2-tert-Butoxycarbonylamino-thiazole-5-carboxylic acid ethyl ester

Ethyl 2-tert-butoxycarbonyl amino-thiazole-5-carboxylate is an organic compound. It has a wide range of uses and is often found in the field of organic synthesis.
In medicinal chemistry, it is often used as a key intermediate. Due to its unique chemical structure, many bioactive compounds can be derived through a series of chemical reactions. For example, when developing new antibacterial drugs, chemists will use this as a starting material, modify its structure, introduce different functional groups, and explore and synthesize new drug molecules that have inhibitory effects on specific bacteria.
In the field of materials science, it also has its uses. Part of the research is dedicated to applying the special structures constructed by these compounds to the preparation of new functional materials. For example, the synthesis of materials with special optical and electrical properties is expected to show unique advantages in optoelectronic devices, such as Light Emitting Diodes, sensors, etc.
Furthermore, in pesticide chemistry, it can be used as an important basic material for the synthesis of new pesticides. After structural modification and optimization, the synthesis of pesticide products with high efficiency in killing crop pests, environmental friendliness and low residue can ensure the smooth progress of agricultural production. In conclusion, 2-tert-butoxycarbonyl amino-thiazole-5-carboxylate ethyl ester plays an indispensable role in many chemical-related fields due to its structural characteristics, and contributes an important force to the development of various fields.

Ethyl 2-tert-butoxycarbonyl amino-thiazole-5-carboxylate is an important compound in the field of organic chemistry. Its physical properties are as follows:
Looking at its properties, it usually appears as a white to off-white solid. This property is more common in many organic synthesis reaction products. Due to the arrangement and interaction of atoms and groups in the molecular structure, it exists in the world as a condensed state at room temperature and pressure.
When it comes to the melting point, it is about a specific temperature range. This temperature range varies or changes slightly due to differences in the purity of the compound and test conditions, but the approximate range is relatively stable. This property is of great significance for the identification and purity judgment of the compound. Due to the different purity of the compound, its melting point may deviate from the standard range.
As for solubility, it shows good solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), etc. This is because the molecular structure of the compound contains groups that can interact with organic solvent molecules, such as tert-butoxycarbonyl, ester groups, etc., which can form forces such as van der Waals forces and hydrogen bonds with organic solvent molecules, so it is soluble. However, due to the poor solubility in water, due to the strong hydrophobic properties of the molecule as a whole, it is difficult for water molecules to form effective interactions with the compound molecules to overcome its intermolecular forces, making it difficult to dissolve in water.
In addition, the compound has certain stability. Under conventional storage conditions, in a dry and cool place, the molecular structure can be maintained relatively stable, and it is not easy to decompose or deteriorate. When encountering extreme conditions such as strong acids and bases, some functional groups in its structure, such as tert-butoxy carbonyl, ester groups, etc., may undergo chemical reactions such as hydrolysis, causing molecular structure changes.
In conclusion, the physical properties of 2-tert-butoxycarbonyl amino-thiazole-5-carboxylic acid ethyl ester are of great significance in the fields of organic synthesis and drug development. According to their properties, researchers can rationally design the synthesis route, select the appropriate reaction solvent and determine the appropriate storage conditions.

The synthesis method of 2-tert-butoxycarbonyl amino-thiazole-5-carboxylic acid ethyl ester involves the technique of organic synthesis. The first method can be started from raw materials containing thiazole structure. First, take the appropriate thiazole derivative, which must have a modifiable group at a specific position in the thiazole ring, such as a halogen atom or an active functional group. This derivative is combined with a tert-butoxycarbonyl amination reagent, such as tert-butoxycarbonyl azide (Boc-N 🥰), in a suitable solvent, such as dichloromethane or N, N-dimethylformamide (DMF), and catalyzed by a base, such as triethylamine or potassium carbonate, undergoes a nucleophilic substitution reaction to connect the tert-butoxycarbonyl amino group to the thiazole ring. Then, the resulting intermediate is esterified with an ethyl ester-containing reagent, such as bromoacetate, in an alkaline environment, such as sodium hydride or sodium alcohol, to obtain the target product 2-tert-butoxycarbonyl amino-thiazole-5-carboxylate ethyl ester.
Another method is to construct a thiazole ring first. Sulfur-containing compounds and nitrogen-containing compounds, such as thiourea and α-halocarbonyl compounds, are cyclized under appropriate reaction conditions, such as heating and in alcohol solvents, to form a thiazole ring. After the thiazole ring product is isolated and purified, the tert-butoxycarbonyl protection of the amino group and the ethylation of the carboxyl group are sequentially modified. The amino group is first protected by the tert-butoxycarbonylation reagent, and then esterified with ethanol and an appropriate dehydrating agent, such as concentrated sulfuric acid or dicyclohexyl carbodiimide (DCC), to finally synthesize 2-tert-butoxycarbonyl amino-thiazole-5-carboxylate ethyl ester. Each synthetic method has its own advantages and disadvantages, and the practical operation needs to be carefully selected according to factors such as the availability of raw materials, reaction conditions and yield.

Ethyl 2-tert-butoxycarbonyl amino-thiazole-5-carboxylate is a chemical substance commonly used in organic synthesis. During storage and transportation, many matters need to be paid attention to.
First words Storage, because of its nature or affected by external factors, should be placed in a cool, dry and well-ventilated place. Avoid high temperatures, which can easily cause it to decompose or cause other chemical reactions, which will damage its quality. Also keep away from fire sources and oxidants, which may be flammable or react violently with oxidants, endangering safety. It needs to be sealed and stored to prevent moisture and air from invading, because moisture or hydrolysis, air or oxidation.
As for transportation, choose the appropriate packaging material according to its chemical characteristics. Make sure that the packaging is sturdy and can withstand the vibration and collision during transportation, so as not to leak. The transportation vehicle should also be clean and free of other chemical residues to avoid adverse reactions with it. Transportation personnel must be professionally trained to be familiar with the dangerous characteristics of this chemical and emergency disposal methods. Check the packaging condition on the way. If there is any abnormality such as leakage, deal with it quickly according to the plan. In this way, the safety of 2-tert-butoxycarbonyl amino-thiazole-5-carboxylate ethyl ester during storage and transportation is guaranteed.

I think what you are asking is about the market price range of 2-tert-butoxycarbonyl amino-thiazole-5-carboxylic acid ethyl ester. However, the price of this chemical often changes due to many factors.
First, quality is the key. Those with high purity and few impurities will have a higher price than those with ordinary quality. If used in high-end scientific research and pharmaceutical synthesis, the purity requirements are extremely high, and the price is not cheap.
Second, the trend of supply and demand also has an impact. If the market demand for this chemical is strong and the supply is limited, the price will rise; conversely, if the supply exceeds the demand, the price will decline.
Third, the amount of purchase is related to the price. A large number of purchasers can often get preferential prices, which can reduce the seller's cost due to scale effects.
Fourth, the source is also related to the origin. Importers may have higher prices than domestic products due to customs duties, transportation and other costs. And the cost of processes and raw materials in different origins is different, resulting in different prices.
Generally speaking, the price of this chemical may range from tens to hundreds of yuan per gram. If it is industrial grade and slightly lower purity, it may cost tens of yuan per gram; if it is scientific research grade and high purity, it may cost hundreds of yuan per gram. However, this is only a rough range. The actual price needs to be consulted with the chemical supplier and the above factors are comprehensively considered before the exact price can be obtained.