2-tert-ButoxycarbonylaMino-4,5,6,7-tetrahydro-benzothiazole-6-carboxylic acid ethyl ester

2-tert-butoxycarbonyl amino-4,5,6,7-tetrahydrobenzothiazole-6-carboxylic acid ethyl ester, which has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate to synthesize compounds with specific biological activities. For example, when developing new antibacterial drugs, its structural properties may interact with specific bacterial targets, and after modification and transformation, the final product with antibacterial activity is obtained. In the field of organic synthesis, due to its unique molecular structure, it can participate in many complex organic reactions and construct more complex organic molecular structures. For example, in the construction of a fused ring compound system, by virtue of the active groups it contains, through cyclization, substitution and other reactions, the complexity and diversity of molecules are expanded, providing a basis for the synthesis of new functional materials. In the process of drug development, the physical and chemical properties, biological activities and pharmacokinetic properties of compounds can be adjusted by optimizing and modifying their structures, and the birth of innovative drugs can be promoted.

To prepare 2-tert-butoxycarbonyl amino-4,5,6,7-tetrahydro-benzothiazole-6-carboxylic acid ethyl ester, the method is as follows:
First, the appropriate starting material is taken, with tetrahydro-benzothiazole as the group, and the corresponding group is introduced at a specific position. Usually, compounds containing amino groups are reacted with tert-butoxycarbonylation reagents, which is a key step in the formation of tert-butoxycarbonyl amino groups. Under suitable reaction conditions, tert-butoxycarbonylation reagents such as di-tert-butyl dicarbonate can undergo nucleophilic substitution reactions, and the hydrogen on the amino group is replaced by tert-butoxycarbonyl.
Furthermore, to obtain the 6-carboxylic acid ethyl ester group, a raw material containing a carboxyl group or its active derivative can be selected to react with ethanol in the presence of a condensation reagent to generate the corresponding carboxylic acid ethyl ester. For example, 6-carboxyl-4,5,6,7-tetrahydro-benzothiazole derivatives and ethanol are esterified under the action of condensation reagents such as dicyclohexylcarbodiimide (DCC) and 4-dimethylaminopyridine (DMAP).
During the reaction process, it is necessary to pay attention to the control of the reaction conditions. Temperature is crucial, and the temperature required for different reaction steps varies. For example, the tert-butoxycarbonylation reaction is often carried out at low temperature to room temperature to ensure the selectivity and yield of the reaction. The esterification reaction depends on the specific raw material and reagent activity, or moderate heating is required to promote the reaction process. The choice of reaction solvent should not be underestimated. Aprotic solvents such as dichloromethane, N, N-dimethylformamide (DMF), etc., are often used in the tert-butoxycarbonylation reaction because they can dissolve raw materials and reagents and have no interference with the reaction. In the esterification reaction, organic solvents such as toluene can provide a good reaction environment and help the product to form.
After the reaction is completed, the separation and purification of the product are essential. Commonly used column chromatography, according to the polarity difference between the product and the impurity, select the appropriate eluent, and separate and purify the product from the reaction mixture to obtain high purity 2-tert-butoxycarbonyl amino-4,5,6,7-tetrahydro-benzothiazole-6-carboxylic acid ethyl ester.

2-tert-butoxycarbonylamino-4,5,6,7-tetrahydrobenzothiazole-6-carboxylic acid ethyl ester, which is one of the organic compounds. Its physical and chemical properties are quite important, and are related to many chemical processes and practical applications.
Discussing physical properties, under normal temperature and pressure, its properties are usually solid, or due to differences in crystal structure, its appearance is white to white powder, which is a common state. The melting point is the inherent characteristic of the substance. The melting point of the compound is about a certain range (although the specific value needs to be accurately determined by experiments). At the melting point temperature, the solid state turns to liquid state, and the intermolecular force changes. Its solubility is also a key property. In organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), it has a certain solubility. This property makes it uniformly dispersed in the organic synthesis reaction system, which is conducive to the reaction. In water, the solubility is lower, because its molecular structure contains hydrophobic groups, which have weak interaction with water molecules.
In terms of chemical properties, its molecular structure contains tert-butoxycarbonyl amino, which has certain reactivity. Under specific conditions, in case of acid or base, tert-butoxycarbonyl can undergo a deprotection reaction, releasing amino groups, and then participate in subsequent condensation, substitution and other reactions, which play an important role in the construction of complex molecular structures. Furthermore, the benzothiazole ring system endows it with a special electron cloud distribution, which affects the reaction check point and activity of the molecule. Its 6-position carboxylic acid ethyl ester group can undergo hydrolysis reaction under basic conditions to generate corresponding carboxylic acids. In case of alcohols and catalysts, it can also undergo transesterification reaction to achieve structural modification and generate different ester derivatives to meet diverse chemical needs.

I don't know what the market price of 2-tert-butoxycarbonyl amino-4,5,6,7-tetrahydrobenzothiazole-6-carboxylic acid ethyl ester is. This compound is unusual and common, and its price may vary due to many factors.
First, the difficulty of production and preparation has a great impact. If the synthesis of this compound requires complex steps, rare raw materials, or strict requirements for reaction conditions, such as high temperature, high pressure, special catalysts, etc., the production cost will be high and the price will be high.
Second, the market demand situation is also the key. If this compound is widely used in medicine, chemical industry and other fields, the demand is strong, but the supply is limited, the price tends to be higher; conversely, if the demand is low, the price may be relatively low.
Third, supplier differences also lead to different prices. Different manufacturers have different production processes and cost control capabilities, and pricing will also be different. Large manufacturers may have slightly lower costs due to scale effects, but their brand, quality and other factors may also change the price.
In books such as "Tiangong Kaiwu", the price of this product is not included, because it is a modern chemical synthesis product, and it was not available in ancient times. To know its exact price today, you need to consult chemical raw material suppliers, chemical reagent sales platforms, or communicate in relevant industry forums to obtain more accurate price information.

2-tert-butoxycarbonylamino-4,5,6,7-tetrahydro-benzothiazole-6-carboxylic acid ethyl ester, this is an organic compound. Its storage conditions are critical to the stability and quality of the compound.
This compound should be stored in a cool, dry and well-ventilated place. A cool environment can slow down the chemical reaction rate and avoid decomposition or deterioration due to excessive temperature. Dry conditions are also indispensable. Due to moisture or adverse reactions such as hydrolysis, the structure and properties of the compound are damaged. Good ventilation can disperse volatile substances that may accumulate in time to prevent the formation of flammable and explosive environments.
Furthermore, it should be stored separately from oxidants, acids, alkalis and other chemicals. Due to its chemical properties or violent reactions with these substances, it is dangerous. When storing, make sure that the container is well sealed to prevent air and moisture from invading.
After the compound is taken, the container should be sealed in time to reduce its contact time with the external environment. In addition, the storage area should be equipped with corresponding fire protection and leakage emergency treatment equipment to deal with emergencies.
Properly store this compound and follow the above storage conditions to maintain its chemical stability and quality to the greatest extent and ensure the desired effect in subsequent use.