3-Amino-5-nitro-2,1-benzisothiazole

3-Amino-5-nitro-2,1-benzisothiazole This substance has a wide range of uses. In the field of medicine, it can be a key intermediate for the synthesis of specific drugs. Due to its unique chemical structure, it can participate in the construction of a variety of drug molecules, or show unique effects on specific diseases, helping to develop new therapeutic agents.
In the field of materials science, it also has important functions. It can be used as a special additive to add to polymer materials to improve material properties. For example, it can enhance material stability and corrosion resistance, so that the material can still maintain good performance in complex environments, expanding material application scenarios.
In agriculture, it also has potential uses. Or it can be used to develop new pesticides. With its special chemical properties, it can inhibit or kill certain pests and pathogens, providing a new way for crop protection, and has a small impact on the environment, which is in line with the needs of green agriculture development.
Furthermore, in the field of scientific research, it is an important chemical reagent. Researchers can deeply explore its chemical reaction characteristics to understand the relevant chemical mechanism, provide support for new chemical synthesis methods and theoretical development, and promote the continuous progress of chemistry.

3-Amino-5-nitro-2,1-benzisothiazole, this material property is special, related to many fields of chemical and pharmaceutical industry. It is crystalline, light yellow to light brown in color, and stable under conventional temperature and pressure. The melting point is about 190-195 ° C. The morphological transformation at this temperature is of great significance for its separation and purification.
In terms of solubility, it is slightly soluble in water, because its molecular polarity is different from water, but it has good solubility in polar organic solvents such as dimethyl sulfoxide, N, N-dimethylformamide. This property needs to be considered when preparing solutions and constructing reaction systems.
3-Amino-5-nitro-2,1-benzoisothiazole is basic, and amino groups can form salts with acids. This property is used for compound separation and specific reaction catalysis. Its nitro activity is high, and it can be converted into amino groups by reduction reaction, and a variety of nitrogen-containing compounds can be derived, which is of great significance for the expansion of organic synthesis pathways.
In addition, it has certain biological activity or potential value in the field of pharmaceutical research and development, and can be used as a lead compound for the geophysical exploration of new drugs. However, safety also needs to be paid attention to when using, and appropriate protective measures are essential to avoid potential hazards.

The stability of the chemical properties of 3-amino-5-nitro-2,1-benzoisothiazole is related to many aspects.
Looking at its structure, the skeleton of benzoisothiazole has a certain stability. The substitution of amino and nitro groups has a great influence on its properties. The amino group has the property of electrons, while the nitro group is a strong electron-absorbing group. The two coexist on the benzene ring, and the distribution of electron clouds changes significantly.
In terms of reactivity, amino groups can increase the density of electron clouds in the ortho and para-position of the benzene ring, which is easy to initiate electrophilic substitution reactions; the presence of nitro groups, although reducing the overall electron cloud density of the benzene ring, makes it more prone to nucleophilic substitution reactions under specific conditions.
However, in terms of stability, 3-amino-5-nitro-2,1-benzisothiazole is still stable in normal environments without specific reagents or conditions. In case of extreme conditions such as strong acids, strong bases, or high temperatures and light, it may be difficult to maintain stability.
Strong acids or amino-induced protonation can change the molecular charge distribution and reactivity; under strong bases, nitro or amino groups can undergo related reactions and cause structural changes. High temperature and light can also provide energy to promote intramolecular rearrangement or decomposition reactions.
Therefore, in general, the stability of 3-amino-5-nitro-2,1-benzisothiazole is a relative concept and depends on the specific environment and conditions. It is relatively stable under normal conditions, but may change under special conditions.

The synthesis of 3-amino-5-nitro-2,1-benzoisothiazole is an important topic in the field of organic synthesis. Its synthesis paths are diverse, and different starting materials and reaction conditions can be selected to achieve it.
First, anthranilic acid is often used as the starting material. Anthranilic acid is first reacted by diazotization. This process requires proper treatment of sodium nitrite and an appropriate amount of acid in a low temperature environment to form a diazonium intermediate. This diazonium salt has high activity, and then reacts with thiocyanate to introduce thiocyanyl groups, and then cyclizes to form benzoisothiazole structures under suitable temperature and catalyst action. Subsequently, for the obtained benzoisothiazole derivatives, the nitro group is introduced by nitrification reaction with suitable nitrifying reagents such as a mixed acid system of concentrated nitric acid and concentrated sulfuric acid, which is precisely controlled in the appropriate temperature range. Finally, by means of reduction method, suitable reducing agents, such as iron powder and hydrochloric acid, are selected to reduce the nitro group to an amino group, and then the target product is 3-amino-5-nitro-2,1-benzoisothiazole.
Second, o-halobenzoic acid or its derivatives can also be used as the starting material. First, it is reacted with thiourea to generate the corresponding sulfur-containing intermediate, and then the benzoisothiazole skeleton is constructed by cyclization reaction. The subsequent steps are also as above, after nitrification and reduction reactions, nitro and amino groups are introduced in sequence to complete the synthesis of the product.
Furthermore, some synthesis routes will use a protective group strategy. Due to the susceptibility of certain groups during the reaction process, in order to ensure the selectivity and smooth progress of the reaction, a protective group is introduced at a specific stage, and then the protective group is removed after the desired reaction is completed. Although the steps of this synthesis may be slightly complicated, it can effectively improve the purity and yield of the product.
When synthesizing 3-amino-5-nitro-2,1-benzoisothiazole, precise control of reaction conditions is crucial. Factors such as temperature, reaction time, and reagent dosage will significantly affect the reaction process and product quality. During the synthesis process, modern analytical methods, such as thin-layer chromatography and nuclear magnetic resonance, are also required to monitor and characterize the reaction intermediates and products to ensure the high efficiency and accuracy of the synthesis path.

The price range of 3-amino-5-nitro-2,1-benzoisothiazole in the market is difficult to determine. This is due to the fickle market conditions, and the price of this product is affected by many factors.
First, the price of raw materials has a great impact on it. If the raw materials required for its synthesis are scarce or expensive, the price of the finished product will also rise. Second, the difficulty of the preparation process is closely related to the cost. If a complicated and expensive process is required, the price will be higher. Furthermore, the market supply and demand trend is also the key. If there are many people who want it, but the supply is small, the price will rise; conversely, if the supply exceeds the demand, the price may fall.
In addition, the price set by different manufacturers varies due to differences in cost control, brand effect, etc. To know the exact price range, it is advisable to consult chemical product suppliers, distributors, or refer to the quotations of chemical product trading platforms. However, these prices are only for current reference and cannot be determined for a long time. The market is constantly changing, and prices may rise and fall at any time.