2-((S)-1-tert-butoxycarbonyl-pyrrolidin-2-yl)-thiazole-4-carboxylic acid ethyl ester

This is the structural analysis of organic compounds. 2 - ((S) -1 -tert-butoxycarbonyl-pyrrolidine-2-yl) thiazole-4 -carboxylate ethyl ester, according to its name, can be analyzed step by step according to functional groups and structural fragments.
"2 -" The epitope is at a specific position in the main chain or ring, which means that there is a substitution at the 2 position of the thiazole ring. " Thiazole-4-ethyl carboxylate ", thiazole is a five-membered heterocyclic ring containing sulfur and nitrogen, with a functional group of ethyl carboxylate at the 4th position. This ester group is obtained from the ester of carboxyl group and ethanol, and has specific chemical activity and reaction check point.
" ((S) -1 -tert-butoxycarbonyl-pyrrolidine-2 -yl) ", (S) Chiral central configuration, which is a specific spatial orientation. Pyrrolidine is a five-membered nitrogen-containing heterocycle with a tert-butoxycarbonyl at one position. This group is often used as an amino protecting group, which can protect the amino group in organic synthesis and prevent its accidental reaction in the reaction. The second position is connected to the second position of the thiazole ring to construct a complex molecular structure.
Overall, this compound is constructed from a thiazole ring and a pyrrolidine ring through specific connections and substituents. The synergy of each part endows it with unique chemical properties and potential applications. It may be of great significance in organic synthesis, pharmaceutical chemistry and other fields, because different functional groups and chiral centers may affect their interaction with biological targets and chemical reactivity.

(2 - (S) -1 -tert-butoxycarbonyl-pyrrolidine-2-yl) thiazole-4-carboxylic acid ethyl ester) is widely used. In the field of organic synthesis, it is often used as a key intermediate. Its unique structure, containing specific groups, can build complex organic molecular structures through various chemical reactions, which is of great significance in pharmaceutical chemistry research.
In drug development, many active compound synthesis depends on this intermediate. By modifying and modifying its structure, drug molecules with novel pharmacological activities can be created. Due to its thiazole and pyrrolidine structures, it can specifically bind to targets in vivo, or become potential drug lead compounds, laying the foundation for the development of new drugs.
In the field of materials science, or through special reactions, polymer is introduced to endow materials with unique properties, such as improving material stability, solubility or optical properties, etc., to expand the application range of materials.
In chemical production practice, it can be used as a synthetic block. Through different reaction paths, a series of derivatives can be synthesized to meet different industrial and scientific research needs. With its unique chemical structure, this compound has shown important application value in many fields, providing strong support for organic synthesis, drug research and development and materials science progress.

There are various ways to prepare ((S) -1 -tert-butoxycarbonyl-pyrrolidine-2-yl) thiazole-4-carboxylate ethyl ester.
First, (S) -1 -tert-butoxycarbonyl-pyrrolidine-2-one can be started. First, a suitable nucleophile, such as a sulfur-containing nucleophile, launches a nucleophilic attack on its carbonyl group to form a thiazole ring precursor. After the esterification step, ethanol and suitable esterification reagents are selected to promote the reaction of carboxylic acid with ethanol under appropriate reaction conditions, such as acid catalysis or the presence of a condensing agent, to form the ethyl ester structure of the target product. During this process, attention should be paid to the precise control of reaction conditions, such as temperature, pH, etc., to prevent the growth of side reactions and ensure that the stereochemistry of the (S) -configuration can be maintained.
Second, ethyl thiazole-4-carboxylate can also be used. The substrate is reacted with (S) -1 -tert-butoxycarbonyl-2 -halopyrrolidine, and the halogen atom is replaced by pyrrolidine through nucleophilic substitution reaction to achieve the construction of the target molecule. In this path, the choice of solvent is very critical, and it is necessary to choose the one with good solubility of the substrate and the reaction intermediate and does not interfere with the reaction process. At the same time, the amount and strength of the base also need to be carefully considered to help the nucleophilic substitution reaction occur smoothly without causing adverse consequences such as racemization.
Or, using (S) -pyrrolidine-2-amine as raw material, first react with tert-butoxycarbonyl protection reagent to protect the amino group to obtain (S) -1 -tert-butoxycarbonyl-pyrrolidine-2-amine. Then react with halogenates or activated esters containing thiazole-4-carboxylate structure, and undergo nucleophilic substitution to obtain the target product. In this route, it is extremely important to optimize the conditions of the protection and deprotection steps, not only to ensure effective protection of amino groups and subsequent smooth removal, but also to ensure that the entire reaction process is efficient and selective.

(2 - (S) -1 -tert-butoxycarbonyl-pyrrolidine-2-yl) thiazole-4-carboxylic acid ethyl ester) This compound has many physicochemical properties. Its appearance is often white to off-white solid. Due to the interaction of various groups in the molecular structure, the molecules are arranged in an orderly manner to form a specific crystal form or amorphous form.
In terms of solubility, the compound is difficult to dissolve in water. Because its molecules are mostly hydrophobic groups, such as tert-butoxycarbonyl and thiazole rings, etc., it has weak interaction with water molecules and is difficult to form hydrogen bonds with water. However, it can be soluble in common organic solvents, such as dichloromethane, chloroform, tetrahydrofuran, etc. Because these organic solvents and compound molecules can interact with each other through van der Waals forces to achieve mutual solubility.
Its melting point is also an important physical property. Due to the existence of hydrogen bonds, van der Waals forces and other interactions between molecules, specific energies are required to overcome these effects to achieve crystal transformation, so there is a specific melting point range. The specific value is affected by molecular purity and crystallization conditions.
In terms of chemical properties, there are multiple active check points in the molecule. The nitrogen and sulfur atoms of the thiazole ring have certain nucleophilic properties and can participate in nucleophilic substitution and other reactions. The ester group can undergo hydrolysis reaction, and under the catalysis of acid or base, the corresponding carboxylic acid and alcohol are formed. The tert-butoxycarbonyl on pyrrolidine ring can be removed under certain conditions to further modify the molecular structure and realize functionalization. These properties are determined by the electron cloud distribution and spatial structure of specific chemical bonds and groups in the molecule.

I do not know the price of "2- ((S) -1-tert-butoxycarbonyl-pyrrolidin-2-yl) thiazole-4-carboxylic acid ethyl ester" in the market. The price of this product often varies due to various reasons, such as its purity, source, and market supply and demand. If its purity is extremely high, the source is regular, and the market needs to be prosperous and the supply is small, the price will be high; conversely, if it is pure and miscellaneous, and the market supply is large and the demand is small, the price will be low.
In addition, if you want to confirm the price, you should consult the suppliers of chemical raw materials, the sellers of chemical reagents, or visit the relevant chemical product trading platforms. In these ways, you can get the exact price in the near future. However, I have not been involved in such commercial information today, so it is difficult to understand its price in the market. If you want to know the details, you can follow the above path.