4,5-DIHYDRO-2-(6-HYDROXY-2-BENZOTHIAZOLYL)-4-THIAZOLECARBOXYLIC ACID POTASSIUM SALT

This is a compound of 4,5-dihydro-2- (6-hydroxy-2-benzothiazolyl) -4-thiazole carboxylic acid, potassium salt. To clarify its chemical structure, consider its name. "4,5-dihydro" shows the hydrogenation of the 4th and 5th carbon interbonds of the thiazole ring. "2 - (6-hydroxy-2-benzothiazolyl) " Epibenzothiazole ring has a hydroxyl group at the 6th position, and this benzothiazole group is connected to the 2nd position of the thiazole ring. "4-thiazole carboxylic acid" Epithiazole ring has a carboxyl group at the 4th position. " "Potassium salt" refers to the carboxyl group forming a salt with potassium ions.
Its structure can be depicted as follows: draw the benzothiazole ring first, and add the hydroxyl group at the 6th position. Then connect the thiazole ring to the second position of the benzothiazole ring. At the 4th position of the thiazole ring, the carboxyl group is attached to the potassium ion.
In summary, the structure of this compound contains benzothiazole and thiazole two rings, with hydroxyl and carboxyl groups, and the carboxyl group is in the state of potassium salt.

4% 2C5-dihydro-2- (6-hydroxy-2-benzothiazolyl) -4-thiazole carboxylic acid, potassium salt, this substance has important uses in many fields.
In the field of medicine, it may have unique medicinal potential. The benzothiazolyl and thiazole carboxylic acid structures in its chemical structure may interact with specific targets in organisms. Like some compounds containing thiazole structures, it can affect the activity of specific enzymes to regulate physiological processes. Perhaps the potassium salt can act on disease-related enzymes, such as inflammation-related enzymes, to exert anti-inflammatory effects; or it can act on specific targets in tumor cells, providing new ideas for the development of anti-tumor drugs.
In the field of materials science, it may be used to prepare special functional materials. Because it contains multiple heterocyclic structures, these structures give molecules unique electronic properties and spatial configurations. For example, it may be used as an organic ligand to complex with metal ions to form complex materials with special optical and electrical properties. Such materials may exhibit excellent properties in photoelectric displays, sensors, etc., such as the manufacture of sensor materials with high sensitivity to specific substances.
In agriculture, there may also be application value. Due to its structural characteristics, it may have inhibitory effects on certain crop diseases and insect pests. For example, some compounds containing thiazole rings have good inhibitory activity against plant pathogens. This potassium salt may be developed into a new type of pesticide, and compared with traditional pesticides, it may have higher selectivity and lower toxicity due to its unique structure, which is more friendly to the environment.
In the field of chemical research, it is an important intermediate in organic synthesis. Its complex structure can be modified and transformed through various chemical reactions, providing a basis for the synthesis of more organic compounds with novel structures and unique functions. Chemists can introduce different functional groups through the activity check point of its structure, expand the types and properties of organic compounds, and promote the development of organic synthetic chemistry.

To prepare 4% 2C5-dihydro-2- (6-hydroxy-2-benzothiazolyl) -4-thiazolecarboxylic acid and potassium salt, the method is as follows:
First, the required raw materials must be prepared, such as compounds containing 6-hydroxy-2-benzothiazolyl, precursors with thiazolecarboxylic acid structure and potassium sources.
In the reactor, a suitable organic solvent, such as ethanol, dichloromethane, etc. is used to create a reaction environment. The raw material containing 6-hydroxy-2-benzothiazolyl and the precursor of thiazole carboxylic acid are put into the kettle in an appropriate molar ratio. Generally speaking, the ratio of the two may be between 1:1.2 and 1:1.5, in order to fully react.
Then, slowly add alkalizing agents, such as potassium carbonate, potassium hydroxide, etc., to make the system alkaline and facilitate the reaction. The amount of alkali depends on the activity of the raw material and the scale of the reaction.
At a moderate temperature, or between 40 and 60 ° C, continue to stir to make the reaction system fully contact and react. During this process, pay close attention to the progress of the reaction, which can be monitored by means of thin layer chromatography (TLC).
When the reaction is asymptotically completed, that is, when the TLC shows that the raw material point almost disappears, the reaction is terminated.
After the reaction is completed, the reaction solution is poured into an appropriate amount of water, extracted with an organic solvent, and the organic phase is collected. Then the organic phase is dried with a desiccant such as anhydrous sodium sulfate to remove the moisture.
After that, the organic solvent is removed by distillation under reduced pressure to obtain a crude product.
The crude product is refined by column chromatography or recrystallization, and a suitable eluent or solvent, such as petroleum ether-ethyl acetate mixture or ethanol-water system, is selected to improve the purity of the product.
Pure 4% 2C5-dihydro-2- (6-hydroxy-2-benzothiazolyl) -4-thiazolecarboxylic acid, potassium salt can be obtained through these steps.

4,5-Dihydro-2- (6-hydroxy-2-benzothiazolyl) -4-thiazolecarboxylic acid, potassium salt, has many physical properties. Its properties may be solid, mostly powdery, fine and uniform, with a certain color, or white or yellowish, depending on the preparation process and purity.
When it comes to solubility, its performance in water is quite important. Usually at room temperature, it has a certain solubility in water, but it is not very soluble. When exposed to hot water, the dissolution rate may be accelerated, and the solubility will also increase. Organic solvents, such as ethanol, also have a certain tendency to dissolve, but the degree varies. For polar organic solvents, the dissolution is relatively better than that of non-polar ones.
Melting point is also a key physical property. It has a specific melting point. When heated to this temperature, the substance will gradually change from solid to liquid. This melting point can be used as an important indicator to identify the purity of the substance. If the purity is high, the melting point range is relatively narrow and close to the theoretical value; if it contains impurities, the melting point may decrease and the melting range becomes wider.
Furthermore, the density cannot be ignored. Although it is often not paid attention to by everyone, under specific chemical operations or research scenarios, the density is related to the calculation of the dosage and mixing ratio of the substance. Its density value is stable, providing a basis for precise operation in related processes. < Br >
The physical properties of this substance are of great significance in the fields of chemical engineering, pharmaceuticals, etc., and are related to its preparation, separation, and application.

4,5-Dihydro-2- (6-hydroxy-2-benzothiazolyl) -4-thiazole carboxylic acid, potassium salt, when using, many matters must be observed.
First, pay attention to its physicochemical properties. The morphology, color, odor and other characteristics of this compound need to be clarified. Knowing its solubility, how it dissolves in water and organic solvents, is related to its application. If the solubility of this substance is not observed, or when it is used, it cannot be properly dispersed and mixed, which affects its efficacy.
Second, safety is also of paramount importance. It is necessary to know in detail whether it is toxic and irritating. What is the impact on the human body after contact with the skin, eyes, or inhalation or ingestion. If not handled properly, it may cause damage to personnel's health. In the working environment, be sure to take protective measures, such as wearing suitable protective gloves, goggles, masks, etc., to prevent accidental contact.
Third, stability should not be ignored. Can this object remain stable under different environmental conditions, such as temperature, humidity, light, etc. High temperature, high humidity or strong light exposure, or cause it to decompose and deteriorate, thereby changing its chemical structure and properties. When storing, according to its characteristics, choose suitable conditions, such as dry, cool, dark place, to ensure its quality and performance.
Fourth, the method of use and dosage also need to be accurately grasped. Different application scenarios have different requirements for its use and dosage. Excessive use may cause waste of resources and other adverse consequences; insufficient dosage will make it difficult to achieve the desired effect. Be sure to determine the appropriate dosage and operation steps in strict accordance with relevant procedures or experimental results.
In summary, the use of 4,5-dihydro-2- (6-hydroxy-2-benzothiazolyl) -4-thiazole carboxylic acid and potassium salts should be treated with caution in terms of physical and chemical properties, safety, stability, and usage methods to ensure safe and effective use.