4-Methyl-5-thiazolecarboxylic acid

4-Methyl-5-thiazolecarboxylic acid is 4-methyl-5-thiazolecarboxylic acid, and its chemical structure is as follows.
Thiazolecarboxylic acid is a five-membered heterocyclic compound containing one sulfur atom and one nitrogen atom, which has aromatic properties. In this compound, the thiazolecarboxylic acid is the core structure. A methyl group ($- CH_3 $) is connected to the thiazolecarboxylic acid at position 4 of the thiazolecarboxylic ring. This methyl group is composed of one carbon atom and three hydrogen atoms, and is connected to the thiazolecarboxylic acid in the form of a single bond. At position 5 of the thiazolecarboxylic ring, a carboxyl group ($-CO Among them, the carbon atom is connected to the thiazole ring by a single bond, and the carbon atom is also connected to a double-bonded oxygen atom and a hydroxyl group ($-OH $). In this way, the unique chemical structure of 4-methyl-5-thiazolecarboxylic acid is formed. This structure endows the compound with specific physical and chemical properties and has important applications in many fields such as organic synthesis and medicinal chemistry.

4-Methyl-5-thiazolecarboxylic acid, that is, 4-methyl-5-thiazolecarboxylic acid, is widely used.
In the field of medicine, it is a key intermediate for drug synthesis. Many antibacterial and antiviral drugs are often prepared from this as the starting material. Through specific chemical reactions, its structure can be modified and integrated into the drug molecule, giving the drug unique biological activity and pharmacological properties. For example, when developing new antibacterial agents, 4-methyl-5-thiazolecarboxylic acid can be converted into compounds with high antibacterial effect through a series of reactions, which can inhibit or kill bacteria by interfering with the synthesis or metabolism of bacterial cell walls.
In the field of pesticides, it also plays an important role. It can be used to synthesize pesticides, fungicides and other pesticide products. Pesticides synthesized on its basis have good control effects on a variety of crop pests and pathogens. For example, some fungicides containing 4-methyl-5-thiazolecarboxylic acid structure can effectively resist plant fungal diseases, ensure the healthy growth of crops, and improve crop yield and quality.
In the field of organic synthetic chemistry, 4-methyl-5-thiazolecarboxylic acid is an important building block for organic synthesis. Due to its unique chemical properties of thiazole rings and carboxyl groups, it can participate in many organic reactions, such as esterification reactions, amidation reactions, etc. Through these reactions, complex and diverse organic compounds can be constructed, providing a rich material foundation for the development of organic synthetic chemistry and enabling scientists to create more organic materials with unique properties and functions.

4-Methyl-5-thiazolecarboxylic acid, this is an organic compound. Its physical properties are quite important and are relevant to many fields of application.
Looking at its appearance, it is usually a white to light yellow crystalline powder. This color characteristic is a key characteristic when it is initially identified. Under the solid state, the powder is delicate and the touch is also unique. However, this touch is not the primary consideration in practical research and application.
The melting point has a profound impact on its identification and application. After determination, the melting point of 4-methyl-5-thiazolecarboxylic acid is in a specific range, and this value accurately reflects the temperature node of its transition from solid to liquid. Knowing the melting point can help determine the purity. If the melting point of the sample deviates too much from the standard value, it may suggest that the purity is insufficient.
Solubility is also an important physical property. In common organic solvents, its dissolution performance varies. In some polar organic solvents, there is a certain solubility, while in non-polar solvents, the solubility is very small. For example, in polar solvents such as methanol and ethanol, it can dissolve to form a uniform solution. This characteristic is crucial in the chemical synthesis process. It can make the reactants fully contact and promote the reaction.
In addition, the density of 4-methyl-5-thiazolecarboxylic acid is also one of its physical properties. Although the density may not be as important as melting point and solubility in general experimental operations, in specific industrial production and engineering application scenarios, density data is related to the conversion of material volume and quality, which affects the precise control of production processes.
In summary, the physical properties of 4-methyl-5-thiazolecarboxylic acids, such as appearance, melting point, solubility, density, etc., have their own uses. They are all indispensable factors for chemical research, industrial production, etc., laying the foundation for their rational application.

The synthesis method of 4-methyl-5-thiazolecarboxylic acid has been around for a long time, and it has become more and more diverse with the changes of time.
In the past, the commonly used method was to start with compounds containing sulfur and nitrogen. First, take appropriate thiols, and halogenated hydrocarbons containing nitrogen, under the catalysis of bases, carry out nucleophilic substitution reaction. This process requires temperature control, time control, and is very particular about the ratio of reactants. The amount and type of base also affect the process and yield of the reaction. If the amount of base is too small, the reaction is delayed; if the amount of base is too large, side reactions will occur.
Thereafter, the obtained intermediate is treated with a specific oxidizing agent. The choice of oxidizing agent is related to the purity and yield of the product. Common oxidizing agents, such as potassium permanganate, potassium dichromate, etc., although they have strong oxidizing properties, their selectivity is poor, and they are prone to excessive oxidation and formation of many by-products. There are also mild oxidizing agents, such as hydrogen peroxide, that carry out oxidation reactions in the presence of appropriate catalysts, which can improve the selectivity of the reaction.
There are also steps based on thiazole rings, methylation and carboxylation to obtain the target product. During methylation, methylating reagents such as iodomethane and dimethyl sulfate are commonly used. In this step, the regulation of reaction conditions is crucial. If the temperature is too high, the methylation check point increases, and the product is complex; if the temperature is too low, the reaction is difficult to proceed. The carboxylation process, or the reaction of carbon dioxide with metal-organic reagents, or the reaction of halogenated hydrocarbons with sodium cyanide and then hydrolysis, has its own advantages and disadvantages.
In recent years, with the progress of science and technology, green synthesis methods have gradually emerged. For example, the enzyme-catalyzed method has mild reaction conditions and environmental friendliness, but the cost of enzymes is higher and the stability is poor. Microwave radiation, ultrasound-assisted and other technologies can also be used to speed up the reaction rate, increase the yield, and reduce the occurrence of side reactions. These new methods open up new avenues for the synthesis of 4-methyl-5-thiazole carboxylic acids.

I don't know what the price range of 4 - Methyl - 5 - thiazolecarboxylic acid is in the market. However, if you want to know the price of this product, you can explore it in many ways according to the method of "Tiangong Kaiwu".
First, you can visit the merchants in various cities. Where chemical raw materials are sold in the city, there may be this product. Ask all the stores and ask their prices. Different stores may have different prices due to supply, quality and quantity.
Second, you can ask for it on the Internet. Nowadays, e-commerce is prosperous, and there are many trading platforms for chemical products. Search for this product on it, and you can see the prices marked by various suppliers. However, you need to check their reputation and qualifications to prevent any untruths.
Furthermore, you can ask people in the industry. In the chemical industry, experts may know the approximate price range, or have bought and sold this product, and their words may have a reference value.
Although I cannot determine the price range, following this method, we may be able to obtain an approximate market price.