4 Chloromethyl 2 Isopropylthiazole Hydrochloride
quinoline thiophene imidazole thiazole

4-(chloromethyl)-2-isopropylthiazole hydrochloride

Taiy Chemical

Specifications

HS Code

161844

Chemical Name 4-(chloromethyl)-2-isopropylthiazole hydrochloride
Molecular Formula C7H11Cl2NS
Molecular Weight 212.14
Appearance Solid (Typically, exact appearance can vary)
Solubility Solubility characteristics would depend on the solvent, e.g., may have some solubility in polar organic solvents
Melting Point Specific melting point data would require experimental determination
Boiling Point Boiling point data would need to be experimentally obtained
Pka Data on pKa would be determined by appropriate acid - base titration experiments
Logp LogP value, related to lipophilicity, would need experimental or computational determination
Stability Stability can be affected by factors like temperature, light, and humidity
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General Information
Frequently Asked Questions
What are the chemical properties of 4- (chloromethyl) -2-isopropylthiazole hydrochloride
4- (chloromethyl) -2 -isopropyl thiazole hydrochloride is an organic compound. It has unique chemical properties.
From the structural point of view, the thiazole ring is its core structure, and the thiazole ring contains sulfur and nitrogen heteroatoms, which endows the compound with specific electronic properties and chemical activities. The 2-position isopropyl is an alkyl substituent, which increases its lipid solubility and affects its solubility in different solvents and intermolecular forces. In the chloromethyl chloride at the 4 position, the chlorine atom has strong electronegativity, which makes the carbon-chlorine bond polarity quite large. This structural feature makes the compound electrophilic and prone to substitution reactions with nucleophiles, such as reacting with alcohols and amines nucleophiles to generate corresponding substitution products. This property can be used to construct new carbon-heteroatom bonds in organic synthesis to expand the structural diversity of the compound.
Its hydrochloride form greatly increases the solubility of the compound in water. Because hydrochloride can be ionized in water, it forms an ionic state and binds to water molecules through ion-dipole interaction, which is conducive to reactions or applications in aqueous systems. Under acidic conditions, the compound has good stability, and may react with strong bases, thiazole rings or chloromethyl groups. Under heating or the presence of specific catalysts, it can initiate intramolecular rearrangement or condensation reactions with other compounds, showing rich reactivity and potential applications in pharmaceutical chemistry, materials science and other fields.
What are the main uses of 4- (chloromethyl) -2-isopropylthiazole hydrochloride
4- (chloromethyl) -2 -isopropylthiazole hydrochloride is one of the organic compounds. It has a wide range of uses and is often a key intermediate in the synthesis of many drugs in the field of medicinal chemistry. Taking the creation of antibacterial drugs as an example, their structural properties can enable them to participate in a series of chemical reactions, be modified and constructed, and converted into molecules with antibacterial activity, or by combining with specific bacterial targets, inhibit the growth and reproduction of bacteria, and achieve the purpose of treating infectious diseases.
In the field of materials science, 4- (chloromethyl) -2 -isopropylthiazole hydrochloride also has extraordinary performance. It can be used as a starting material for the synthesis of special functional materials, such as the preparation of materials with specific adsorption properties. Due to the active groups such as chloromethyl in the molecular structure, other functional functional groups can be introduced through chemical reactions to endow the material with adsorption selectivity for specific substances, and play an important role in the process of separation and purification.
In addition, in the field of organic synthetic chemistry, as a reaction substrate, it can participate in a variety of organic reactions, such as nucleophilic substitution reactions. Chloromethyl has high activity and is easy to react with various nucleophilic reagents to generate organic compounds with more complex structures. It provides an important basic raw material for organic synthetic chemists to construct novel organic molecular structures and contributes to the development and innovation of organic synthetic chemistry.
What is the synthesis method of 4- (chloromethyl) -2-isopropylthiazole hydrochloride
The synthesis method of 4- (chloromethyl) -2 -isopropylthiazole hydrochloride is detailed as follows.
Start with suitable starting materials, such as sulfur-containing compounds and related reagents with halogenated methyl and isopropyl groups. The sulfur-containing reagent and the halogenated methyl reagent are often reacted under specific reaction conditions, such as in a suitable solvent, with a base as a catalyst, and the temperature and reaction time are controlled to promote the nucleophilic substitution reaction to generate a sulfur-containing and halogenated methyl intermediate.
Then, the intermediate and the isopropylation reagent are reacted in a similar or adjusted reaction environment. This step also requires precise regulation of solvent, catalyst and temperature conditions, so that the isopropyl group can successfully connect to the specific position of the thiazole ring to form the 4- (chloromethyl) -2 -isopropylthiazole parent structure.
Finally, the obtained 4- (chloromethyl) -2 -isopropylthiazole is mixed with hydrogen chloride gas or hydrochloric acid solution in a certain proportion, and at the appropriate temperature and reaction time, a salt-forming reaction occurs, and finally 4- (chloromethyl) -2 -isopropylthiazole hydrochloride is obtained.
The entire synthesis process requires fine control of the reaction conditions at each step, from the proportion of raw materials, solvent selection, catalyst dosage to temperature and time regulation, all of which are crucial. A slight error may affect the purity and yield of the product.
What are the storage conditions for 4- (chloromethyl) -2-isopropylthiazole hydrochloride?
4- (chloromethyl) -2 -isopropylthiazole hydrochloride is a kind of chemical substance. Its storage conditions are crucial and related to the stability and quality of the substance.
This substance should be stored in a cool and dry place. A cool environment can protect the substance from high temperature. High temperature often causes the molecular movement of the chemical substance to intensify, triggering chemical reactions and causing it to deteriorate. Therefore, in a cool place, it can slow down the movement of molecules and maintain the stability of its chemical structure.
A dry environment is also indispensable. Moisture in the air may react with the substance, such as hydrolysis. Hydrolysis reactions may change its chemical properties and damage its efficacy. Therefore, keep it dry to avoid contact with water and prevent chemical reactions.
Furthermore, the storage place should be well ventilated. Good ventilation can disperse volatile gases that may accumulate. If volatile gases accumulate in a confined space, or reach a certain concentration, in case of open flames and other factors, there is a risk of explosion and other hazards. Good ventilation can reduce this risk.
And it should be placed away from fire and heat sources. Fire and heat sources can easily cause the temperature of the substance to rise sharply, causing dangerous reactions.
In addition, when storing, it needs to be stored separately from oxidants, acids, bases, etc. Due to its chemical properties, contact with the above substances, or severe chemical reactions, can lead to dangerous consequences.
In short, 4 - (chloromethyl) -2 - isopropylthiazole hydrochloride should be stored in a cool, dry, well-ventilated place away from fire and heat sources, and separate from specific chemicals to ensure its quality and safety.
What is the price range of 4- (chloromethyl) -2-isopropylthiazole hydrochloride in the market?
I have not obtained the exact price range of "4 - (chloromethyl) -2 - isopropylthiazole hydrochloride" in the market. However, the price of this product can be explored by many parties.
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