What are the main uses of 2- (p-Aminophenyl) -6-methylbenzothiazole?

2-% 28p - Aminophenyl% 29 - 6 - methylbenzothiazole, the Chinese name is often 2 - (p-aminophenyl) -6 - methylbenzothiazole. This compound is widely used in the field of medicine and can be used as a key intermediate in drug synthesis. In the process of many drug development, it can be cleverly combined with other compounds through specific chemical reactions to construct molecules with specific pharmacological activities, which can be used for the prevention and treatment of diseases.

In the field of materials science, it also shows important value. It can be used to prepare functional materials, such as organic optoelectronic materials. Due to its molecular structure imparting special photoelectric properties, it can be used in the manufacture of organic Light Emitting Diode (OLED), solar cells and other devices to improve the performance of the device, such as improving the luminous efficiency and enhancing the photoelectric conversion efficiency.

In the dye industry, 2 - (p-aminophenyl) -6 -methylbenzothiazole also occupies a place. With its own structural characteristics, it can be used as a raw material for synthesizing new dyes, adding unique colors and properties to the dyes, such as improving the light resistance and washable properties of the dyes, to meet the diverse needs of dyes in different fields.

Furthermore, in the field of chemical research, it is often regarded as a model compound. Through in-depth exploration of its chemical reaction characteristics, molecular structure and properties, researchers can acquire more basic theoretical knowledge in the field of organic chemistry, providing support and reference for the exploration of new synthesis methods and reaction mechanisms.

What are the physical properties of 2- (p-Aminophenyl) -6-methylbenzothiazole

2-% 28p - Aminophenyl% 29 - 6 - methylbenzothiazole, which is 2 - (p-aminophenyl) -6 - methylbenzothiazole, has unique physical properties.

Its appearance is often crystalline, and its color is almost white to light yellow. The crystalline morphology is regular, reflecting the orderly arrangement of molecules. From the perspective of the melting point, it changes from solid state to liquid state at a specific temperature of about 150 - 155 ° C. The melting point is an important basis for the identification of this compound.

In terms of solubility, it shows a certain solubility in organic solvents such as ethanol and dichloromethane. Due to the principle of similar miscibility, its molecular structure has a certain affinity with organic solvents. However, the solubility in water is not good, because its molecular structure contains more hydrophobic parts, benzothiazole ring and phenyl are hydrophobic groups, making it difficult to form an effective interaction with water.

2- (p-aminophenyl) -6-methylbenzothiazole has certain stability and can be stored for a long time under conventional conditions. In case of strong acids and bases, the structure or affected, the nitrogen atom on the amino group and benzothiazole ring can react with acid and base. At the same time, it has a certain tolerance to light and heat, but high temperature and strong light environment may still cause it to decompose and other reactions, which affect the chemical stability.

In addition, the compound has absorption characteristics under ultraviolet light. Due to the existence of a conjugated system in the molecule, the conjugated π electrons can absorb ultraviolet light of a specific wavelength and generate absorption peaks at specific positions in the ultraviolet spectrum, which provides convenience for analysis and detection.

Is 2- (p-Aminophenyl) -6-methylbenzothiazole chemically stable?

2-% 28p-Aminophenyl% 29-6-methylbenzothiazole is one of the organic compounds. To discuss the stability of its chemical properties, its molecular structure needs to be observed. This compound contains benzothiazole ring and p-aminophenyl, benzothiazole ring has certain aromaticity, which endows it with certain chemical stability. In the aromatic system, the electron cloud distributes out of the region, which reduces the molecular energy and stabilizes the structure.

The amino group of p-aminophenyl has certain reactivity and can participate in nucleophilic substitution and other reactions. However, due to the conjugation effect of benzene ring, the electron cloud density is dispersed and the activity is not very high. The methyl group is attached to the benzothiazole ring, and the methyl group is the power supply group, which can affect the distribution of electron clouds on the ring, increase the density of the ring electron cloud, and enhance the molecular stability to a certain extent.

However, when encountering strong oxidizing agent, strong acid, strong base and other conditions, its stability may be challenged. If strong oxidizing agent can cause amino oxidation, benzothiazole ring may also be damaged. Under strong acid and strong base conditions, the chemical bonds between amino groups and atoms on the ring may be broken or rearranged.

Overall, 2-% 28p - Aminophenyl% 29-6 - methylbenzothiazole has certain chemical stability under conventional conditions, but under special extreme conditions, the stability will be affected.

What are the synthesis methods of 2- (p-Aminophenyl) -6-methylbenzothiazole

To prepare 2 - (p-aminophenyl) -6 -methylbenzothiazole, there are many methods, each has its own advantages and disadvantages, and varies according to the raw materials and conditions. The common ones are selected and described.

First, p-nitroaniline and 2-methyl-6-aminobenzothiazole are used as starting materials. First, p-nitroaniline is diazotized, and sodium nitrite and hydrochloric acid are used as agents to form diazo salts at low temperature. Then it is coupled with 2-methyl-6-aminobenzothiazole and catalyzed by copper salt in a weakly basic medium to obtain 2 - (p-nitrophenyl) -6 -methylbenzothiazole. Then iron powder or sodium sulfide is used as a reducing agent to reduce the nitro group to an amino group under acidic or neutral conditions, and the target product is obtained. The raw materials are easy to obtain in this way, but the steps are slightly more complicated, and the steps of diazotization and reduction need to be strictly controlled to prevent by-production.

Second, p-haloaniline and 2-methyl-6-halobenzothiazole are used as groups. Under the catalysis of base and palladium, the Ullmann reaction or similar coupling is carried out. The base can be potassium carbonate, sodium carbonate, etc., and the palladium catalytic system such as tetra (triphenylphosphine) palladium. The two are heated in a suitable solvent, such as N, N-dimethylformamide (DMF), and the halogen atoms are linked to obtain 2- (p-aminophenyl) -6-methylbenzothiazole. This method has good selectivity and high yield, but the palladium catalyst is expensive, and the reaction requires an anhydrous and oxygen-free environment, which requires high operation requirements.

Third, p-aminobenzoic acid and 2-methyl-6-mercaptobenzothiazole are used as raw materials. First, p-aminobenzoic acid is converted into acyl chloride, and thionyl chloride is used as the agent. After condensation with 2-methyl-6-mercaptobenzothiazole to obtain the intermediate. After reduction, cyclization and other steps, the target can be obtained. There are also many steps in this diameter, and toxic thionyl chloride is used, which needs to be properly protected and treated.

2- (p-Aminophenyl) -6-methylbenzothiazole in the market price

There is a question today, what is the market price of 2- (p-aminophenyl) -6 -methylbenzothiazole. This is a special compound in the field of fine chemicals, and its price is affected by many factors, making it difficult to determine directly.

First, the cost of raw materials has a significant impact. If the starting materials required for the preparation of this compound are difficult to obtain, or the market supply is tight and the price is high, the price of the finished product will also rise. If specific basic raw materials such as benzene and thiazole are required in the preparation process, the price fluctuation is directly related to the cost of the target product.

Second, the complexity of the preparation process is also key. If the synthesis route is lengthy, the reaction conditions are harsh, special catalysts, solvents are required, or the reaction equipment is very demanding, such as high temperature, high pressure, high purity environment, etc., it will undoubtedly increase the production cost significantly, resulting in its market price is not low.

Third, the market supply and demand situation has a significant impact. If the compound is in strong demand in the pharmaceutical, materials and other industries, but the supply is limited, the price will rise; on the contrary, if the demand is low, the supply may exceed the demand, the price may decline.

According to the example of "Tiangong Kaiwu" in the past, the price of various things varies from time to place. The same is true today for 2 - (p-aminophenyl) -6 -methylbenzothiazole. To know the exact price, you can consult chemical product suppliers, trade platforms, or relevant industry exhibition information to obtain an accurate estimate.