3-methoxy-benzo[d]isothiazole

3-Methoxy-benzo [d] isothiazole is widely used in the fields of medicine, pesticides and materials in this world.
In the field of medicine, it is often the key intermediate for the creation of new drugs. Because of its unique structure, it has a variety of biological activities, such as antibacterial, anti-inflammatory, anti-tumor and other effects. Medical experts use it as a basis and carefully research and refine it, hoping to develop new drugs with excellent efficacy and small side effects to help patients all over the world.
As for the field of pesticides, 3-methoxy-benzo [d] isothiazole also plays an important role. Due to its ability to inhibit and kill many pests and pathogens, it can be used to prepare high-efficiency, low-toxicity, and environmentally friendly pesticides to protect farmers from pests and diseases.
Furthermore, in the field of materials, it can participate in the synthesis of special materials. After ingenious combination, the material is endowed with unique properties, such as excellent stability, corrosion resistance, etc., and is widely used in electronics, chemical and other industries to help the equipment to be durable and of outstanding quality.
In summary, although 3-methoxy-benzo [d] isothiazole is a chemical substance, it has key uses in medicine, pesticides, materials, etc., and has made extraordinary achievements in promoting the development of various industries and improving people's livelihood.

3-Methoxy-benzo [d] isothiazole, this is an organic compound. Its physical properties are unique, let me talk about them one by one.
Looking at its appearance, under room temperature and pressure, it usually takes the shape of a solid state, or is powdery, or is crystalline, fine and uniform, with a white or nearly white color, just like the purity of frost and snow.
As for its melting point, it is about a specific temperature range. Due to the force between molecules, when heated to a certain extent, the lattice structure begins to be destroyed, and it gradually melts from a solid state to a liquid state. This melting point value is an important physical identification of the compound, and it is quite valuable in identification and purity determination.
The boiling point is also one of the key physical properties. In a specific pressure environment, the compound is heated to the boiling point, and the liquid phase is converted to the gas phase. This process requires a continuous supply of energy from the outside world to overcome the attractive force between molecules. The determination of boiling point can provide an important basis for the separation and purification of compounds.
In terms of solubility, 3-methoxy-benzo [d] isothiazole exhibits a certain solubility in organic solvents. For example, in some polar organic solvents, such as alcohols and ketones, it can be moderately dissolved. This is because some groups in the molecular structure can form specific interactions with organic solvent molecules, such as hydrogen bonds, van der Waals forces, etc. However, in water, its solubility is relatively limited, due to the poor matching of the overall polarity of the molecule and the polarity of the water molecule.
Density is also a factor to consider its physical properties. Its density reflects the mass per unit volume of the substance, and compared with other substances, it can help to judge its distribution in the mixed system. The density of this compound varies depending on the compactness of the molecular structure, the type and number of atoms, and has a fixed value under certain conditions.
In addition, the volatility of this compound is low. Due to its strong intermolecular force, the molecule is not easy to break away from the condensed phase and enter the gas phase. In normal environments, it rarely evaporates into the air. This characteristic also affects its stability and preservation in practical applications.
In summary, the physical properties of 3-methoxy-benzo [d] isothiazole, including appearance, melting point, boiling point, solubility, density and volatility, are interrelated and have their own characteristics, which lays an important foundation for its research and application in many fields such as chemistry and chemical industry.

The chemical properties of 3-methoxy-benzo [d] isothiazole are particularly important, which is related to its performance in various chemical processes and application fields.
As far as its stability is concerned, its structure is endowed with a certain stability due to the conjugation system of benzene ring and isothiazole ring. However, the presence of methoxy groups has an electron donor effect, or affects the electron cloud distribution of molecules, and then slightly changes the stability under specific conditions. When encountering strong oxidizing agents, the sulfur atoms in them may be oxidized, resulting in structural changes and impaired stability.
In terms of reactivity, the carbon atoms of the methoxy group o and para-position, due to the conjugation effect of the methoxy group to the electron, the electron cloud density is relatively high, and it is easy to form a check point for the attack of electrophilic reagents, triggering electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. The nitrogen and sulfur atoms on the isothiazole ring have lone pairs of electrons, which can complex with metal ions and participate in the reaction of coordination chemistry to form complexes with specific structures and properties.
In terms of solubility, because it contains the hydrophilic group methoxy, it may have a certain solubility in some polar organic solvents, such as ethanol and acetone; however, due to the presence of aromatic rings in the molecule, the whole has a certain hydrophobicity, and the solubility in water may be limited.
In addition, the chemical properties of 3-methoxy-benzo [d] isothiazole are also significantly affected by reaction conditions such as temperature, pH, solvent, etc. High temperature may accelerate the reaction process, and a specific pH environment may change the charge state of the molecule, thereby affecting its reactivity and selectivity.
In summary, the chemical properties of 3-methoxy-benzo [d] isothiazole are rich and complex, and are influenced by the interaction of various groups in the molecular structure and external conditions. It has potential application value and research significance in many fields such as organic synthesis, medicinal chemistry, and materials science.

The preparation method of 3-methoxy-benzo [d] isothiazole, although the ancient book "Tiangong Kaiwu" does not directly contain the preparation method of this specific compound, it can be deduced from the chemical process wisdom and common preparation ideas of the ancients.
In the past, the preparation of heterocyclic compounds was often based on the extraction and transformation of natural substances or the gradual construction of simple raw materials. For 3-methoxy-benzo [d] isothiazole, it can be started from the precursor containing benzene ring and sulfur-nitrogen heterocyclic ring.
First, o-methoxy benzoic acid is used as the starting material. First, it is converted to acid chloride, which can react with bifunctional reagents containing sulfur and nitrogen. If thioamide reagents are used, under the catalysis of appropriate bases, through nucleophilic substitution and cyclization steps, it is expected to construct benzoisothiazole ring systems. Among them, the choice of bases is quite critical. Common weak bases such as potassium carbonate and sodium carbonate, or strong bases such as sodium hydride, need to be carefully regulated according to the reactivity.
Second, start from o-methoxybenzaldehyde. First condensate with thiols to form thioacetals, and then react with nitrogen-containing reagents in the presence of oxidants. If with hydroxylamine derivatives, under mild oxidation conditions, they can be oximized and cyclized to form targets. The oxidation step can be carried out with a mild oxidizing agent such as hydrogen peroxide under the catalysis of a suitable catalyst such as a transition metal salt, so that the reaction can be accurately advanced in the target direction.
Furthermore, learn from ancient books for the synthesis of similar heterocycles, and pay attention to the mildness of reaction conditions and the simplicity of raw materials. The reaction solvent is more common solvents such as water and alcohol to fit the conditions at that time. At the same time, pay attention to the control of reaction time and temperature. For example, low temperature is conducive to controlling the selectivity of the reaction, and heating can speed up the reaction process. After many times of exploration and observation of the phenomenon, a suitable preparation method is finally obtained.

I don't know what the price range of "3-methoxy-benzo [d] isothiazole" is in the market. This is a more specialized and specific chemical, and its price is susceptible to many factors.
First, purity is the key factor. If the purity is extremely high, almost reaching the scientific research level, and can meet the needs of high-end experiments, the price must be high; if the purity is slightly lower, it is only suitable for general industrial use, and the price is relatively low.
Second, the market supply and demand relationship has a great impact. If the market has strong demand for this product, but the supply is limited, like water in a dry time, the price will rise; conversely, if the supply is sufficient and the demand is flat, like water flooding a ditch, the price will easily drop.
Third, the difficulty of preparation is also related to the price. If the preparation requires complex processes, special raw materials or harsh conditions, such as fine iron and good craftsmen for swords, the cost will be high, and the price will also increase; if the preparation is relatively simple, the cost will be reduced, and the price will be close to the people.
Fourth, the sales area and channel differences are different. In busy cities or specific chemical markets, prices may fluctuate due to different transportation, storage and operating costs; direct sales and resale through multi-layer dealers, prices will also be different.
However, I have searched for ancient books all over the world, but I have not obtained the exact price range. It is difficult to know what the current market price is.