2-mercapto-4-methyl-thiazole acetic acid

2-% hydroxyl-4-methylvaleric acid is an organic compound with important uses in various fields.
In the field of medicine, it is a key intermediate for drug synthesis. For example, in the preparation of specific antibiotics, 2-hydroxy- 4-methylvaleric acid can build the core structure of antibiotics through a series of chemical reactions, providing an important starting material for the development of antibacterial drugs, helping to improve the efficacy of drugs and expand the antibacterial spectrum. This intermediate is also involved in the synthesis of some drugs for the treatment of cardiovascular diseases, which is of great significance for regulating blood lipids and stabilizing cardiovascular function.
In the chemical industry, it can participate in the synthesis of special performance polymer materials. By polymerizing with other monomers, the material is endowed with unique physical and chemical properties. For example, synthetic polyester materials, due to the introduction of 2-hydroxy- 4-methylvaleric acid structure, have better flexibility and corrosion resistance, and are widely used in packaging materials, engineering plastics and other fields. In addition, in the coating industry, polymers containing this structure can improve the adhesion and durability of coatings and prolong the service life of coatings.
In the field of food and fragrances, 2-hydroxy- 4-methylvaleric acid is also used. Because of its special smell and flavor, it can be used as a food additive after proper preparation, enhancing the aroma and taste of food, and enriching the flavor level of food. In the synthesis of fragrances, it can be used as an important raw material to prepare a unique aroma, which can be used in perfumes, air fresheners and other products to improve the aroma quality
In biochemical research, it is an important tool for studying biological metabolic pathways. Due to its participation in specific metabolic processes in organisms, scientists can deeply understand the metabolic laws of substances in organisms by studying their metabolic transformation, providing theoretical basis for revealing the essence of life activities, disease mechanisms and drug targets.

2-% pentyl-4-methyl-hexenedioic acid is an organic compound. Its physical properties are complex and detailed as follows:
- ** Properties **: Under normal conditions, this substance is mostly crystalline solid, with a fine texture and a pure white appearance, like the first snow in winter, highlighting the regular and orderly chemical structure of its chemical structure and the tight arrangement of molecules.
- ** Melting point **: About [X] ° C, at this specific temperature, the lattice can reach a balance with the thermal motion energy of the molecule, the solid lattice disintegrates, and the molecule can be freed from bondage and start a free-flowing journey, from the solid state to the liquid state elegantly. < Br > - ** Boiling point **: about [X] ℃, when the temperature rises to this point, the molecular thermal movement is extremely intense, enough to overcome the attractive force between molecules, break free from the liquid phase limitation, and turn into gas phase dissipation, achieving the transition of gas-liquid equilibrium.
- ** Solubility **: In organic solvents, such as ethanol, ether, etc., it shows good solubility, just like the fusion of fish and water. This is due to the similarities between its molecular structure and organic solvents. Following the principle of "similar miscibility", the intermolecular force makes the two miscible. However, the solubility in water is poor. Due to the dominance of hydrophobic groups, it is difficult to form an effective force between water molecules and solute molecules, limiting their dispersion in water. < Br > - ** Density **: About [X] g/cm ³, this value reflects the degree of tight packing of molecules. The density is related to the molecular mass and the distance between molecules, reflecting the microstructural characteristics of the substance. In the gravitational field, this density determines its floating state in a specific liquid medium.
- ** Stability **: Under conventional conditions, the substance has a certain stability, the molecular structure is relatively stable, and it is not easy to spontaneously undergo chemical reactions. However, in extreme environments such as high temperature, strong acid, and strong alkali, the chemical structure may be damaged, triggering chemical reactions such as acidification and alkalinolysis, which change the original composition and structure of the molecule.

The chemical properties of 2-% hydroxyben4-methyl-pentenedioic acid are quite stable. In this compound, the structure of hydroxybenzene and methyl makes it have unique chemical stability.
Its stability is derived from the interaction between atoms in the molecular structure. The hydroxybenzene at the 2 position forms a stable bond with neighboring atoms, forming a relatively stable local structure. In a chemical reaction environment, although this hydroxybenzene has certain activity, it is difficult to easily participate in the reaction due to the constraints of the overall structure of the molecule.
Furthermore, the methyl group at the 4 position contributes significantly to the overall stability by adding the molecular structure. The presence of methyl groups changes the distribution of the electron cloud of the molecule and enhances the interaction force inside the molecule, making the overall structure more compact and stable.
The core structure of pentylenedioic acid is also stabilized to a certain extent due to the influence of the above hydroxyl group and methyl group. This stabilizing effect makes the double bond less susceptible to attack by external reagents and reduces the possibility of addition reactions.
Under common chemical environments, 2-% hydroxyben4-methyl-pentylenedioic acid can withstand many mild conditions without significant chemical changes. That is, in the general acid-base environment, without special catalysts or strong reaction conditions, the chemical structure of this compound remains relatively intact and its chemical properties are as stable as before.
The stability of this compound is of great significance in many fields. In organic synthesis, it can be used as a stable structural unit to provide a reliable basis for the construction of complex organic molecules. In the field of materials science, its stability may confer specific performance advantages on materials, such as chemical resistance.

To prepare 2-hydroxy- 4-methyl-pentenoic acid, there are three methods.
First, ethyl acetoacetate is used as the beginning, and it is first co-heated with aluminum isopropoxide and acetone, and then clayson condensation is carried out to obtain β-ketoate. After hydrolysis with dilute alkali solution, followed by acid treatment, and then heating decarboxylation, the target product can be obtained. This process is delicate, the active methylene in ethyl acetoacetate, in an alkaline environment, attacks the nucleophilic carbonyl of acetone, forms a new carbon-carbon bond, hydrolyzes and decarboxylates, and finally obtains 2-hydroxy- 4-methyl-pentenoic acid. < Br >
Second, based on diethyl malonate, first react with halogenated hydrocarbons to introduce the desired hydrocarbon group. The halogenated hydrocarbons need to contain the corresponding carbon chain fragments in the target structure. Then basic hydrolysis, then acidification and decarboxylation. The methylene of the diethyl malonate, due to the influence of dicarbonyl, has high activity and is easy to be nucleophilic substituted with halogenated hydrocarbons, followed by hydrolysis and decarboxylation, which can lead to the formation of products.
Third, with suitable aldose and ketone as materials, it is condensed by hydroxyaldehyde. If the formaldehyde and ketone with suitable carbon frame are selected, under the catalysis of dilute alkali, the α-hydrogen of the aldehyde and the carbonyl of the ketone are condensed to form β-hydroxyaldehyde or ketone, and then dehydrated to obtain unsaturated carbonyl compounds. After proper oxidation, the carbonyl group is converted to carboxyl, and 2-hydroxy- 4-methyl-pentenoic acid can be obtained. This reaction uses hydroxyaldehyde condensation to build carbon chains, oxidize and adjust functional groups, and achieve the purpose of synthesis.
All synthesis methods have their own advantages and disadvantages, and they need to be carefully selected according to the availability of raw materials, the difficulty of reaction conditions, and the requirements of product purity.

The price range of 2-% hydroxy-4-methyl-pentenedioic acid in the market is quite relevant, and it is difficult to determine the exact number.
This compound has a wide range of uses and is useful in the fields of medicine and chemical industry. Its preparation methods are also diverse, and the choice of raw materials and the difference in process can cause changes in cost, which in turn affects its market price.
If it is taken by ancient methods, the process is or complex, the materials used are or luxury, and the price is high. If new technologies make the preparation easy and the cost is reduced, the price is low. In addition, the supply and demand of the market is also a major factor. If there are many people who want it, the price will increase; if there is an oversupply, the price will decrease.
And the difference in the purity of this compound is also the difference in price. Those with high purity are difficult to prepare, and the price must be higher than those with low purity.
According to the current situation, if it is of ordinary purity, its price may be in the range of hundreds of yuan per kilogram. If it is of high purity, it should be in the range of thousands of yuan per kilogram, or even higher. However, the market situation is changeable, and the price fluctuation is also unpredictable. The price of chemical raw materials often changes due to changes in the price of raw materials, easier policies, and advances in science and technology. Therefore, if you want to know the exact price, you should look at the real-time market conditions and consult the industry and merchants to obtain a near-real number.