3 Chlorobenzisothiazole
quinoline thiophene imidazole thiazole

3-Chlorobenzisothiazole

    Specifications

    HS Code

    579288

    Chemical Formula C7H4ClNS
    Molecular Weight 169.63
    Appearance Solid (usually white or off - white powder)
    Odor Characteristic odor
    Melting Point Around 127 - 130 °C
    Boiling Point Decomposes before boiling
    Solubility In Water Poorly soluble
    Solubility In Organic Solvents Soluble in some organic solvents like ethanol, acetone
    Density Approx. 1.48 g/cm³
    Stability Stable under normal conditions, but may react with strong oxidizing agents
    Purity Typically available in high purity grades (e.g., 98%+)

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    General Information
    Where to Buy 3-Chlorobenzisothiazole in China?
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    Frequently Asked Questions

    As a leading 3-Chlorobenzisothiazole supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 3-Chlorobenzisothiazole?
    3-Chlorobenzoisothiazole is also an organic compound. It has a wide range of uses and has important applications in many fields such as chemical industry, medicine, and materials.
    In the chemical industry, it is often a key intermediate in the synthesis of other fine chemicals. Due to its special molecular structure, it can participate in a variety of organic reactions, such as nucleophilic substitution, cyclization, etc. With exquisite synthesis strategies, many compounds with unique properties can be derived, providing a cornerstone for the innovation of chemical products.
    In the field of medicine, 3-chlorobenzoisothiazole shows potential medicinal value. Studies have found that its structure may interact with specific targets in organisms, or have pharmacological activities such as antibacterial, anti-inflammatory, and anti-tumor. Pharmaceutical researchers can conduct in-depth research based on this, and develop new drugs through structural modification and optimization to benefit human health and well-being.
    In the field of materials, it also plays an important role. Due to its unique chemical properties, it can be used to prepare materials with special properties. For example, it can be introduced into the structure of polymer materials, endowing materials with excellent properties such as weather resistance and corrosion resistance, improving the quality and application range of materials, and is widely used in the improvement of materials such as coatings and plastics. With its unique chemical structure and properties, 3-chlorobenzoisothiazoline plays an indispensable role in many fields such as chemical industry, medicine, materials, etc., injecting vitality into the development of various fields and promoting technological innovation and progress.
    What are the physical properties of 3-Chlorobenzisothiazole?
    3-Chlorobenzoisothiazole, also an organic compound. Its physical properties are quite important, and are described in detail today.
    Looking at its morphology, under room temperature, it is mostly white to light yellow crystalline powder, which is easy to identify and use. Its texture is delicate and special to the touch. However, caution should be taken when using it to prevent harm to the body.
    When it comes to melting point, it is about a specific range, and this value has a great impact on its identification and related processes. The stability of the melting point also indicates its excellent purity.
    As for solubility, it has a certain solubility in common organic solvents, such as ethanol and acetone. This property allows it to be dissolved in various chemical reactions and preparations, and it can be dissolved in a suitable solvent according to demand, so as to achieve the desired effect. However, in water, its solubility is very small, which is due to the difference between the molecular structure and the polarity of water.
    Its density is also a specific value. Although it is not easy to intuitively detect such as shape and melting point, in chemical production and related scientific research, accurately knowing its density is related to the measurement of materials and the accuracy of mixing proportions, which has a great impact.
    In addition, its volatile properties also need attention. Under normal environmental conditions, the volatilization rate is slow, but if it is exposed to high temperature or a specific environment, the volatilization will increase. At this time, proper protective measures should be taken to avoid its escape from the environment and endanger the human body and the environment.
    In summary, the physical properties of 3-chlorobenzisothiazole are diverse, and each property has its own uses in different fields. In the process of production and research, it needs to be carefully considered to achieve the best results and ensure safety.
    What are the chemical properties of 3-Chlorobenzisothiazole?
    3-Chlorobenzoisothiazole is also an organic compound. Its chemical properties are specific and worthy of in-depth investigation.
    This substance has certain stability, but under specific conditions, it can also exhibit active reactivity. In its molecular structure, the chlorine atom is connected to the benzoisothiazole ring, giving it a unique chemical behavior.
    When encountering nucleophiles, the chlorine atom is easily replaced. The edge chlorine atom has considerable electronegativity, making the C-Cl bond polar. Nucleophiles are prone to attack this carbon atom, causing the chlorine atom to leave and form new compounds. For example, under basic conditions with alcohols, a nucleophilic substitution reaction can occur, and chlorine is replaced by alkoxy groups to obtain corresponding ether derivatives.
    In the oxidizing environment, the benzoisothiazole ring may change. The sulfur atoms in the thiazole ring may have variable valence states or be oxidized to higher valence sulfur oxides. The rate and degree of this oxidation reaction are affected by reaction conditions, such as the type, concentration, and temperature of the oxidizing agent.
    When irradiated or heated, 3-chlorobenzoisothiazole may initiate intramolecular rearrangement. The chemical bonds between the benzo ring and the thiazole ring are rearranged due to energy excitation, resulting in isomers with different structures. This process involves the breaking and formation of chemical bonds, which is a complex chemical change.
    And because of its aromatic properties, it can participate in aromatic electrophilic substitution reactions. Under appropriate catalyst and reaction conditions, other functional groups can be introduced on the benzene ring to expand the possibility of its chemical derivation, which has great application potential in the field of organic synthesis. In short, 3-chlorobenzoisothiazole has rich chemical properties and is an important object for the research and application of organic chemistry.
    What are 3-Chlorobenzisothiazole synthesis methods?
    The synthesis method of 3-chlorobenzoisothiazole has been known since ancient times, and there are many ways. First, it starts with o-aminobenzonitrile, and through halogenation reaction, chlorine atoms are ingeniously introduced to obtain the target product. In this halogenation method, either chlorine gas or chlorine-containing reagents are used. The control of reaction conditions is crucial. Temperature, time, and reagent dosage can all affect the reaction process and yield.
    Furthermore, it is also a good strategy to perform chlorination reaction based on benzoisothiazole. This reaction requires the selection of suitable catalysts, such as metal salts, to promote the precise placement of chlorine atoms to generate 3-chlorobenzoisothiazole. The choice of catalyst and the choice of reaction medium need to be carefully considered in order to make the reaction efficient and highly selective.
    Another raw material containing sulfur, nitrogen and chlorine is formed by cyclization and condensation. This process is complicated, but careful adjustment of reaction conditions, such as pH and temperature changes, can also achieve the goal. The correct proportion of each raw material and the order of the reaction steps are all key. Although there are many methods of synthesis, each has its advantages and disadvantages, or the raw material is rare, or the reaction conditions are harsh, or the yield is not high. If you want to obtain 3-chlorobenzoisothiazole, you need to weigh the advantages and disadvantages according to the specific situation and choose the best method to get twice the result with half the effort and achieve satisfactory results.
    3-Chlorobenzisothiazole what are the precautions during use
    3-Chlorobenzoisothiazole is an important organic compound that is widely used in industry, scientific research and other fields. However, when using it, many precautions must not be forgotten.
    Bear the brunt, and safety protection must not be ignored. This compound has certain toxicity and irritation, or causes damage to the human body. When coming into contact, be sure to wear protective clothing, gloves, protective glasses and other equipment to avoid direct contact with the skin and eyes. If you come into contact accidentally, you should immediately rinse with plenty of water and seek medical attention in time. The place of use should also be well ventilated to prevent inhalation of its volatile gases. If inhaled, you should quickly go to a fresh air place, and if necessary, perform artificial respiration and seek medical attention.
    Secondly, storage conditions are also crucial. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources, and protected from direct sunlight. It needs to be stored separately from oxidants, acids, bases, etc., and should not be mixed with storage to avoid danger caused by chemical reactions.
    Furthermore, the operating specifications during use should not be underestimated. Strictly follow the experimental procedures or production process operation, and precisely control the reaction conditions, such as temperature, pressure, reaction time, etc. Use suitable reaction vessels and equipment, and ensure that they are clean and dry, so as not to affect the reaction results due to impurities. After the experiment is completed, the remaining 3-chlorobenzoisothiazole and reaction products should be properly disposed of in accordance with relevant regulations, and should not be discarded at will to prevent environmental pollution.
    In addition, it is necessary to have an in-depth understanding of its properties and potential hazards. Master its physical and chemical properties in order to better deal with possible problems during use. At the same time, know the reactions that may occur under different conditions, and take preventive measures in advance to ensure the safety of the use process.