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What is the chemical structure of 2- (Dimethylaminomethyl) -4- (2-aminoethylthiomethyl) thiazole
The chemical structure of 2 - (dimethylaminomethyl) - 4 - (2 - aminoethylthiomethyl) thiazole is quite wonderful. Looking at its structure, the thiazole ring is the backbone, this ring has a five-element shape, and is co-structured by sulfur, nitrogen two atoms and three carbon atoms, showing a unique planar ring shape.
At the second position of the thiazole ring, there is a dimethylaminomethyl group. In this group, the nitrogen atom of the amino group is connected with two methyl groups, and then the methylene group is connected to the thiazole ring. The electronic properties of the methyl group may affect the electron cloud distribution of the thiazole ring.
As for the fourth position, it is connected to the 2-aminoethyl thiomethyl group. Among them, the sulfur atom is a bridge, connecting the thiazole ring with the 2-aminoethyl group. In the case of 2-aminoethyl, the one end of the ethyl group is connected to the amino group. This amino group has the characteristics of a power supplier, or affects the chemical activity and reactivity of the whole molecule. The existence of sulfur atoms, because of its lone pair of electrons, may make the spatial structure of the molecule and the distribution of electron clouds more complex.
Such a structure makes the compound have unique performance in chemical reactions, biological activities, etc., which is worthy of further investigation in chemical research.
What are the physical properties of 2- (Dimethylaminomethyl) -4- (2-aminoethylthiomethyl) thiazole
2-%28Dimethylaminomethyl%29-4-%282-aminoethylthiomethyl%29thiazole, this is an organic compound. Looking at its structure, it contains a thiazole ring, the second position of the ring is connected to dimethylaminomethyl, and the fourth position is connected to 2-aminoethylthiomethyl.
In terms of its physical properties, it is usually in a solid state or a liquid state at room temperature and pressure. If it is a solid state, it is mostly crystalline and has a fine texture. Its melting point varies depending on the intermolecular force, but it is roughly within a certain range.
In terms of solubility, due to the fact that there are both polar groups containing nitrogen and sulfur in the molecule, as well as non-polar parts such as alkyl groups, it may have a certain solubility in organic solvents, such as ethanol, acetone, etc. Due to the principle of similar phase dissolution, polar organic solvents interact with the polar parts of compounds to help them dissolve. In water, because of its non-extreme polarity, solubility may be limited.
In appearance, pure substances may be colorless to slightly yellow. If they contain impurities, the color may change. Its smell, or the smell of special organic compounds, however, the description of the specific smell needs to be sensed by the pro-smell, and your mileage may vary. The density of
may be similar to that of compounds with similar structures, depending on their relative molecular weights and molecular stacking methods. In chemical reactions, the groups in its structure endow it with various reactive activities, or participate in various reactions such as nucleophilic substitution and electrophilic addition, which have potential uses in the field of organic synthesis.
What are the common uses of 2- (Dimethylaminomethyl) -4- (2-aminoethylthiomethyl) thiazole?
2-%28Dimethylaminomethyl%29-4-%282-aminoethylthiomethyl%29thiazole is 2 - (dimethylaminomethyl) -4 - (2 - aminoethylthiomethyl) thiazole, which is an organic compound. Its common uses involve the field of medical chemistry.
In pharmaceutical research and development, such compounds containing thiazole structures often have unique biological activities. The special structure of the Geiin thiazole ring gives it the possibility to interact with specific targets in vivo. Or it can be used as a potential drug lead compound, modified by organic synthesis to improve the affinity and selectivity to specific disease-related targets, so as to develop new drugs for the treatment of diseases such as inflammation and tumors.
Or used as a tool compound in biochemical research. Through its specific action with biological macromolecules, researchers can help explore biochemical reaction mechanisms and signal transduction pathways in organisms. For example, by binding to specific enzymes or receptors, study the function of the enzyme or receptor and related regulatory mechanisms.
Furthermore, in the field of pesticide chemistry, such compounds may also have potential application value. Or can be developed as new pesticides, with their special chemical structure and biological activity, they can inhibit or kill pests, pathogens, etc. Compared with traditional pesticides, they may have advantages such as environmental friendliness, low toxicity and high efficiency.
In summary, 2 - (dimethylaminomethyl) -4 - (2 - aminoethylthiomethyl) thiazoline has a unique structure and has important potential uses in many fields such as medicine, biochemistry, and pesticide chemistry. It provides many opportunities for the development of scientific research and related industries.
What are the synthesis methods of 2- (Dimethylaminomethyl) -4- (2-aminoethylthiomethyl) thiazole
To prepare 2 - (dimethylaminomethyl) - 4 - (2 - aminoethylthiomethyl) thiazole, there are many methods, which are described in detail today.
First, start with the compound containing thiazole, and add dimethylaminomethyl and 2 - aminoethylthiomethyl through substitution reaction. First, take an appropriate thiazole parent, add a base to a suitable solvent to activate it, and then drop in the halogenated hydrocarbon containing dimethylaminomethyl, control the temperature and duration, so that the substitution is smooth. After this step is completed, another reagent containing 2-aminoethylthiomethyl is prepared, such as the intermediate obtained by the reaction of 2-halogenated ethyl sulfide with ammonia, and then reacts with the previous product. After a series of operations, such as extraction, distillation, recrystallization, etc., the target product is obtained.
Second, start with the construction of a thiazole ring. Select raw materials containing sulfur, nitrogen and suitable carbon chains, such as β-halogenated ketone and thiourea to form a thiazole ring first, and adjust the pH and temperature during the reaction to make the cyclization better. After the cyclization, dimethyl amino methyl and 2-aminoethylthiomethyl are added by the previous method by substitution reaction. In the process, each step of the reaction requires fine control conditions, and the purity and dosage of the reagents used are carefully checked, otherwise the yield and purity will be affected.
Third, use metal catalysis. Select an appropriate metal catalyst, such as palladium, copper, etc., to promote the reaction. Halogenated thiazole derivatives are used as raw materials to react with nucleophiles containing dimethylaminomethyl and 2-aminoethylthiomethyl under metal catalysis. Among these, the ligand selection of the metal catalyst is important, and different ligands affect the reaction activity and selectivity. And the anaerobic and anhydrous environment of the reaction system is also critical to prevent the metal catalyst from deactivation. After many attempts and optimizations, temperature, pressure and reaction time were controlled to make each step accurate, and finally 2 - (dimethylaminomethyl) -4 - (2-aminoethylthiomethyl) thiazole was prepared.
2- (Dimethylaminomethyl) -4- (2-aminoethylthiomethyl) thiazole during use
2-%28Dimethylaminomethyl%29-4-%282-aminoethylthiomethyl%29thiazole, it is a chemical substance. During use, many precautions need to be paid attention to.
Bear the brunt, and safety protection is of paramount importance. This substance may be toxic and irritating, touching the skin, eyes, or inhaling its dust and vapor, can cause injury. Therefore, when operating, be sure to wear appropriate protective equipment, such as protective gloves, protective glasses, gas masks, etc., to prevent contact with the human body. If accidentally touched, rinse with plenty of water immediately, and seek medical treatment according to specific conditions.
Secondly, storage should not be underestimated. Store it in a cool, dry, well-ventilated place, away from fire and heat sources. Due to its chemical properties or instability, it may be exposed to heat, open flames, etc., or cause dangerous reactions. At the same time, it should be stored separately from oxidants, acids, etc., and must not be mixed to prevent chemical reactions.
Furthermore, the use process should strictly follow the operating procedures. The dosage should be precisely controlled, and it should not be increased or decreased at will, so as not to affect the experimental results or cause safety accidents. And the operating environment should be well ventilated to prevent the accumulation of its vapor. After use, properly dispose of the remaining substances and waste, and do not discard them at will. It needs to be treated harmlessly in accordance with relevant regulations.
In addition, users should also have a deep understanding of its properties and reaction characteristics. Know its reaction under different conditions in order to deal with possible emergencies. Only by paying full attention to the above precautions can we ensure the safety and efficiency in the use of 2-%28Dimethylaminomethyl%29-4-%282-aminoethylthiomethyl%29thiazole.