2-Thiazolesulfonyl chloride (9CI)

2-Thiazole sulfonyl chloride (9CI), which has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate. The unique structure of the thiazole ring has good biological activity and drug affinity. With 2-thiazole sulfonyl chloride, sulfonyl chloride groups can be introduced. After various reactions, such as reacting with nucleophiles such as nitrogen and oxygen, compounds with specific pharmacological activities can be constructed, laying the foundation for the development of new drugs.
In the field of pesticide chemistry, it also plays an important role. It can participate in the synthesis of a variety of high-efficiency pesticides, and by virtue of its chemical properties, it endows pesticides with excellent characteristics such as better absorption and durability, which helps to improve the control effect of crop diseases and pests and ensure agricultural harvest.
In the field of organic synthetic chemistry, 2-thiazole sulfonyl chloride is an extremely valuable reagent. Sulfonyl chloride groups have high activity and can be used for esterification, amidation and many other reactions to construct complex organic compounds, expand organic synthesis paths, and promote the development of organic chemistry. In short, 2-thiazole sulfonyl chloride plays an indispensable role in many fields and has a profound impact on the progress of related industries.

2-Thiazolesulfonyl chloride (9CI) is an organic compound with specific physical properties. Its appearance is usually colorless to light yellow liquid or solid, depending on the purity and environment. If it is a liquid, it is liquid in mass and flowing, if it is a solid, it is a crystalline powder.
This substance has a pungent smell, pungent smell, and irritation to the nasal cavity, eyes, and respiratory mucosa. It is relatively stable at room temperature and pressure. In case of hot topics, open flames, or contact with strong oxidants, there is a risk of chemical reactions or even explosions.
Its melting point, boiling point, etc. are also important physical properties. The melting point is about [X] ° C, that is, when the temperature reaches this value, the substance changes from solid to liquid state. The boiling point is about [X] ° C, at this temperature, the substance changes from liquid to gaseous.
In terms of solubility, 2-thiazole sulfonyl chloride is insoluble in water because its molecular structure lacks groups that interact with water molecules to form hydrogen bonds. However, it is soluble in some organic solvents, such as dichloromethane, chloroform, ether, etc., and can be well dispersed and dissolved in these solvents. This property is often used in organic synthesis reactions to facilitate the reaction.
The density is about [X] g/cm ³, which is heavier than water. If it is accidentally spilled on water, it will sink to the bottom of the water.
The physical properties of this compound are of great significance in the fields of organic synthesis and drug development. Synthesizers choose suitable reaction conditions and separation and purification methods according to their melting point, solubility and other properties to achieve the purpose of efficient synthesis and product purification.

The chemical stability of 2-thiazole sulfonyl chloride (9CI) is related to many aspects. This compound has a specific molecular structure, and the thiazole ring is connected to the sulfonyl chloride group. The sulfonyl chloride group has high activity and is easy to participate in a variety of chemical reactions.
Looking at its chemical stability, the chlorine atoms in the sulfonyl chloride group have a tendency to leave, and it is easy to undergo nucleophilic substitution reactions when encountering nucleophiles, such as alcohols and amines. Alcohol interacts with it to form sulfonates; amine reacts with it to form sulfonamides. This all indicates that its chemical properties are active and its stability is not good. < Br >
And although the thiazole ring has certain aromatic properties, it can also participate in the reaction under specific conditions. When exposed to strong oxidizing agents, or oxidized, the ring structure changes.
During storage, due to its activity, it needs to be properly preserved. Avoid humid environment, because water can promote its hydrolysis, sulfonyl chloride hydrolyzes to form sulfonic acid and hydrogen chloride.
In summary, 2-thiazole sulfonyl chloride (9CI) has active chemical properties and poor stability. During operation and storage, it is necessary to be careful. Appropriate protection and preservation measures should be taken according to its characteristics to prevent unnecessary reactions.

The preparation of 2-thiazole sulfonyl chloride (9CI) requires specific steps. First, thiazole is taken as the starting material and placed in a clean reaction vessel. Then, an appropriate amount of chlorosulfonic acid is added, which is the key reagent. The dosage needs to be precisely controlled to ensure a smooth reaction. After mixing the two, slowly heat to maintain the temperature in a specific range, about 60 to 80 degrees Celsius. When heating, continue to stir to allow the reactants to fully contact and react evenly. During this process, pay close attention to the reaction phenomena, such as temperature changes, gas escape, etc. After a period of reaction, specific color changes or precipitation formation can be observed in the reaction system.
After the reaction is completed, cool the reaction mixture. After that, a suitable separation method is used, such as distillation or extraction. First, the preliminary product is separated by distillation according to the difference in the boiling point of each substance. Then the extraction operation is carried out, and a suitable organic solvent is selected to extract the target product from the reaction mixture. After extraction, the organic phase is dried to remove the remaining moisture. Finally, the product is further purified through the recrystallization step to obtain a pure 2-thiazolesulfonyl chloride (9CI). The whole preparation process requires strict control of each link condition to obtain satisfactory results.

I don't know what the price range of 2-thiazole sulfonyl chloride (9CI) is in the market. However, if you want to explore its price, you can go to the place where chemical raw materials are traded and ask the merchants specializing in chemical products. Or you can go to the online platform of chemical product trading and carefully check the prices quoted by different sellers to get the approximate price range.
The price of chemical products often varies due to the quality, the amount of purchase, the situation of supply and demand, the distance of origin and market fluctuations. If the quality is good, the price may be high; if you buy in large quantities, the seller may have a profit. When the market demand is strong and the supply is scarce, the price also tends to rise; the origin is far away, and the transportation fee increases, and the price is also affected. < Br >
Therefore, in order to know the exact price range of 2-thiazolyl chloride (9CI), it is necessary to search for information widely, compare with many parties, discuss with sellers in detail, and consider various factors to obtain a more accurate price.