2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-4-carboxylate

2-% 5B% 28tert - butoxycarbonyl%29amino%5D-1%2C3 - thiazole - 4 - carboxylate, Chinese name or 2 - [ (tert-butoxycarbonyl) amino] -1,3 - thiazole - 4 - carboxylate. This substance is used in the field of pharmaceutical and chemical industry and has a wide range of uses.
It is often a key intermediate in drug synthesis. Due to its unique structure, thiazole ring has good biological activity and stability, tert-butoxycarbonyl amino can protect amino groups, which can be precisely regulated in subsequent reactions, guide the reaction in a predetermined direction, and synthesize drug molecules with specific structures and functions. Such as the creation of antibacterial, anti-inflammatory, and anti-tumor drugs, it can be seen helping.
In the field of organic synthesis, it is an important building block that can be used to build complex organic molecular structures through various chemical reactions. By reacting with other organic reagents, carbon-carbon bonds and carbon-hetero bonds can be formed, enriching the diversity of molecules and laying the foundation for the research and development of new materials and bioactive substances.
Furthermore, in the exploration of chemical research, this compound can be used as a model molecule to help researchers gain insight into chemical reaction mechanisms and intermolecular interactions. By studying its reaction characteristics and physicochemical properties, it provides ideas and basis for the development of new synthesis methods and strategies, and promotes the development and evolution of organic chemistry, medicinal chemistry and other disciplines.

To prepare 2 - [ (tert-butoxycarbonyl) amino] -1,3-thiazole-4-carboxylate, there are three methods.
One is to start with 4-bromo-2-chloromethyl-1,3-thiazole, first meet with the tert-butoxycarbonyl amino reagent, and undergo nucleophilic substitution, so that the chloromethyl group is replaced by the tert-butoxycarbonyl amino group. Later, the carboxyl group is formed into a salt at the base, and the target 2 - [ (tert-butoxycarbonyl) amino] -1,3-thiazole-4-carboxylate can be obtained. In this way, the starting material is easy to obtain, and the method of nucleophilic substitution is also familiar. However, there may be by-products in the reaction, so the reaction situation needs to be well controlled to increase the yield and purity.
The second is to use 2-amino-1,3-thiazole-4-carboxylic acid as the group, so that it encounters the tert-butoxycarbonylation reagent and undergoes the change of the tert-butoxycarbonylation of the amino group. Tert-butoxycarbonylation reagents, such as di-tert-butyl dicarbonate, can react well with the amino group when stored in an appropriate base. After forming 2- [ (tert-butoxycarbonyl) amino] -1,3-thiazole-4-carboxylic acid, it reacts with the base to form the carboxyl group into a salt to obtain the target salt. This path starts with 2-amino-1,3-thiazole-4-carboxylic acid, and the reaction step is simple, but the 2-amino-1,3-thiazole-4-carboxylic acid or the valence is high, and the source is trapped.
The third is to start with the construction of thiazole ring. For example, the raw materials containing sulfur and nitrogen are condensed and cyclized to form 1,3-thiazole ring. After cyclization, the tert-butoxycarbonyl amino group and carboxyl group are introduced at the appropriate position to form carboxylate. This way, it can start from the basic raw material, adjust according to the needs, and then the reaction is complex. The conditions are harsh. It is necessary to control each step of the reaction to ensure the final high purity of 2 - [ (tert-butoxycarbonyl) amino] -1,3 -thiazole-4 -carboxylate.
All synthesis methods have advantages and disadvantages. The choice of time depends on the availability of raw materials, the level of cost, the yield and purity, and the difficulty of reaction.

2-% 5B% 28tert - butoxycarbonyl%29amino%5D-1%2C3 - thiazole - 4 - carboxylate is an organic compound whose physicochemical properties are crucial for its application in many fields.
When it comes to physical properties, this compound is usually in a solid state due to intermolecular forces. Its melting point depends on the regularity of the molecular structure and the strength of the interaction. If the molecules are arranged in an orderly manner and the interaction is strong, the melting point is higher; otherwise, it is lower. The appearance may be white to light yellow powder, which is related to its molecular structure and the functional groups it contains, which affect the absorption and reflection of light.
As for the chemical properties, the (tert-butoxycarbonyl) amino functional groups it contains have certain reactivity. ( Tert-butoxycarbonyl) is relatively stable, and under specific conditions, it can deprotect and release amino groups, which can then participate in reactions such as amidation. The 1,3-thiazole ring system endows the compound with unique chemical properties. The ring has certain aromaticity and can participate in electrophilic substitution reactions. Its 4-carboxylate part is acidic, which can react with bases to form salts, and can also participate in esterification reactions. Under the action of catalysts with alcohols, the corresponding ester compounds are formed.
In summary, the physicochemical properties of 2-5B% 28tert-butoxycarbonyl%29amino%5D-1%2C3-thiazole-4-carboxylate make it show potential application value in organic synthesis, medicinal chemistry and other fields. Studying its properties will help to expand the development of related fields.

In today's world, the business situation is complicated, and the price of things that are easy to change in the market is not constant, and it mostly changes due to various reasons. As for 2 - [ (tert - butoxycarbonyl) amino] -1,3 - thiazole - 4 - carboxylate, the price of this agent in the market is difficult to determine.
Watching the colonization of goods in the past, the fluctuation of price is related to supply and demand, the difficulty of production, the price of materials, or the guidance of government orders, and the change of times. The manufacture of this agent, if the raw materials used are easily available, the preparation method is simple, and the market is not prosperous, the price may be slightly cheaper. On the contrary, if the raw materials are rare, difficult to make, and there are many people who need them, the price will be high.
And in the cities of the four directions, the price is also different. In Dayi, Kyoto, merchants converge, things are gathered and competitive, and the price may be flat. In remote places, it is difficult to transfer, and the price may increase. In addition, the rise and fall of the city, and the prosperity of the year are all related to the price.
Therefore, if you want to know the exact market price of this agent, you can get the approximate price range when you visit the pharmaceutical shops and chemical companies in various cities, inquire about the industry, and observe the changes in the market. Although it is difficult to determine the range of its price, through these various paths, you can see the trend of its price.

2-% 5B% 28tert - butoxycarbonyl%29amino%5D-1%2C3 - thiazole - 4 - carboxylate is one of the organic compounds. Its stability is related to many aspects. In the structure of this compound, the thiazole ring is the core part, which has certain rigidity and stability. However, the substituents attached to the ring, such as the 2-position (tert-butoxycarbonyl) amino group, have a great impact on its stability.
Tert-butoxycarbonyl amino group has a certain steric resistance effect, which can protect the amino group to a certain extent, and because of its large tert-butyl structure, it can affect the interaction between molecules, which in turn affects the overall stability. At the same time, the 4-position carboxyl group (or its corresponding ester group form) also participates in the electron cloud distribution of molecules and intermolecular interactions.
Under different environmental conditions, its stability varies. In a dry environment at room temperature and pressure, the structure of the compound is relatively stable, and the interaction between molecules is maintained in a certain equilibrium state. However, in case of high temperature, humidity or specific chemical reaction conditions, the stability may be affected.
Under high temperature, the thermal motion of the molecule intensifies, or the vibration of the chemical bond within the molecule is enhanced. If the energy is sufficient, or the chemical bond is broken, such as the tert-butoxycarbonyl part, at high temperature and in the presence of a specific catalyst, or a deprotection reaction occurs, resulting in the exposure of the amino group, thereby changing the chemical properties and stability of the molecule.
In a humid environment, water may participate in chemical reactions, interact with carboxyl groups or other active checking points, such as hydrolysis, thereby destroying the original structure of the molecule and reducing its stability. In addition, if it encounters specific acid-base conditions, it will also have a significant impact on its stability. Under acidic conditions, tert-butoxycarbonyl is prone to protonation and departure; under basic conditions, the carboxyl group or its ester group part or hydrolysis and other reactions are not conducive to the stable existence of the compound.
In summary, the stability of 2-% 5B% 28tert - butoxycarbonyl%29amino%5D-1%2C3 - thiazole - 4 - carboxylate depends not only on its own molecular structure, but also on external environmental conditions. In practical application and storage, these many factors need to be fully considered to ensure the stability of its properties.