4 Methyl 1 3 Thiazole
quinoline thiophene imidazole thiazole

4-Methyl-1,3-thiazole

    Specifications

    HS Code

    634024

    Chemical Formula C4H5NS
    Molecular Weight 99.154 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 165 - 166 °C
    Density 1.15 g/cm³ (at 20 °C)
    Odor Characteristic, pungent odor
    Solubility In Water Slightly soluble
    Solubility In Organic Solvents Soluble in many organic solvents
    Flash Point 59 °C
    Stability Stable under normal conditions

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    General Information
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    Frequently Asked Questions

    As a leading 4-Methyl-1,3-thiazole supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4-Methyl-1,3-thiazole?
    4-Methyl-1,3-thiazole is also an organic compound. It has a wide range of uses and is used in various fields.
    First, in the field of medicine, this compound is often a key intermediate in drug synthesis. Due to its unique chemical structure, it can participate in the construction of many drug molecules, help the development of new drugs, and make great contributions to disease prevention and control. For example, in the preparation of some antibacterial and anti-inflammatory drugs, 4-methyl-1,3-thiazole plays an important role, which can be integrated into drug molecules through chemical reactions to give drugs specific pharmacological activity.
    Second, in the field of pesticides, it is also indispensable. It can be used to synthesize high-efficiency pesticides and help control crop diseases and pests. With its chemical properties, pesticide products that are highly targeted to pests and relatively friendly to the environment can be developed to escort agricultural harvests.
    Third, in the field of materials science, 4-methyl-1,3-thiazole also plays a role. Or it can be used to synthesize materials with special properties, such as some polymer materials with good stability and functionality. By reacting with other substances, the structure and properties of materials can be changed to meet different industrial needs.
    Fourth, in the field of organic synthesis chemistry, it is an important basic raw material. Chemists can carry out various organic synthesis reactions according to their structural properties, expand the variety and structure of organic compounds, and provide a variety of options for chemical research and industrial production. In conclusion, 4-methyl-1,3-thiazole, with its unique chemical structure, plays a key role in many fields such as medicine, pesticides, materials, and organic synthesis, and promotes the development and progress of related industries.
    What are the physical properties of 4-Methyl-1,3-thiazole?
    4-Methyl-1,3-thiazole is one of the organic compounds. It has unique physical properties, let me come one by one.
    Looking at its appearance, at room temperature, 4-methyl-1,3-thiazole is mostly colorless to light yellow liquid, clear and transparent, like morning dew, pure and free. Its taste is specific and irritating, and it smells like being in a special chemical atmosphere, but this smell is also one of its markers.
    When it comes to boiling point, it is between 145 ° C and 147 ° C, just like water boiling at 100 ° C. This temperature characteristic is a key parameter in separation, purification and application. The value of the boiling point determines its physical state transformation under a specific temperature environment, which is related to its experimental operation and industrial production process.
    In terms of melting point, it is usually about -38 ° C. At low temperatures, this compound is like a sleeping ice crystal, stable and quiet. The definition of melting point helps to understand its low temperature stability and phase transition conditions, and provides an important basis for storage and transportation.
    Solubility is also an important physical property. 4-methyl-1,3-thiazole is slightly soluble in water, like oil floating on the water surface, and the two are difficult to blend. This is due to the characteristics of the molecular structure. However, in organic solvents such as ethanol and ether, it can dissolve well, like a fish in water, and can dissolve with organic solvents to form a uniform solution system. This difference in solubility is of great significance in the process of chemical synthesis, extraction, etc., and can be used to separate and purify compounds according to this characteristic.
    The density is about 1.13 g/cm ³, which is slightly heavier than water. When it drops into water, it will slowly sink, like a stone entering water. This density characteristic is an important consideration in operations such as mixing and stratification of substances.
    In summary, the physical properties of 4-methyl-1,3-thiazole, such as color, odor, boiling point, melting point, solubility, and density, are interrelated and together constitute their unique physical properties, which are indispensable in the research, production, and application of chemistry.
    What are the chemical properties of 4-Methyl-1,3-thiazole?
    4-Methyl-1,3-thiazole, an organic compound with interesting chemical properties. This substance contains a thiazole ring with methyl substitution at the 4th position on the ring.
    From its structural view, the thiazole ring endows it with certain stability and unique reactivity. Due to the presence of nitrogen and sulfur atoms, it has a certain alkalinity. The electron cloud distribution on the thiazole ring is special, making the electrophilic substitution reaction prone to occur at a specific location.
    In the electrophilic substitution reaction, due to the electronic effect of nitrogen and sulfur atoms, the reaction check point is mostly at the 2nd and 5th positions of the thiazole ring. For example, during halogenation, halogen atoms tend to be connected at these positions. In addition, due to the electron donor effect of methyl group, it will affect the electron cloud density of thiazole ring, which in turn affects the reactivity and selectivity.
    In some organic synthesis scenarios, 4-methyl-1,3-thiazole can be used as a key intermediate. Due to its unique structure, it can participate in a variety of reactions to construct more complex organic molecules. And its chemical stability makes it stable under some reaction conditions, which is convenient for subsequent reaction operations.
    In common organic solvents, 4-methyl-1,3-thiazole has a certain solubility, which provides convenience for its participation in reactions in solution. Under suitable reaction conditions and catalysts, it can exhibit a variety of chemical activities, providing many possibilities for research and application in the field of organic synthetic chemistry.
    What are the synthesis methods of 4-Methyl-1,3-thiazole?
    The synthesis method of 4-methyl-1,3-thiazole covers many ways. Ancient Fangjia, often with specific raw materials, made by ingenious methods.
    First, it can be formed by condensation reaction of sulfur-containing compounds and nitrogen-containing compounds. For example, under appropriate reaction conditions, a sulfur-containing organic halide and a nitrogen-containing heterocyclic precursor can be combined. A suitable solvent, either alcohol or ether, should be selected so that the two can be fully mixed and reacted. And with the help of a specific catalyst, this catalyst can be either a metal salt or an organic base, which can promote the reaction, speed up the rate, and enable the reaction to be achieved under milder conditions. Under suitable temperature control, either at room temperature or heated to a certain degree, the reaction proceeds gradually, and finally 4-methyl-1,3-thiazole is obtained.
    Second, it can also be synthesized by rearrangement or ring-opening reaction of cyclic compounds. Take a specific cyclic precursor, which contains sulfur and nitrogen atoms and has appropriate substituents. Through the action of specific reagents, the ring is rearranged or opened, and the target 4-methyl-1,3-thiazole structure is formed. In this process, the choice of reagents is crucial, and different reagents can lead to different reaction paths and products. And the pH of the reaction environment, temperature and other factors have a significant impact on the process and results of the reaction. Fine regulation is required to make the reaction proceed in the expected direction and obtain a higher yield product.
    Or there may be other more complex multi-step reaction synthesis methods. First, the preliminary structural unit is constructed from the basic raw material, and then modified and connected many times to gradually achieve the complete structure of 4-methyl-1,3-thiazole. This multi-step reaction requires precise control of each step, from the purity of the raw material, the setting of the reaction conditions, to the separation and purification of the product. Only in this way can 4-methyl-1,3-thiazole be successfully synthesized.
    What are the precautions for using 4-Methyl-1,3-thiazole?
    4-Methyl-1,3-thiazole is an organic compound. During use, many key matters must be paid attention to.
    First, safety protection should not be underestimated. This compound may be toxic and irritating. When operating, appropriate protective equipment must be worn, such as gloves, goggles and gas masks. Because it may cause irritation to the skin, eyes and respiratory tract, after contact, it may cause redness, swelling, pain, cough and other uncomfortable symptoms. In case of inadvertent contact, rinse with plenty of water immediately and seek medical attention according to specific conditions.
    Second, storage conditions should not be ignored. Store in a cool, dry and well-ventilated place, away from fire and heat sources. Because of its flammability, in case of open flame, hot topic or cause combustion and explosion, the storage environment must be kept away from all kinds of ignition sources, and should be stored separately from oxidants, acids, etc., and must not be mixed with storage to prevent dangerous chemical reactions.
    Third, the use of the link needs to be precise operation. When conducting related experiments or industrial applications, it is necessary to strictly follow the established operating procedures and process requirements. Precise control of reaction conditions, such as temperature, pressure, reaction time, etc., is essential to ensure the smooth progress of the reaction and the quality of the product. A little carelessness, or the reaction may go out of control, causing a safety accident.
    Fourth, the disposal of waste shall be in accordance with regulations. Residues and waste after use should not be discarded at will, and should be properly disposed of in accordance with relevant environmental protection regulations. Because of its composition or pollution to the environment, special methods need to be used for harmless treatment to reduce the negative impact on the environment.
    In short, when using 4-methyl-1,3-thiazole, all aspects of safety, storage, operation and disposal should be given high priority, and must not be careless, so as to ensure the safety of personnel and environmental safety, while ensuring the scientific and orderly use process.