its solubility is very small, because its molecular structure is dominated by hydrophobic groups, and the interaction between water molecules is weak, so it is difficult to dissolve.
In addition, the density of this substance also has its specific value, about [specific value] g/cm ³, this value reflects the mass of its unit volume, which is of great significance in material measurement, phase separation and other operations.
And its volatility is very low. At room temperature, it rarely evaporates to the gas phase. This property makes it highly stable during storage and use, and it is not easy to be lost due to volatilization or cause environmental problems.