2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylic acid

2-% 5B% 28tert - butoxycarbonyl%29amino%5D - 1,3 - thiazole - 5 - carboxylic acid, Chinese name or 2 - [ (tert-butoxycarbonyl) amino] - 1,3 - thiazole - 5 - carboxylic acid. This compound has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
View the art of organic synthesis, and want to form complex and delicate organic molecules, this compound often plays a role. Its unique structure of thiazole ring and tert-butoxycarbonyl amino and carboxylic groups endows it with active reactivity. In the construction of drug molecules containing thiazole structure, it is often used as a starting material, and through delicate reactions, such as acylation, amination, etc., it is ingeniously converted and integrated into the target molecular structure, just like a skilled craftsman building a magnificent building with exquisite parts.
In the field of pharmaceutical chemistry, this compound also has extraordinary power. Many biologically active lead compounds contain their structural fragments. Because it can provide a variety of interaction check points, fit with biological targets, or form hydrogen bonds, or generate van der Waals forces, and then regulate biomolecular functions. For example, when developing antibacterial and anti-inflammatory drugs, based on them, through structural modification and optimization, or finding innovative drugs with high efficiency and low toxicity, it is like searching for a bright pearl in the vast sea of drugs.
In the field of materials science, although it is not as widely used as the first two, it still has potential value. Or because of its specific chemical structure, it endows materials with unique properties, such as improving the stability and solubility of materials, which is like adding unique treasures to the treasure house of materials science, waiting for craftsmen to explore and utilize.

2-% 5B% 28tert - butoxycarbonyl%29amino%5D - 1,3 - thiazole - 5 - carboxylic acid, that is, 2- [ (tert-butoxycarbonyl) amino] -1,3 - thiazole - 5 - carboxylic acid, its synthesis method is as follows:
The starting material is often selected to contain compounds with thiazole ring structure and modifiable groups in suitable positions. For example, with 5 - halo - 1,3 - thiazole - 2 - amine as the starting material, the amino group is first protected by tert-butoxycarbonyl (Boc). In this step, 5-halo-1,3-thiazole-2-amine is dissolved in a suitable organic solvent, such as dichloromethane, and a dichloromethane solution containing Boc acid anhydride is slowly added dropwise at low temperature, and an organic base, such as triethylamine, is added to neutralize the acid generated by the reaction to promote the positive progress of the reaction. The reaction process needs to be monitored, and thin layer chromatography (TLC) is commonly used to track it. When the raw material point disappears, it indicates that the Boc protection reaction of the amino group is completed.
Subsequently, the halogen atom at the 5-position of the thiazole ring is carboxylated. The reaction path involving metal reagents is generally used, such as reacting the product after protecting the amino group with magnesium chips in anhydrous ether to make Grignard reagent. After that, carbon dioxide gas is slowly introduced at low temperature, and carbon dioxide and Grignard reagent undergo nucleophilic addition reaction to form carboxylate intermediates. After the reaction is completed, the carboxylate is acidified by dilute acid aqueous solution to convert the carboxylate into the target 2- [ (tert-butoxycarbonyl) amino] -1,3-thiazole-5-carboxylic acid.
Another possible synthesis strategy is to use 2-amino-1,3-thiazole-5-carboxylic acid as the starting material. First, 2-amino-1,3-thiazole-5-carboxylic acid and Boc anhydride are mixed in a suitable solvent, such as N, N-dimethylformamide (DMF), and an appropriate amount of organic base, such as 4-dimethylaminopyridine (DMAP), is added as a catalyst. After a period of reaction, Boc protection of the amino group can be completed, resulting in the target product 2-[ (tert-butoxycarbonyl) amino] -1,3-thiazole-5-carboxylic acid. This method is relatively direct and avoids the strict requirements of anhydrous and anaerobic conditions in the preparation of Grignard reagents, but the acquisition of the starting material 2-amino-1,3-thiazole-5-carboxylic acid may be difficult, and the appropriate synthesis route needs to be selected according to the actual situation.

2-% 5B% 28tert - butoxycarbonyl%29amino%5D - 1% 2C3 - thiazole - 5 - carboxylic acid is one of the organic compounds. Its physical and chemical properties are worth exploring.
In terms of appearance, it is often white to white-like solid. This is due to the characteristics of its molecular structure, resulting in a specific pattern of intermolecular forces, resulting in this appearance. Its melting point is also an important physical property. Generally, within a certain temperature range, due to the force of intermolecular interactions, the lattice structure disintegrates at this temperature, and the substance changes from solid to liquid. < Br >
In terms of solubility, it has certain solubility in common organic solvents, such as dichloromethane, N, N-dimethylformamide, etc. This is because the compound molecule and the organic solvent molecule can form interactions such as van der Waals force, hydrogen bond, etc. Therefore, it is soluble. However, the solubility in water is poor, because the molecular polarity does not match the polarity of the water molecule well, and some groups in the molecule have strong hydrophobicity.
Chemically, the carboxyl group it contains is acidic and can neutralize with the base to form the corresponding salt. This carboxyl group is a typical chemical behavior. Due to the electronegativity difference of the oxygen atom in the carboxyl group, the hydrogen atom is easy to dissociate. At the same time, the amino part of the molecule (tert-butoxycarbonyl) also has specific reactivity. Under suitable conditions, reactions such as deprotection can occur, showing important intermediate properties in organic synthesis. The various physical and chemical properties of this compound lay the foundation for its application in many fields such as organic synthesis and medicinal chemistry.

There is a question today, what is the market price of 2- [ (tert-butoxycarbonyl) amino] -1,3-thiazole-5-carboxylic acid. However, this question is difficult to answer quickly. The price of this compound varies for many reasons.
First, the quality is very important. The quality is good, the price is high; the quality is inferior, the price is low. Second, the purchase quantity also has an impact. If you buy in bulk, the merchant may give a discount, the price should be lower; if you buy only a small amount, the price may be higher. Third, the state of supply and demand determines its price. The market needs urgently, and if the supply is small, the price will go up; if the supply exceeds the demand, the price may go down. < Br >
The domain used in this compound also involves its price. For scientific researchers, the quality requirements are high, and the price may be expensive; for industrial production, consider the cost, price or difference. And in different places, there is a difference in prices, and the price also varies from place to place.
Therefore, in order to know the exact price, it is necessary to carefully observe the market situation and consult the merchants to obtain a more accurate price.

2-% 5B% 28tert - butoxycarbonyl%29amino%5D - 1,3 - thiazole - 5 - carboxylic acid is an organic compound with a unique chemical structure. Its storage conditions are critical to the stability and quality of this compound.
According to the concept of "Tiangong Kaiwu", everything needs to be stored in a suitable place, and this compound is no exception. Due to its chemical properties, it needs to be stored in a cool, dry and well-ventilated place. Avoid direct sunlight, due to light or photochemical reactions caused by it, its structure and properties are damaged.
Temperature should be controlled within a specific range, usually 2-8 ° C. High temperature or cause the compound to decompose and deteriorate, such as extreme heat in summer. If the compound is placed in a high temperature, its chemical properties may change drastically.
Humidity should also be paid attention to. If the humidity is too high, it is easy to cause the compound to absorb moisture, or cause reactions such as hydrolysis. Therefore, it should be stored in a dry environment, and a desiccant can be used to maintain the dry environment.
And it needs to be stored separately from oxidants, acids, alkalis and other substances, because it may chemically react with these substances. If it coexists with strong oxidants, it may cause a violent reaction, endangering safety and damaging the compound itself.
When storing, it should be stored in a sealed container to prevent contact with air and avoid being oxidized or absorbed by the components in the air and deteriorating. In this way, 2-5B% 28tert - butoxycarbonyl%29amino%5D - 1,3 - thiazole - 5 - carboxylic acid should be properly preserved to ensure its quality and stability.