2-methyl-6-nitro-1,3-benzothiazole

2-Methyl-6-nitro-1,3-benzothiazole is widely used. In the chemical industry, it is often used as a key intermediate in organic synthesis. Due to its unique molecular structure, it can be converted into a variety of compounds with specific properties through a series of chemical reactions, such as some highly effective drugs, high-performance dyes and unique additives.
In the field of drug development, this is used as a starting material. After ingenious chemical modification and synthesis steps, it is expected to prepare drugs with special pharmacological activities. The benzothiazole ring and nitro, methyl and other substituents in its structure can participate in the interaction with biological targets, or regulate the metabolic pathway of drugs, and then play a therapeutic effect.
In the dye industry, 2-methyl-6-nitro-1,3-benzothiazole can be used as an important cornerstone for the synthesis of new dyes. Its structure endows the synthesized dyes with unique color characteristics and stability, which can meet the requirements of textile, printing and other industries for color richness and durability of dyes.
In addition, in terms of material additives, compounds derived from them can be used as additives for plastics, rubber and other materials, improving the anti-oxidation and anti-aging properties of materials, and enhancing the service life and application value of materials.
In short, 2-methyl-6-nitro-1,3-benzothiazole plays an indispensable role in many fields due to its unique chemical structure, promoting the development and progress of related industries.

2-Methyl-6-nitro-1,3-benzothiazole is one of the organic compounds. Its physical properties are well-researched.
Looking at its appearance, under room temperature and pressure, it is mostly in the shape of a solid state, either a powder or a crystal. The color state varies depending on the preparation method and purity, and it often shows a light yellow to light brown color.
When it comes to the melting point, the melting point of this compound is quite critical, about [X] ° C. This value varies slightly depending on the specific purity and measurement conditions. The determination of the melting point is an important indicator when identifying and purifying the substance.
As for the boiling point, under specific pressure conditions, the boiling point is about [X] ° C. The boiling point reflects the energy required for its transformation from liquid to gaseous state, and this property is crucial in separation and purification processes such as distillation.
In terms of solubility, 2-methyl-6-nitro-1,3-benzothiazole exhibits a specific tendency to dissolve in organic solvents. It has a certain solubility in organic solvents such as ethanol and acetone, but little solubility in water. This difference in solubility provides an important basis for its separation, purification and choice of reaction medium.
Density is also one end of its physical properties. Although the specific value will vary slightly depending on the measurement environment, its density is about [X] g/cm ³. The density is of great significance in terms of the relationship between the mass and volume of the substance, as well as the distribution in the mixed system.
In addition, this compound may have a specific odor. Although the description of the odor of your mileage may vary, many people feel that its odor is special and can be distinguished from others in the sense of smell.
From the above, it can be seen that the physical properties of 2-methyl-6-nitro-1,3-benzothiazole are complex and diverse, and the properties are interrelated. They are of great value in many fields such as chemical research and industrial applications, and can help researchers and practitioners better understand and use the substance rationally.

2-Methyl-6-nitro-1,3-benzothiazole, this is an organic compound. Its chemical properties are unique, containing the basic structure of benzothiazole, and methyl and nitro groups are connected at specific positions.
Let's talk about the physical properties first. Under normal circumstances, it may be a solid. Due to the Van der Waals force between molecules, it has a certain melting point and boiling point. However, the exact value needs to be accurately determined by experiments.
Besides chemical properties, methyl has a electron-giving effect, and nitro has an electron-withdrawing effect. The electron-giving effect of methyl may increase the electron cloud density of the benzene ring, which in turn makes the benzene ring more prone to electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. The strong electron-absorbing properties of the nitro group can reduce the electron cloud density of the benzene ring, making it more difficult for the electrophilic substitution reaction to occur in the ortho-para-position of the nitro group, but making the meta-position relatively easier to react. Moreover, these two substituents will also affect the electron cloud distribution of the benzothiazole ring, change the charge density of each atom on the ring, and affect its chemical reactivity.
Furthermore, the benzothiazole ring in this compound itself has a certain aromaticity, giving it a certain stability. However, due to the introduction of methyl and nitro groups, the aromaticity may be slightly changed. In addition, in case of strong oxidants, nitro groups may be further oxidized; while methyl groups may undergo oxidation and halogenation reactions under specific conditions.
From the perspective of reactivity, due to the presence of nitro groups, the distribution of molecular electron clouds is uneven, some atoms are partially positively charged, and some are partially negatively charged, making it easy to react with reagents with opposite charges.
In short, the chemical properties of 2-methyl-6-nitro-1,3-benzothiazole are determined by their structure, and each group affects each other, resulting in unique chemical activities and reaction characteristics.

There are various methods for the synthesis of 2-methyl-6-nitro-1,3-benzothiazole. Although the ancient book "Tiangong Kaiwu" does not describe the synthesis method of this compound in detail, the principles of its creation can enlighten our thinking for the synthesis method.
In today's chemical synthesis path, one of the first is to use o-aminophenol as the starting material, through acylation reaction, the amino group is protected to form the corresponding amide derivative. This amide derivative is introduced into the nitro group at a specific position in the benzene ring under the action of a suitable nitrifying agent, such as a mixed acid of concentrated nitric acid and concentrated sulfuric acid. Subsequent to the hydrolysis reaction, the protective group is removed, and then the cyclization reaction promotes the formation of intramolecular rings to generate 2-methyl-6-nitro-1,3-benzothiazole.
Second, 2-methylbenzothiazole is used as the starting material and directly nitrified with a nitrifying reagent. However, it should be noted that this reaction requires precise control of the reaction conditions. Due to the activity and localization effect of the benzothiazole ring, the nitro introduction position may be different under different conditions. It is necessary to adjust the temperature, concentration and ratio of nitrifying reagents and other factors to selectively introduce nitro into the 6-position to obtain the target product.
Third, the benzothiazole ring can also be constructed from the perspective of constructing the benzothiazole ring. Under basic conditions, the benzothiazole ring can be constructed by a series of reactions such as nucleophilic substitution and cyclization with suitable o-halogenated anilines and sulfur-containing compounds, such as thioamides. During the reaction process, methyl groups can be introduced first, and then nitro groups can be introduced in suitable steps, or vice versa. Depending on the specific reaction conditions and feasibility, the reaction route can be carefully designed to achieve the purpose of synthesizing 2-methyl-6-nitro-1,3-benzothiazole.

2-Methyl-6-nitro-1,3-benzothiazole is in the market, and its price range is difficult to determine. This compound is quite specialized in use, and may be useful in chemical and pharmaceutical research and development. However, its price is also often changed due to multiple reasons.
First, the price of the raw material can be the main reason. If the materials used in the synthesis of this benzothiazole have floating prices, the price of this compound will be affected by it. If the raw material is dilute, and there are many people who want it, the price will be high; if the raw material is abundant, the supply exceeds the demand, and the price may drop.
Second, the preparation technique is also related to its price. If the technique is simple and efficient, the amount of production is large, the cost may drop, and the price will follow; if the technique is complicated and the consumption is huge, the production is limited, and the price will be high.
Third, the supply and demand of the city is particularly critical. If there are many users, the demand is greater than the supply, and the price will rise; if no one asks, the supply exceeds the demand, and the price will be suppressed.
Fourth, the origin, quality, etc., can also make the price different. Produced in different places, the price may vary depending on the distance and tax; those with excellent quality will always be higher than the crude product.
However, based on today's market conditions, it is difficult to determine the exact price without detailed examination. Or a hundred yuan per gram, or a few yuan per gram, it is possible. If you want to know the details, you must visit various suppliers and observe changes in the market before you can get a near-real price.