2-(chloromethyl)-1,3-thiazole-4-carboxylate

2-%28chloromethyl%29-1%2C3-thiazole-4-carboxylate is 2- (chloromethyl) -1,3-thiazole-4-carboxylic acid ester, which has a wide range of uses. In the field of medicinal chemistry, it can be used as a key intermediate to help synthesize drug molecules with specific biological activities. Due to the properties of thiazole ring and chloromethyl in its structure, it can interact with specific targets in organisms, so it plays an important role in the creation process of many antibacterial, anti-inflammatory and anti-tumor drugs.
In the field of pesticide chemistry, 2- (chloromethyl) -1,3-thiazole-4-carboxylic acid esters are also of important value. It can be used to prepare new pesticides, and by virtue of its unique chemical structure, it can inhibit or kill pests and bacteria, providing a new way for agricultural pest control. For example, by reasonably modifying the structure of the compound, its toxicity and selectivity to specific pests can be enhanced, and then high-efficiency and low-toxicity green pesticides can be developed.
Furthermore, in the field of organic synthesis, 2- (chloromethyl) -1,3-thiazole-4-carboxylic acid esters, as intermediates with high reactivity, can participate in a variety of organic reactions, such as nucleophilic substitution, cyclization, etc. Through these reactions, more complex and diverse organic compounds can be constructed, providing rich raw materials and methods for the development of organic synthetic chemistry. In conclusion, 2 - (chloromethyl) - 1,3 - thiazole - 4 - carboxylic acid esters play a significant role in many fields and are of great significance to promoting the development of related fields.

To prepare 2 - (chloromethyl) - 1,3 - thiazole - 4 - carboxylic acid ester, there are various methods. First, start with 4 - carboxylic acid - 1,3 - thiazole, and undergo chloromethylation. In this case, polyformaldehyde and hydrogen chloride are used as agents in a suitable solvent, such as dichloromethane, for temperature control reaction. Polyformaldehyde is depolymerized to produce formaldehyde, which reacts with the 4 - carboxylic acid group of thiazole, and hydrogen chloride is supplied with chlorine to form chloromethylation.
Second, thiazole derivatives containing suitable substituents are used as groups. A group that can be converted to chloromethyl, such as hydroxymethyl, is first introduced into the thiazole ring, and then a chlorinating agent, such as dichlorosulfoxide, is used to convert the hydroxymethyl to chloromethyl. The reaction of dichlorosulfoxide with hydroxymethyl, through the process of substitution, obtains chloromethyl compounds, and at the same time generates sulfur dioxide and hydrogen chloride gas to escape.
Third, starting from thiazole-4-carboxylate, the reaction is halogenated. N-chlorosuccinimide (NCS) is used as a halogenating agent, and in the presence of an initiator, such as benzoyl peroxide, the reaction is induced by light or heat. NCS supplies chlorine radicals to capture hydrogen at a specific position on the thiazole ring to form 2- (chloromethyl) -1,3-thiazole-4-carboxylic acid esters.
Each method has its advantages and disadvantages, and it needs to be selected according to the availability of raw materials, the difficulty of reaction, the yield and the convenience of subsequent treatment.

2-%28chloromethyl%29-1%2C3-thiazole-4-carboxylate is an organic compound, and its physicochemical properties are quite important, which is related to many chemical and industrial applications.
The appearance of this compound is often white to light yellow crystalline powder, because its molecular structure has specific atoms and functional groups arranged, resulting in this shape. In terms of melting point, it is about in a specific temperature range, and the specific value varies due to factors such as purity, but it is roughly between [X] ℃ - [X] ℃. This melting point characteristic is of great significance in the separation, purification and identification of compounds, and its purity and authenticity can be judged by melting point measurement.
In terms of solubility, 2-%28chloromethyl%29-1%2C3-thiazole-4-carboxylate show certain solubility characteristics in organic solvents. In polar organic solvents such as ethanol and acetone, it has moderate solubility and can form a uniform solution. Due to the interaction between molecules and solvent molecules, such as hydrogen bonds and van der Waals forces, etc. In water, the solubility is relatively limited, because the polarity of the molecular structure and the matching degree of water molecules are not perfect.
Chemical stability is also a key property. 2-%28chloromethyl%29-1%2C3-thiazole-4-carboxylate chemical bonds within the molecule give it a certain stability, it can exist stably at room temperature and pressure in a dry and dark environment. When encountering specific chemical reagents, such as strong oxidants, strong bases or strong acids, chemical reactions will occur. In case of strong bases, the ester groups in the molecule are easily hydrolyzed to form corresponding acids and alcohols; in case of strong oxidants, some groups in the molecule may be oxidized, changing the chemical structure and properties.
In addition, its spectral properties are also worthy of attention. In infrared spectroscopy, due to the vibration of specific functional groups, there are absorption peaks at specific wavenumbers, which can be used for structure identification. In nuclear magnetic resonance spectroscopy, hydrogen atoms or carbon atoms at different positions will generate characteristic signals, which help to determine the connection mode and chemical environment of atoms in the molecule.
The above physical and chemical properties play a decisive role in the application of 2-%28chloromethyl%29-1%2C3-thiazole-4-carboxylate in organic synthesis, drug development and other fields.

I look at your question, but I am inquiring about the price range of 2- (chloromethyl) -1,3-thiazole-4-carboxylate in the market. However, the price of this product often changes for many reasons, and it is difficult to determine a certain number.
First, the price of raw materials has a great impact. If the raw materials required for the synthesis of this salt, such as chloromethyl and thiazole, their prices fluctuate with the supply and demand of the market. If the price of raw materials is high, the price of finished products will also be high; if the price of raw materials decreases, the price of finished products may also decrease.
Second, the complexity of the preparation process is related to the cost. The process is complex, requires exquisite equipment, many steps, energy consumption and manpower are also large, the cost will be high, and its price will be high; if the process is simple and efficient, the cost will be reduced, and the price will also be low.
Third, the market supply and demand trend determines the price. Those who ask for it are numerous, and those who supply it are few, the price will go up; if the supply exceeds the demand, the price will fall.
Fourth, the product purity specifications also have an impact. Those with high purity and strict specifications will have a higher price than ordinary ones.
As far as I know, this product is in the market, and the price may be between tens of yuan and hundreds of yuan per kilogram. However, this is only a rough estimate, not an exact number. If you want to know the exact price, you should consult chemical raw material suppliers, traders, or check in detail on the chemical product trading platform to obtain the actual price.

2-%28chloromethyl%29-1%2C3-thiazole-4-carboxylate is an important organic compound. Its storage conditions are crucial to the stability and quality of the compound.
This compound should be stored in a cool, dry and well-ventilated place. A cool environment can reduce the risk of decomposition or deterioration due to excessive temperature. High temperatures often accelerate chemical reactions and damage the structure of compounds, so maintaining low temperatures is crucial.
Dry conditions are also indispensable. Moisture in the air can react with the compound or cause it to hydrolyze, which in turn affects its chemical properties and purity. Therefore, it is necessary to ensure that the humidity in the storage area is low, and a dry environment can be maintained by auxiliary means such as desiccants.
Furthermore, good ventilation can disperse harmful gases that may be generated in time, and can avoid potential dangers caused by excessive local concentrations.
At the same time, when storing this compound, it should be kept away from fire sources, oxidants and other substances that may cause danger. Fire sources can easily cause compounds to burn or even explode, while oxidants may undergo violent oxidation reactions with them, changing their chemical composition and properties.
In addition, the choice of storage containers cannot be ignored. Appropriate materials should be selected to ensure that they do not react with compounds and have good sealing to prevent compound leakage and invasion of external substances.
Proper storage 2-%28chloromethyl%29-1%2C3-thiazole-4-carboxylate requires comprehensive consideration of temperature, humidity, ventilation and storage containers to ensure that the stability and quality of the compound during storage are not affected.