4-Ethoxycarbonyl-5-methylthiazole

4-Isopropoxy-5-methylpyridine has a wide range of uses. In the field of pharmaceutical synthesis, it is often used as a key intermediate. Due to the special structure of this group, it endows the compound with specific chemical activity and spatial configuration, which can help chemists accurately construct complex drug molecular structures. Many innovative drugs for the treatment of cardiovascular diseases and nervous system diseases rely on its participation in the synthesis process to achieve the desired pharmacological activity and pharmacokinetic properties.
In the field of pesticide research and development, 4-isopropoxy-5-methylpyridine also plays an important role. On this basis, a series of highly efficient, low-toxic and environmentally friendly pesticide varieties can be derived. Such pesticides are highly selective to target pests, can effectively inhibit the growth and reproduction of pests, and have little harm to non-target organisms. They meet the needs of current green agriculture development and contribute greatly to ensuring crop yield and quality.
Furthermore, in the field of materials science, they can participate in the creation of functional materials. Through rational molecular design and chemical reaction, introducing them into polymer materials or organic semiconductor materials can significantly improve the electrical and optical properties of materials, laying the foundation for the development of new electronic devices, optoelectronic devices, such as organic light emitting diodes (OLEDs), solar cells and other cutting-edge technologies to promote technological innovation and development in related industries.

4-Isopropoxy-5-methylpyrazole is an organic compound with unique physical properties, detailed as follows:
- ** Appearance and Properties **: Under normal conditions, 4-isopropoxy-5-methylpyrazole is mostly white to off-white crystalline powder with fine texture, which is easy to identify and distinguish. Its powder shape is conducive to full contact with other substances in many chemical reactions and accelerates the reaction process.
- ** Melting Point and Boiling Point **: The melting point is about [X] ° C, at this temperature the substance changes from solid to liquid. The melting point is specific, and the purity of the compound can be identified by melting point determination. The boiling point is around [X] ° C. The boiling point reflects the energy required for the conversion of a substance from a liquid to a gaseous state, which is of great significance for its separation and purification.
- ** Solubility **: The compound exhibits good solubility in organic solvents such as ethanol and dichloromethane, and can be miscible with these solvents in a certain proportion. This property facilitates its use as a reactant or intermediate in organic synthesis, because most organic reactions occur in solution systems. However, the solubility in water is relatively low, which is related to the large proportion of hydrophobic groups in the molecular structure. < Br > - ** Density and stability **: The density is about [X] g/cm ³. Density, as the basic physical property of a substance, is very important in experiments and industrial production processes involving mass and volume conversion. 4-Isopropoxy-5-methylpyrazole has certain chemical stability under conventional conditions, but when it encounters strong oxidizing agents, strong acids or strong bases, chemical reactions may occur, resulting in structural changes. Therefore, when storing and using, it is necessary to avoid contact with such substances.
- ** Odor and Volatility **: Usually has a weak special odor, and a weak odor indicates relatively weak volatility. However, although the volatility is not strong, it should still be operated in a well-ventilated environment to prevent potential harm to the human body due to long-term exposure.

The chemical properties of 4-ethylhydroxy-5-methylpyrazole are particularly important and are related to many fields of chemical applications.
In this compound, the part of the ethyl hydroxyl group, the hydroxyl group has active chemical activity. The hydrogen atom of the hydroxyl group can participate in the formation of hydrogen bonds, which makes the substance exhibit unique solubility in polar solvents. And the hydroxyl group is easily oxidized, and when exposed to strong oxidants, it can be converted into other functional groups such as carbonyl groups, causing great changes in molecular chemical properties. At the same time, the presence of ethyl group increases the hydrophobicity of its molecules and affects its distribution behavior in different media. < Br >
The 5-methylpyrazole part, the pyrazole ring has a certain aromaticity, which endows the compound with special stability. The methyl group is attached to the pyrazole ring, and because the methyl group is the power supply group, the electron cloud density of the pyrazole ring can be changed, which affects the activity and check point selectivity of the electrophilic substitution reaction. Usually, the electron supply of the methyl group makes the electron cloud density of the pyrazole ring adjacent and para-position relatively high, and the electrophilic reagents are more likely to attack this check point.
In terms of acidity and basicity, the nitrogen atom on the pyrazole ring has a certain alkalinity, which can undergo protonation reaction with the acid to generate the corresponding salt. However, its basicity is weaker than that of typical aliphatic amines. Due to the aromaticity of the pyrazole ring, the lone pair electrons on the nitrogen atom participate in the conjugated system, reducing its ability to bind to the proton.
This 4-ethylhydroxy-5-methylpyrazole, due to the mutual influence of various parts of the structure, has rich and diverse chemical properties. It may have important uses in organic synthesis, pharmaceutical chemistry and other fields. It can be used as an intermediate to participate in the construction of complex compounds, and its special chemical properties can achieve specific reaction transformations.

4-Ethylhydroxy-5-methylpyridine, this is a class of organic compounds, and its synthesis methods are diverse. The following are common methods:
** First, through the substitution reaction of pyridine derivatives **
Take a suitable pyridine precursor and make it with a reagent containing ethyl and methyl under suitable reaction conditions. For example, using pyridine as the starting material, with the help of halogenated alkanes (such as bromoethane and iodomethane), in the presence of bases (such as potassium carbonate), in organic solvents (such as N, N-dimethylformamide), following the nucleophilic substitution reaction mechanism, ethyl of bromoethane and methyl of iodomethane can respectively replace hydrogen atoms at specific positions on the pyridine ring, then introduce ethyl and methyl groups, and at appropriate positions on the pyridine ring through specific oxidation or hydroxylation means to introduce hydroxyl groups. The key to this path is to precisely control the reaction conditions so that the substitution check point meets the structural requirements of the target product.
** Second, using a heterocyclic synthesis strategy **
Using small molecule compounds containing nitrogen and oxygen as raw materials, pyridine rings are constructed by cyclization reaction, and ethyl, methyl and hydroxyl are introduced at the same time. For example, ethyl acetoacetate, ammonia and acetaldehyde are used as starting materials to form pyridine rings through multi-step reactions. First, ethyl acetoacetate and ammonia undergo a condensation reaction, and then react with acetaldehyde to form the prototype of pyridine rings. After that, ethyl, methyl and hydroxyl are introduced at specific positions through a series of substitution and oxidation reactions. This strategy requires detailed control of the order and conditions of each step of the reaction to achieve accurate synthesis of the target product.
** III. Transition metal-catalyzed coupling reactions **
Transition metal catalysts, such as palladium, copper, etc., can be used to catalyze the coupling reaction between halogenates or borates containing pyridine structures and halogenates or borates containing ethyl groups and methyl groups. For example, using pyridine halide with ethyl borate and methyl borate as raw materials, under the action of palladium catalyst (such as tetra (triphenylphosphine) palladium) and base (such as sodium carbonate), react in a suitable solvent (such as toluene) to form a carbon-carbon bond, and then introduce ethyl and methyl groups, and then introduce hydroxyl groups through hydroxylation reactions. The advantage of this method is that the reaction selectivity is good, and the target product can be synthesized efficiently, but the selection of catalysts and the optimization of reaction conditions are quite demanding.

In today's market, the price of 4-isopropoxy-5-methylpyridine varies according to the quality, the amount of supply, and the urgency of demand.
Where the quality is high and pure, the price will be high; if the quality is low and the quality is mixed, the price will be slightly lower. And the wide and narrow production is also related to the price. If the production area is wide, the output is abundant, and the supply exceeds the demand, the price may decline; if the production area is narrow, the production is thin, and the demand exceeds the supply, the price may rise.
And the place of trade is different, and the price is also different. In bustling cities and important trade centers, the transportation is convenient, the flow of goods is smooth, and the price may be stable; in remote areas, the transportation is difficult, the cost is large, and the price may be slightly higher.
According to recent market conditions, the price of this product per catty is about [X] gold to [X] gold. However, the market situation changes, such as the situation is impermanent, so you can't be limited to one thing. Merchants should judge the situation and observe the changes in the market in order to seek their own profits.
The range of prices quoted above is only for temporary reference and cannot be relied on for a long time. To know the real-time price, you need to consult the people of Jia and the owners of the brokers in the cities before you can get a definite number.