4 Chloromethyl Thiazole
quinoline thiophene imidazole thiazole

4-Chloromethyl-thiazole

Taiy Chemical

Specifications

HS Code

817345

Chemical Formula C4H4ClNS
Molecular Weight 133.599 g/mol
Solubility In Water Low solubility (organic compound with polar - non - polar balance)
Solubility In Organic Solvents Soluble in many organic solvents like dichloromethane, ethyl acetate
Odor Pungent, characteristic sulfur - containing compound odor
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General Information
Frequently Asked Questions
What are the main uses of 4-chloromethyl-thiazole?
The main uses of 4-cyanoethyl-imidazoline are as follows:
This is an important organic compound with significant uses in many fields. In the field of chemical synthesis, it is often used as a key intermediate. Due to its unique structure, it can be converted into a variety of high-value compounds through a series of chemical reactions. For example, in the preparation of some functional polymers, 4-cyanoethyl-imidazoline can participate in the polymerization reaction, giving the polymer special properties such as better heat resistance and chemical corrosion resistance.
In the field of materials science, its use is also quite extensive. In the preparation of high-performance composites, 4-cyanoethyl-imidazoline can be used as a modifier. Adding to the matrix material can effectively improve the interfacial compatibility of the material, thereby enhancing the overall mechanical properties of the composite material. For example, in resin-based composites, it can enhance the bonding force between fibers and resins, so that when the material is subjected to external forces, the stress can be transmitted more evenly, avoiding the premature failure of the material due to local stress concentration.
Furthermore, in the field of biomedicine, it also shows potential application value. Because of its certain biological activity, some studies are dedicated to exploring its possibilities in drug synthesis. Or it can be used as a molecular structure fragment of drugs to participate in the construction of drugs with specific pharmacological activities, such as the development of new therapeutic drugs for certain diseases, providing new opportunities for the development of human health.
In the field of electronics industry, 4-cyanoethyl-imidazoline can be used to prepare electronic packaging materials. Electronic packaging materials need to have good electrical insulation, thermal stability and mechanical properties. 4-cyanoethyl-imidazoline participates in the synthesis of packaging materials, which can meet these performance requirements, protect electronic components from external environmental influences, and ensure the stable and reliable operation of electronic equipment.
In short, 4-cyanoethyl-imidazoline plays an important role in the chemical industry, materials, biomedicine, electronics and other fields with its unique chemical structure and properties. It is of great significance to promote technological progress and industrial development in various fields.
What are the synthesis methods of 4-chloromethyl-thiazole?
There are several common methods for the synthesis of 4-cyano-benzyl-pyridine:
One is the nucleophilic substitution reaction of halobenzyl and cyanopyridine. This is the use of the halogen atom of halobenzyl with higher activity, and the nitrogen atom of cyanopyridine is rich in electrons. Both can undergo nucleophilic substitution under appropriate base and solvent conditions. For example, using potassium carbonate as a base, in N, N-dimethylformamide (DMF) solvent, heating and stirring, the halogen atom of halobenzyl is replaced by the nitrogen atom of cyanopyridine, so as to obtain the target product. The raw materials of this method are relatively easy to obtain, and the reaction conditions are relatively mild. However, it is necessary to pay attention to the selectivity of halogenated benzyl, and there may be side reactions in the reaction, resulting in impurities such as double-substituted products. The reaction conditions and the proportion of reactants need to be carefully controlled.
The second is to use benzylnitrile and pyridine derivatives as starting materials through condensation reaction. Under the action of suitable catalysts, the cyano group of benzylnitrile and pyridine derivatives condensate. For example, transition metal catalysts, such as palladium and copper complexes, are used to catalyze the reaction of the two under basic conditions. Such methods can effectively construct carbon-nitrogen bonds and have good atomic economy. However, the cost of the catalyst is higher, the reaction requires a stricter system, and an anhydrous and oxygen-free environment is required, and the recovery and repurpose of the catalyst are also factors to be considered.
The third is the reaction of pyridine nitrogen oxide with halobenzyl, followed by reduction and cyanylation steps. First, pyridine forms nitrogen oxides to enhance its nucleophilicity, reacts with halobenzyl to form intermediates, and then reduces to remove oxygen atoms, and finally introduces cyanyl groups. This approach has a little more steps, but the selectivity of each step is better, and the structure of the product can be precisely regulated. However, the overall yield may be limited due to the multi-step reaction, and the separation and purification operation after each step is also cumbersome, requiring fine operation to ensure the purity and yield of the product.
What are the physical and chemical properties of 4-chloromethyl-thiazole?
4-Cyanomethyl-imidazole is an organic compound with unique physical and chemical properties.
Looking at its physical properties, under room temperature and pressure, 4-cyanomethyl-imidazole is usually in a solid state, white crystalline, delicate and regular. This substance exhibits good solubility in organic solvents, such as common methanol, ethanol, acetone, etc., which can be fused with it to form a uniform solution, just like a fish swimming in water, free from harm. However, the solubility in water is relatively limited, like the incompatible oil and water, which can only be slightly mixed.
When it comes to chemical properties, the activity of 4-cyanomethyl-imidazole is quite high. The cyanyl group can participate in many chemical reactions, such as hydrolysis reaction. Under certain conditions, the cyanyl group reacts quickly in contact with water like dry firewood and turns into a carboxyl group. It can also undergo an addition reaction, and it is closely bound to a variety of nucleophiles like magnetic poles that attract each other. And the imidazole ring is not an "idle person", it is weakly alkaline, just like a mild lye, which can neutralize with acids to form corresponding salts. Due to its unique chemical properties, 4-cyanomethyl-imidazole is widely used in the field of organic synthesis, acting as a master key that can open the door to the synthesis of many organic compounds and help chemists create complex new compounds, adding a strong touch to the world of chemistry.
What are the precautions for 4-chloromethyl-thiazole during storage and transportation?
4-Cyanomethyl-imidazoline is suitable for several ends during storage and transportation.
First, this material has certain chemical activity. When storing, be sure to choose a cool, dry and well-ventilated place. If it is exposed to high temperature or humidity, it may cause chemical reactions, damage quality, or even risk safety. If it is hot in the summer, it should be protected from direct sunlight, and the warehouse temperature should be controlled within a moderate range to avoid the risk of decomposition due to heat.
Second, during transportation, ensure that the packaging is intact. Due to its chemical properties, if the packaging is damaged or leaks, it will not only pollute the environment, but also pose a threat to the safety of transporters. Therefore, the packaging material should be solid and well sealed. For example, it should be filled in a special chemical packaging barrel, and a clear warning label should be marked on the barrel body to make it known to everyone that it is a special chemical.
Third, 4-cyanomethyl-imidazoline or is incompatible with other substances. When storing and transporting, do not mix with oxidants, acids, bases and other substances that may react. Otherwise, it may cause severe chemical reactions, such as combustion and explosion.
Fourth, relevant operators must be professionally trained and familiar with the characteristics, hazards and countermeasures of 4-cyanomethyl-imidazoline. In the process of storage and transportation, in case of emergencies, such as leakage, etc., it can be handled quickly and properly according to the established emergency plan to reduce the hazard.
In short, during the storage and transportation of 4-cyanomethyl-imidazoline, it is necessary to be cautious and follow the relevant safety regulations and operating guidelines to ensure its safety.
What is the market prospect of 4-chloromethyl-thiazole?
Today, the world is prosperous, people's livelihood is bustling, all industries are prosperous, and new products are emerging in the market, among which 4-cyano-pyridine is also among them. Looking at the market situation of 4-cyano-pyridine, the prospect is quite promising.
In today's world, science and technology are advancing, and various industries such as medicine and chemical industry are booming. 4-cyano-pyridine is used in the field of medicine and is a key raw material for the synthesis of many specific drugs. At present, there are various diseases, and the world's demand for medicine is increasingly important. The research of new drugs cannot be delayed. With its unique chemical properties, 4-cyano-pyridine is effective in drug synthesis, which can help medical craftsmen to produce drugs with curative effects on difficult and complicated diseases. Therefore, the prosperity of the pharmaceutical industry will increase the demand for 4-cyano-pyridine.
In the chemical industry, 4-cyano-pyridine is also an important intermediate. With the increasing application of chemical products in daily use, industry and other fields, the scale of chemical production continues to expand. 4-cyano-pyridine is an indispensable link in the synthesis chain of many chemical products, and its market demand is also increasing with the rise of the chemical industry.
Furthermore, the current global trade exchanges are frequent and smooth. The production and sales of 4-cyano-pyridine are not limited to a corner, and it also has a place in the international market. Overseas countries, either due to resource limitations or technical needs, are quite interested in 4-cyano-pyridine. It is the prosperity of international trade that adds to the market situation of 4-cyano-pyridine.
However, the market situation is changing rapidly. Although 4-cyano-pyridine has a bright future, there are still some worries. For example, within the industry, the competition in the same industry may become fierce. If everyone sees the benefits and flocks to chase them, it may lead to overcapacity and prices falling. And technological innovation is advancing rapidly, and new products may replace 4-cyano-pyridine in the position of medicine and chemical industry in the future.
But overall, with the current situation, 4-cyano-pyridine has broad prospects in the market. If the industry can judge the situation, grasp the technology, and respond to market changes, it will be able to take the lead in the business sea and enjoy the dividends brought by the prosperity of this market.