2-tert-Butoxycarbonylamino-thiazole-5-carboxylic acid

2-tert-butoxycarbonyl amino-thiazole-5-carboxylic acid, this physical property is special, and it is related to the delicacy of chemistry. Its shape or powder state is often white or off-white, fine and uniform.
The point of melting and boiling is the key physical property. For the melting point, when it is at a specific temperature, it is self-solidifying and liquid. The temperature is mostly between hundreds of degrees of residue, but the exact value varies depending on the purity. For the boiling point, if you want to make it liquid and gas, the required temperature is quite high, or hundreds of degrees of residue, because of its intermolecular force.
Solubility is also a key feature. In organic solvents, such as dichloromethane, N, N-dimethylformamide, it often has good solubility and can be uniformly dispersed, just like water and emulsion blend. However, in water, the solubility is inferior, because of its molecular structure, hydrophobic groups dominate, making it weak to mate with water.
In terms of stability, in the conventional environment, under normal temperature and pressure, it is quite stable, and it can survive for a long time without changing its properties. In case of strong acid and alkali, the structure may change, and various reactions such as hydrolysis occur. You also need to be careful when exposed to heat. Under high temperature, it may cause decomposition and damage its inherent properties.
This compound has a wide range of uses in the field of organic synthesis. It is often a key intermediate that can participate in the construction of complex organic molecules, which can be used in the development of drugs, or as a cornerstone for opening up new paths, which is related to the great cause of human health.

The synthesis method of 2-tert-butoxycarbonyl amino-thiazole-5-carboxylic acid, although it is not contained in the classic "Tiangong Kaiwu", can refer to the method of its lattice and deduce it by chemical means.
First, it can be started from compounds containing thiazole rings. If a suitable halogenated thiazole is used as a raw material, the tert-butoxycarbonyl amino group is introduced through a nucleophilic substitution reaction. First, the halogenated thiazole is reacted with a tert-butoxycarbonyl amination reagent, such as tert-butoxycarbonyl azide, in the presence of a suitable base, such as potassium carbonate or sodium carbonate, in a suitable solvent, such as N, N-dimethylformamide (DMF). The reaction temperature may be controlled in a moderate range, such as 50-80 ° C. After several years, the amino group can be successfully introduced to form a thiazole intermediate containing tert-butoxycarbonyl amino group.
Second, the carboxyl group of this intermediate is constructed. The halogen atom can be introduced into the appropriate position of the thiazole ring first, and then the halogen atom can be replaced by a cyanyl group to form a cyanothiazole derivative. After hydrolysis, the cyanyl group is converted into a carboxyl group. For halogenation, a halogenating agent such as N-bromosuccinimide (NBS) can be selected, and the reaction is carried out in the presence of light or an initiator. The cyanide substitution step is to react with a cyanizing agent such as potassium cyanide or sodium cyanide in a suitable solvent such as acetone. Hydrolysis is catalyzed by an acid or base, such as hydrochloric acid or sodium hydroxide solution, heated and refluxed to promote the hydrolysis of cyanyl to carboxyl groups, resulting in 2-tert-butoxycarbonyl amino-thiazole-5-carboxylic acid.
During the synthesis, attention should be paid to the precise control of reaction conditions, the purity of solvents and reagents, and the separation and purification of intermediate products, in order to improve the yield and purity and achieve the purpose of synthesis.

2-tert-butoxycarbonyl amino-thiazole-5-carboxylic acid, which is used in many fields such as medicine and chemical synthesis.
In the field of medicine, it is a key intermediate for the synthesis of characteristic drugs. Due to the unique structure of the thiazole ring, it is endowed with a variety of biological activities. On this basis, drugs with antibacterial effects can be carefully constructed. When the bacterial cell wall is synthesized, the relevant drugs are precisely acted to effectively block the key links, thereby inhibiting the growth and reproduction of bacteria, and opening up new ideas for antibacterial treatment. In the journey of anti-tumor drug research and development, it has also emerged. After ingenious modification and modification, drugs can precisely target specific molecular targets of tumor cells, interfere with abnormal signal transduction pathways of tumor cells, induce apoptosis of tumor cells, and contribute to the solution of cancer problems.
In the field of chemical synthesis, it is an important cornerstone for the creation of functional materials. With its own special chemical structure, it can be cleverly polymerized with other compounds to generate unique polymer materials. Such materials may have excellent optical properties and play a role in the field of optical device manufacturing, such as used to make high-resolution optical lenses to improve imaging clarity; or have special electrical properties and shine in the manufacture of electronic components, such as used in the manufacture of high-performance conductive films to improve the conductivity of electronic devices.
With its unique structure and active reactivity, this compound has painted a colorful picture of applications in the fields of medicine and chemical synthesis, like a magic key, opening up new doors for innovation and development in many fields.

2-tert-butoxycarbonyl amino-thiazole-5-carboxylic acid, the price of this product in the market is difficult to be fixed. The change in its price depends on many reasons.
Looking at the price of chemical industry in the past, the supply and demand of raw materials is the main factor. If the raw materials required for its preparation are easy to harvest, abundant in production, and abundant in the market, the price may become stable and cheap. On the contrary, raw materials are rare and expensive, and the demand exceeds the supply, and their price will rise. For example, if a certain year of age, a specific chemical raw material production area suffers a disaster, and the production and demand are not reduced, the price of related products will immediately rise.
The method of preparation also affects its price. If the technology is new and simple, the consumption is small and the production is large, and the cost is reduced, the price can also be reduced. In the past, there were chemical methods, which were complicated and expensive. Later, new technologies were introduced, the steps were reduced and the efficiency increased, and the price of the product decreased accordingly.
The needs of the city are also the key. If in the fields of medicine, chemical industry, etc., the demand for this product is strong, and the price can often be firm or even increase. If a new drug is developed and this compound is needed as a material, the price will rise as a result of a large number of seekers.
Furthermore, changes in the current situation and the regulations of the government can affect its price. Trade policies, environmental protection regulations, or cost increases, the price is also affected by it. The merchants of ancient times were all familiar with the needs of the current situation and the order of the government, and today's chemical trade is no different.
Therefore, in order to know the market price of 2-tert-butoxycarbonyl amino-thiazole-5-carboxylic acid, we can obtain a more accurate price by carefully examining the factors of raw materials, production methods, demand and current politics.

In order to determine the purity of 2-tert-butoxycarbonyl amino-thiazole-5-carboxylic acid, various methods can be used. The first is high-performance liquid chromatography (HPLC), which is a commonly used and accurate method. The sample is injected into the HPLC system with a suitable mobile phase and a stationary phase. Due to the different interactions between each component and the stationary phase and the mobile phase, the migration rate in the column is different, resulting in separation. The purity of the target can be calculated by the external standard method or the internal standard method according to the peak area or peak height by a detector, such as an ultraviolet detector.
Gas chromatography (GC) can also be used, but the sample needs to be volatile or volatile after derivatization. Separated by a gas chromatography column and tested by a detector to determine the purity. However, if this compound is difficult to volatilize, the GC method may be limited.
In addition, the melting point determination method can help to judge. The melting point of pure substances is fixed. If it contains impurities, the melting point often drops and the melting range increases. The sample is placed in a melting point meter, and the melting temperature and melting range can be roughly judged. However, this is only an auxiliary. Due to multiple factors that can affect the melting point, it is difficult to accurately determine the purity.
Elemental analysis method can measure the proportion of each element in the sample, the ratio with the theoretical value, and can know the impurity situation and deduce the purity. However, it requires professional equipment and technology, and the operation is complicated and time-consuming. < Br >
Infrared spectroscopy (IR) can identify the functional groups of compounds. Compared with the standard spectrum, the presence or absence of impurity peaks is known, and the purity is determined. However, it is difficult to determine the purity by IR alone, and it is often used in combination with other methods.
In summary, in order to obtain accurate purity, high-performance liquid chromatography is preferred, supplemented by other methods, which can more accurately judge the purity of 2-tert-butoxycarbonyl amino-thiazole-5-carboxylic acid.