What is the chemical structure of 2- (p-aminobenzenesulfonamido) thiazole?

2-%28p-aminobenzenesulfonamido%29thiazole is 2- (p-aminobenzenesulfonamido) thiazole, which is a modern chemical name. If its chemical structure is described in the ancient classical style of "Tiangong Kaiwu", it is probably as follows:

The structure of 2- (p-aminobenzenesulfonamido) thiazole, the core of which is the ring of thiazole. The thiazole is a five-membered heterocycle, which is composed of a sulfur atom and a nitrogen atom. At the second position of the thiazole ring, a special group is connected.

This group contains a p-aminobenzenesulfonamido group. The first benzene ring and the benzene ring are six-membered carbon rings, which have unique stability and conjugated structure. In the counterposition of the benzene ring, it is connected with an amino group, which is composed of a nitrogen atom and a dihydrogen atom and is basic.

In addition, the other counterposition of the benzene ring is connected with a sulfonyl group, and the sulfur atom in the sulfonyl group is connected to the dioxygen atom, which has strong electron-absorbing properties. The sulfonyl group is then connected to the amino group to form a sulfonamide structure. This sulfonamide group is connected to the second position of the thiazole ring, thus forming the overall chemical structure of 2- (p-aminobenzenesulfonamido) thiazole.

In this structure, each atom is connected by a covalent bond and interacts, giving this substance unique chemical and physical properties. The thiazole ring endows it with certain biological activity and chemical stability, and the p-aminobenzenesulfonamide group also participates in many chemical reactions, and is used in the fields of medicine, chemical industry, etc. Because of this structure, it shows specific efficacy and use.

2- (p-aminobenzenesulfonamido) What are the main uses of thiazole

2-%28p-aminobenzenesulfonamido%29thiazole is 2- (p-aminobenzenesulfonamido) thiazole, and its main uses are as follows:

In the field of medicine, this compound is mostly used as a key intermediate of antibacterial drugs. The combination of p-aminobenzenesulfonamido and thiazole structure gives it unique antibacterial activity. Taking sulfonamides as an example, 2- (p-aminobenzenesulfonamido) thiazole can be converted into antibacterial drugs such as sulfonamido thiazole, which can effectively inhibit the growth and reproduction of bacteria. It has played an important role in the fight against many bacterial infections in the past, relieving pain and restoring health for patients.

In the field of chemical synthesis, it is often regarded as an important synthetic block. With its own structural characteristics, it can react with many compounds through specific reaction paths to build organic compounds with more complex structures and more diverse functions. Or by reacting with substances containing active groups, chemical bonds such as carbon-nitrogen and carbon-sulfur can be formed, and then dyes, fragrances and functional materials with special properties can be prepared. For example, in the synthesis of some new functional dyes, 2- (p-aminobenzenesulfonamido) thiazole participates in the reaction to introduce a specific structure into the dye molecule and improve the dyeing performance and fastness of the dye.

Scientific research exploration level, because of its unique structure and potential reactivity, is often selected by researchers as a research object. Through in-depth investigation of its chemical reaction mechanism and structure-activity relationship, it can not only deepen the understanding of the basic theory of organic chemistry, but also open up new ideas for new drug research and development, material creation, etc. Researchers modify and transform 2- (p-aminobenzenesulfonamido) thiazole to explore compounds with higher activity and better performance, and promote the continuous development of medicine and materials.

What are the synthesis methods of 2- (p-aminobenzenesulfonamido) thiazole

To prepare 2 - (p-aminobenzenesulfonamido) thiazole, there are many methods. The ancient method, or from the condensation of p-aminobenzenesulfonyl chloride and 2-aminothiazole. First take p-aminobenzenesulfonic acid, and use appropriate chlorinating agents, such as phosphorus pentachloride, thionyl chloride, etc., to make p-aminobenzenesulfonyl chloride. In this step, pay attention to the ratio of reaction temperature, time and material to prevent side reactions. After obtaining p-aminobenzenesulfonyl chloride, add an appropriate amount of acid binding agent, such as triethylamine, to 2-aminothiazole in suitable solvents, such as pyridine and dichloromethane, After the reaction is completed, pure 2 - (p-aminobenzenesulfonamido) thiazole can be obtained by separation and purification, such as crystallization, column chromatography, etc.

There are also those who use paracetamol as the starting material. First, paracetamol is sulfonated, hydrolyzed, chlorinated and other multi-step reactions to obtain p-aminobenzenesulfonyl chloride, and the subsequent condensation method with 2 - aminothiazole is the same as the previous method. Although this path is slightly complicated, the raw materials are easy to obtain, and the cost may be reduced.

Modern methods, or with the help of phase transfer catalysis technology, in condensation reactions, adding phase transfer catalysts, such as tetrabutylammonium bromide, can increase the contact of reactants, improve the reaction rate, reduce the reaction time, and the yield may be improved. There is also a method of using microwave radiation, which can accelerate the molecular movement and cause the reaction to proceed rapidly, which also has considerable effect.

Another attempt to use microbial transformation methods uses specific microorganisms or their enzymes to catalyze the synthesis of related substrates into target products. This green method has the advantages of mild conditions and high selectivity, but it is still in the stage of research and development, and large-scale application will take time. All kinds of methods, each with its own advantages and disadvantages, need to be based on the actual situation, such as the availability of raw materials, the level of cost, the advantages and disadvantages of yield, etc.

2- (p-aminobenzenesulfonamido) What are the physical properties of thiazole

2-%28p-aminobenzenesulfonamido%29thiazole, that is, 2 - (p-aminobenzenesulfonamido) thiazole, the physical properties of this substance are as follows:

Its appearance is often in the state of white or off-white crystalline powder, and the texture is fine. In terms of solubility, it is extremely difficult to dissolve in water, and in organic solvents such as ethanol and acetone, the solubility is also quite limited. This is because of its molecular structure, there are relatively large benzene rings and special thiazole ring structures, and amino groups and sulfonamido groups form a certain intermolecular force, making it difficult to form an effective interaction with water molecules, so water solubility is poor.

Its melting point is in a specific range, about 180-184 ° C. The characteristics of the melting point are closely related to the interaction force between molecules. The π-π stacking between the benzene ring and the thiazole ring, as well as the possible hydrogen bonds between the amino group and the sulfonamide group, jointly maintain the ordered arrangement of the molecules. A specific energy is required to break this ordered structure and realize the transition from solid to liquid, thus presenting a specific melting point.

In addition, its density is about 1.5 g/cm ³. The property of density reflects the mass distribution of the molecule in a unit volume, which is related to the degree of closeness of its molecular structure. The atomic arrangement in the molecular structure of this compound is relatively close, which makes it have this density value.

From the perspective of stability, it has certain stability under normal temperature, pressure and dry environment. However, in strong acid and alkali environment, the sulfonamide group and other parts of its molecular structure may undergo hydrolysis and other reactions, resulting in damaged stability. Under light conditions, due to the existence of unsaturated bonds and benzene ring structures in the molecule, photochemical reactions may be triggered, resulting in structural changes.

2- (p-aminobenzenesulfonamido) What is the application prospect of thiazole in the market?

2-%28p-aminobenzenesulfonamido%29thiazole is 2- (p-aminobenzenesulfonamido) thiazole, which has considerable market application prospects. In the field of medicine, as a key intermediate, it plays an important role in the synthesis of many antibacterial drugs. Today, the demand for antibacterial drugs is like a torrent of water, which is indispensable whether it is hospital treatment and rescue, or animal husbandry and breeding industry to prevent diseases. The antibacterial drugs involved in this intermediate are effective and can deal with a variety of bacterial infections. It is like a sharp blade breaking bamboo, so the market demand continues to rise.

In the chemical industry, 2- (p-aminobenzenesulfonamido) thiazole has also emerged. It can be used to synthesize dyes and pigments with special properties, adding color to chemical products. With the vigorous development of printing and dyeing, coatings and other industries, the demand for special performance dyes and pigments is increasing day by day. With its unique structure and properties, this compound can give dyes and pigments better color fastness, light resistance and other characteristics, just like a strong armor for products, so it has broad application prospects in the chemical industry.

In addition, with the deepening of scientific research and exploration, the research on 2- (p-aminobenzenesulfonamido) thiazole continues to expand. Scientists are like treasure hunters, dedicated to exploring its new properties and application paths. Over time, new application opportunities may be found in cutting-edge fields such as new materials and biomedical engineering, such as opening doors to unknown treasures, and its future application prospects will be even more brilliant, just like the bright stars illuminating the way forward for related industries.