4-Ethoxycarbonylthiazole

The main use of 4-acetoxybenzamide is particularly important. This substance is often used in the field of pharmaceutical preparation to demonstrate its effectiveness. In the synthesis of pharmaceuticals, it can be used as a key intermediate to help create a variety of drugs with specific curative effects.
The unique chemical structure of 4-acetoxybenzamide can be ingeniously combined with many bioactive molecules to achieve the purpose of regulating physiological functions and healing diseases. For example, when developing anti-inflammatory drugs, it can be used as a basic framework to derive a series of new compounds with stronger anti-inflammatory activity and low side effects through chemical modification and derivatization.
Furthermore, in the field of materials science, 4-acetoxybenzamide also has its uses. In the preparation of special polymer materials, it can be introduced into the main chain or side chain of the polymer to change the physical and chemical properties of the material, such as improving the thermal stability and mechanical properties of the material, or endowing the material with special functions, such as the adsorption and optical properties of specific substances.
In the field of fine chemicals, 4-acetoxybenzamide can be used to synthesize high-end fragrance and cosmetic additives. It is popular because it can give products a unique smell or excellent skin care, moisturizing and other effects. Through accurate synthesis process and formula design, it can be delicately integrated into various fine chemical products to meet consumers' diverse needs for quality and functionality.

4-Acetoxybenzaldehyde is an important intermediate in organic synthesis. There are many methods for its synthesis. The following are detailed for you:
First, p-methylphenol is used as the starting material. Shilling p-methylphenol and acetic anhydride are acetylated under the action of an appropriate catalyst to obtain p-methylphenylacetate. This step is like building the cornerstone of a house and lays the foundation for subsequent reactions. Then, the p-methylphenylacetate is oxidized with an oxidizing agent such as potassium permanganate. After this oxidation process, the methyl group is converted into an aldehyde group, and 4-acetoxybenzaldehyde is successfully prepared. The steps of this path are relatively clear, and each step has its own key points. The acetylation reaction requires precise control of conditions to ensure the purity and yield of the product; the oxidation step also requires attention to factors such as reaction temperature and oxidant dosage. A slight error may affect the quality of the final product.
Second, p-hydroxybenzaldehyde is used as the starting material. The esterification reaction of p-hydroxybenzaldehyde and acetic anhydride occurs. Under suitable conditions, the hydroxyl group binds to the acetyl group in acetic anhydride to form 4-acetoxybenzaldehyde. This reaction process is like a clever chemical dance, and the reactants are bound in an orderly manner under specific circumstances. The advantage of this method is that the starting materials are relatively easy to obtain, and the esterification reaction conditions are relatively mild and easy to control. However, it is also necessary to pay attention to the side reactions that may occur during the reaction process, such as the hydrolysis of acetic anhydride, and corresponding measures need to be taken to avoid or control.
Third, 4-chlorobenzaldehyde can be started. First, 4-chlorobenzaldehyde undergoes a substitution reaction with sodium acetate, and the chlorine atom is replaced by an acetoxy group, thereby generating 4-acetoxy benzaldehyde. This reaction is like a replacement part, precisely replacing the chlorine atom with the desired acetoxy group. This method requires attention to the activity and selectivity of the substitution reaction. Different reaction conditions may lead to different product distributions, so the optimization of the reaction conditions is extremely critical. Factors such as reaction solvent, temperature, reaction time, etc. need to be carefully considered to achieve the best reaction effect.

4-Acetoxybenzaldehyde, its physical properties are as follows:
This substance is mostly white to light yellow crystalline powder at room temperature. Looking at its color, the pure color is white, and the occasional impurities are slightly yellow. The smell of its smell seems to have an elegant fragrance, but it is not a rich pungent taste, but a unique fragrance. Under the fine smell, you may feel a bit of freshness.
When it comes to the melting point, it is about 108-112 ° C. In this temperature range, the solid 4-acetoxybenzaldehyde slowly melts into a liquid state. This characteristic is an important basis for identification and separation in many chemical experiments and industrial production.
As for solubility, it exhibits different behaviors in organic solvents. In common organic solvents such as ethanol and ether, it has good solubility and can be fused with them to form a uniform solution. However, in water, its solubility is poor, and most of them are suspended or floating on the water surface with tiny particles, making it difficult to mix evenly with water. Due to the characteristics of molecular structure, its lipophilic and hydrophobic properties are determined.
In addition, the density of 4-acetoxybenzaldehyde is also an important aspect of its physical properties. Its density is moderate, although the exact value varies slightly due to measurement conditions, it is roughly within a specific range. When it comes to mixing, separation, etc., the consideration of density is indispensable, which is related to the distribution and interaction of substances in the system.
These physical properties are of great significance in many fields such as chemical synthesis and pharmaceutical research and development. With its melting point, solubility and other characteristics, the purification and identification of the substance can be realized, and the reaction process and product purity can be precisely controlled in different reaction systems.

4-Acetoxybenzaldehyde, its chemical properties are as follows:
This substance has an aldehyde group and an ester group. The aldehyde group is reductive and can be oxidized. In case of a weak oxidant Torun reagent, it can be oxidized to a carboxyl group to generate 4-acetoxybenzoate ammonium, and silver is precipitated at the same time. This is the silver mirror reaction. The reaction formula is: $C_ {9} H_ {8} O_ {3} + 2Ag (NH_ {3}) _ {2 OH}\ stackrel {\ triangle }{=\!=\!=} C_ {9} H_ {7} O_ {4} NH_ {4} + 2Ag\ downarrow + 3NH_ {3} + H_ {2} O $. In case of strong oxidizing agents such as acidic potassium permanganate solution, the aldehyde group can also be oxidized to a carboxyl group.
Its aldehyde group can also undergo an addition reaction, adding with hydrocyanic acid, the cyano group will be added to the carbon atom of the aldehyde group, and the hydrogen will be added to the oxygen atom to form a derivative of 2-hydroxy-2-phenylacetonitrile. This reaction can grow the carbon chain.
In terms of ester group properties, under acidic conditions, a hydrolysis reaction will occur to generate 4-hydroxybenzaldehyde and acetic acid. The reaction is: $C_ {9} H_ {8} O_ {3} + H_ {2} O\ stackrel {H ^{+}}{\ rightleft harpoons} C_ {7} H_ {6} O_ {2} + C_ {2} H_ {4} O_ {2} $, this is a reversible reaction. Under alkaline conditions, hydrolysis is more thorough, resulting in 4-hydroxybenzoate and acetate. Taking sodium hydroxide solution as an example, the reaction formula is: $C_ {9} H_ {8} O_ {3} + 2NaOH\ stackrel {} {\ longrightarrow} C_ {7} H_ {5} O_ {2} Na + C_ {2} H_ {3} O_ {2} Na + H_ {2} O $.
In addition, the benzene ring has a certain activity due to the influence of aldehyde and ester groups, and a substitution reaction can occur. If it is substituted with bromine under suitable catalysts and conditions, the bromine atom will enter the adjacent and para-position of the aldehyde group or ester group on the benzene ring to form the corresponding bromide.

The price of 4-acetoxybenzaldehyde in the market varies for many reasons. Its price often fluctuates due to factors such as the scarcity of raw materials, the simplicity of preparation, and the amount of market demand.
Generally speaking, in the market of ordinary chemical raw materials, the price of 4-acetoxybenzaldehyde with good quality may be in the range of several hundred yuan per kilogram. If the supply of raw materials is abundant, the preparation process is skilled and mature, and the market demand is relatively stable, the price may tend to the lower limit, or about two or three hundred yuan per kilogram.
However, if the raw materials are scarce, the preparation process is difficult, or the market demand suddenly surges, the price will rise. In some special scenarios, such as specific medicines and key raw materials for fine chemical synthesis, the price per kilogram can reach four or five hundred yuan, or even higher.
In addition, the price of 4-acetoxybenzaldehyde in different merchants and different purity grades is also different. For high purity, the price is often higher than that of ordinary purity due to the high cost of purification. To know the exact price, consult the chemical raw material suppliers in detail and compare their quotations to get the current price range.