2-methyl-4-(trifluoromethyl)-5-aminothiazole

2-Methyl-4- (trifluoromethyl) -5-aminothiazole, this is an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of pharmaceutical synthesis. The creation of many drugs relies on it as a base, through a series of chemical reactions, adding different functional groups to obtain molecules with specific pharmacological activities. For example, in the development of antibacterial drugs, with its unique structure, it fits with specific bacterial targets to achieve antibacterial effect.
In the field of pesticides, 2-methyl-4- (trifluoromethyl) -5-aminothiazole is also indispensable. Using it as a starting material, high-efficiency insecticides and fungicides can be prepared. Such pesticides can precisely act on the physiological processes of pests or pathogens, inhibit their growth and reproduction, protect crops from damage, and improve yield and quality.
In addition, in the field of materials science, this compound may participate in the synthesis of functional materials. Because it contains special functional groups, it gives the material unique electrical, optical or chemical properties. For example, in the preparation of organic photovoltaic materials, it is cleverly designed to polymerize with other monomers, so that the material has excellent photoelectric conversion performance, which is conducive to the development of solar cells and other fields.

The synthesis method of 2-methyl-4- (trifluoromethyl) -5-aminothiazole, although the ancient book "Tiangong Kaiwu" does not contain this substance, it can be described with a similar chemical synthesis idea.
To synthesize this compound, one method can be started with a sulfur-containing compound and a nitrogen-containing reagent. First, take an appropriate halogenated hydrocarbon, such as 2-methyl-4- (trifluoromethyl) -halogenated ethyl ketone, and react with thiourea in a suitable solvent. Usually an alcohol solvent is preferred, such as ethanol, heated to a certain temperature, about 60-80 degrees Celsius. Under this condition, the halogen atom of halogenated ethyl ketone undergoes nucleophilic substitution reaction with the sulfur atom of thiourea, and the prototype of thiazole ring is initially formed.
Then, the obtained intermediate product is modified by amination. Ammonifying reagents, such as liquid ammonia or ammonia gas, can be used to introduce into the reaction system. In the presence of catalysts, such as complexes of metal catalysts such as palladium and platinum, under a certain pressure and temperature environment, the pressure is about 1-3 atmospheres, and the temperature is 80-120 degrees Celsius, which prompts the amino group to replace the group at the corresponding position to obtain 2-methyl-4- (trifluoromethyl) -5-aminothiazole.
Another way is to construct the parent structure of the thiazole ring first, and react with thiamide with carboxylic acid derivatives containing methyl and trifluoromethyl. In an alkaline environment, such as potassium carbonate and sodium carbonate in basic solutions, in organic solvents such as dichloromethane or toluene, the carboxylic group of the carboxylic acid derivative is condensed with the amino group of the thioamide to form a thiazole ring. Then through suitable reduction amination means, such as sodium borohydride-nickel chloride reduction system, the carbonyl group at a specific position is converted into an amino group, and the final target product is 2-methyl-4- (trifluoromethyl) -5-aminothiazole. Both methods require fine control of the reaction conditions to obtain a product with higher yield and purity.

2-Methyl-4- (trifluoromethyl) -5-aminothiazole is one of the organic compounds. Its physical and chemical properties are quite important, and it is of key significance in many fields such as chemical industry and medicine.
Looking at its physical properties, under normal temperature and pressure, this compound is mostly in a solid state, but it also varies depending on its purity and crystallization. The determination of its melting point is one of the important indicators for identifying the properties of the substance. Generally speaking, a clear range of melting points helps to identify its purity and crystal form. If impurities are mixed, the melting point often decreases and the melting range becomes wider. After many experiments, its melting point is roughly in a certain range, but the exact value depends on the specific experimental conditions and test methods.
Furthermore, its solubility is also a key physical property. In common organic solvents, such as ethanol, acetone, dichloromethane, etc., this compound exhibits different degrees of solubility. In polar organic solvents, its solubility may be more significant. This is because the molecular structure contains polar groups, which can form strong interactions with polar solvents, such as hydrogen bonds, dipole-dipole interactions, etc. In non-polar solvents, the solubility is relatively poor.
In terms of its chemical properties, the amino group and thiazole ring give this compound unique reactivity. The amino group is a nucleophilic group and can participate in many nucleophilic substitution reactions. For example, when it encounters halogenated hydrocarbons, the amino group can attack the carbon atoms of halogenated hydrocarbons, undergo nucleophilic substitution, and form new nitrogen-containing derivatives. The thiazole ring is also non-idle, and the electron cloud distribution on its ring is special, which can participate in the aromatic electrophilic substitution reaction under specific conditions. At the same time, due to the strong electron-absorbing effect of trifluoromethyl, the electron cloud density of the thiazole ring decreases, which in turn affects its reactivity and selectivity. In redox reactions, this compound also exhibits certain characteristics, which can act as an oxidizing agent or a reducing agent according to the reaction conditions, participating in various redox conversion processes, and is extremely valuable in the design of organic synthesis routes.

2-Methyl-4- (trifluoromethyl) -5-aminothiazole, this product is in the market, and its price is difficult to determine. Its price is influenced by many factors, such as the complexity of the process, the price of raw materials, the situation of supply and demand, and even the differences in time and place.
Looking at the past, if the preparation method is simple, and the raw materials are easy to obtain and cheap, the price may be easy. However, if the preparation requires exquisite techniques, and the raw materials are rare, the price will be high. As for the supply and demand end, if there are many people and there are few suppliers, the price will rise; on the contrary, if the supply exceeds the demand, the price may fall.
In addition, the price varies depending on the region. In prosperous places, commerce is prosperous, logistics is convenient, or because of competition, the price may be reasonable; while in remote places, transportation is difficult, costs increase, and the price may be higher. And the migration of times, the rise and fall of the economy, and the change of policies can all make this price move.
In the current situation, the exact price is not available in the city. If you want to know the details, you should consult the merchant of chemical materials, or check the platform of chemical trading carefully to get a more accurate price range.

2-Methyl-4- (trifluoromethyl) -5-aminothiazole is an important organic compound, which is widely used in the fields of medicine, pesticides and so on. Many chemical companies and scientific research institutions are involved in the production and research of this compound.
In China, such as Shanghai's ** Shanghai search banner biochemical technology joint stock company **, which focuses on the research and development, production and sales of scientific research reagents. The products provided cover various organic compounds, 2-methyl-4- (trifluoromethyl) -5-aminothiazole or in its product directory. Furthermore, ** Jiangsu Qiangsheng Functional Chemistry joint stock company **, has considerable strength in the production of organic intermediates, and may also produce this compound. With its advanced production process and strict quality control, it provides high-quality products for the market.
There are also many manufacturers abroad. For example, ** Sigma - Aldrich Company **, as a world-renowned chemical reagent supplier, its product line is extremely rich, 2-methyl-4- (trifluoromethyl) - 5-aminothiazole or its regular supply products, known for its high quality and high purity, and is favored by scientific researchers and enterprises. Another example is ** TCI (Tokyo Chemical Industry Co., Ltd.) **, which has a good reputation in the production and sales of organic synthesis reagents. It may also provide this compound. The products are known for their stable quality and complete range.
However, due to the dynamic changes in the chemical industry, new manufacturers may continue to emerge, and old manufacturers may adjust their production direction. For accurate and up-to-date manufacturer information, you can consult chemical product catalogs, industry reports, or consult chemical industry experts.