2-Bromothiazole-4-carboxylic acid ethyl ester

2-Bromothiazole-ethyl 4-carboxylate has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. The unique structure of the thiazole ring endows compounds with diverse biological activities, so it is often used to create new drugs in medicinal chemistry. For example, in the research and development of antibacterial drugs, by modifying and modifying its structure, it is expected to obtain new drugs with excellent antibacterial properties.
In the field of pesticide chemistry, 2-bromothiazole-4-carboxylate ethyl ester also has important applications. After specific reaction transformation, pesticides with high insecticidal, bactericidal or herbicidal effects can be prepared, making great contributions to agricultural pest control.
In addition, it is also involved in the field of materials science. Using it as a raw material, materials with special properties can be synthesized through a series of reactions, such as materials with excellent optical properties and electrical properties, to meet the specific needs of electronic devices, optical instruments and other fields.
This compound plays a key role in many fields due to its own structural properties, and has become an indispensable part of organic synthetic chemistry. It is of great significance for promoting the development of industries such as medicine, pesticides, and materials.

The synthesis method of 2-bromothiazole-4-carboxylic acid ethyl ester is of interest in the field of organic synthesis. There are many synthesis paths, and the common methods are described in detail below.
First, thiazole-4-carboxylic acid ethyl ester is used as the starting material, and the target product can be obtained by bromination reaction. In this reaction, bromine or N-bromosuccinimide (NBS) are often used as the bromination reagent. If bromine is used, bromine is usually added dropwise to the solution of thiazole-4-carboxylic acid ethyl ester in appropriate solvents such as dichloromethane and chloroform under low temperature conditions. When using NBS, it is generally necessary to add an initiator, such as benzoyl peroxide, to initiate the reaction under heat or light conditions. This reaction condition is relatively mild and has good selectivity, which can reduce the occurrence of side reactions.
Second, start from 2-halothiazole. Prepare 2-halothiazole first, and then react with the corresponding carboxylic acid ester derivatives. For example, the halides of 2-chlorothiazole and 4-carboxylic acid ethyl ester under the action of base, generate 2-bromothiazole-4-carboxylic acid ethyl ester by nucleophilic substitution reaction. Commonly used bases include potassium carbonate, sodium carbonate, etc. Polar aprotic solvents such as N, N-dimethylformamide (DMF) and dimethyl sulfoxide (DMSO) can be selected as reaction solvents, which are conducive to improving the reaction rate and yield.
Third, the construction of thiazole ring is taken as the initial step. The thiazole ring is constructed by reacting compounds containing sulfur and nitrogen atoms with suitable halogenated carboxylic acid esters. For example, thiourea and halogenated acetoacetate ethyl ester are used as raw materials to cyclize to form thiazole derivatives under acidic or basic conditions, and then brominated to obtain 2-bromothiazole-4-carboxylate ethyl ester. This method has a little more steps, but the synthesis strategy can be flexibly adjusted according to the availability of raw materials and the control of reaction conditions.
Each synthesis method has its own advantages and disadvantages. In practical applications, the most suitable synthesis path should be selected according to the comprehensive consideration of many factors such as raw material cost, reaction conditions, purity and yield of target products.

What you are asking about is the market price of ethyl 2-bromothiazole-4-carboxylate. However, these prices often vary depending on time, place, quality and supply and demand.
In the past, the price of this chemical may have been higher due to the difficulty of synthesis and the high cost of raw materials. If its synthesis requires complex processes, and the raw materials are rare, the price will be high. However, if science and technology advance, the synthesis method is simple, and the raw materials are easily available, the price may drop.
In addition, market supply and demand are also key. If there are many people who need it, and there are few producers, the price will rise; conversely, if there is more production and less demand, the price will be depressed.
And in different places, the price is also different. Convenient transportation and the prosperity of the chemical industry, due to the convenience of transportation and the benefit of industrial agglomeration, the price may be relatively easy; while in remote places, due to the difficulty of transportation, the cost increases, and the price may be high.
Furthermore, the quality also affects the price. Those with high purity and excellent quality must have higher prices than ordinary ones.
However, I cannot determine the exact market price at the moment. Since the market is changing rapidly, if you want to know the accurate price, you should consult the chemical raw material market merchants, chemical trading platforms, or industry experts to obtain the latest and accurate price information.

Ethyl 2-bromothiazole-4-carboxylate is an important intermediate in organic synthesis. It has unique physical and chemical properties and is widely used in many fields.
Looking at its physical properties, under normal conditions, this compound is mostly solid, and its color may be white to light yellow. Its melting point, boiling point and other properties are caused by the interaction of atoms and chemical bonds in the molecular structure. At the melting point, the intermolecular force is overcome, and the substance changes from solid to liquid; at the boiling point, the molecule obtains enough energy to escape from the liquid state into a gaseous state. The exact melting point and boiling point values are affected by the purity of the compound and the test conditions, and need to be accurately determined by experiments.
In terms of chemical properties, bromine atoms are highly active in ethyl 2-bromothiazole-4-carboxylate. Bromine atoms are electron-absorbing, which makes them prone to nucleophilic substitution reactions. Nucleophilic agents can attack bromine atoms to connect to carbon atoms, and bromine ions leave to form new compounds. In this process, the properties of nucleophilic reagents and reaction conditions such as temperature and solvent have significant effects on the reaction rate and product selectivity.
In addition, ester groups in molecules also have specific chemical activities. Under acidic or basic conditions, ester groups can undergo hydrolysis reactions. In acidic hydrolysis, 2-bromothiazole-4-carboxylic acid and ethanol are formed; in basic hydrolysis, carboxylate and ethanol are produced. This hydrolysis reaction is often used in organic synthesis to construct new compounds or modify molecular structures.
The presence of thiazole ring endows molecules with certain aromaticity and stability, which affects their chemical activity and reaction selectivity. Under specific conditions, thiazole ring can participate in various reactions, such as electrophilic substitution with electrophilic reagents, providing more possibilities for organic synthesis.
In summary, the physical and chemical properties of 2-bromothiazole-4-carboxylic acid ethyl ester lay the foundation for its application in organic synthesis, medicinal chemistry and other fields. By understanding and mastering its properties, researchers can design and implement efficient and selective organic synthesis routes to create more valuable compounds.

Ethyl 2-bromothiazole-4-carboxylate is an organic compound. When storing and transporting, many things need to be paid attention to.
First, the storage environment is very important. It should be placed in a cool, dry and well-ventilated place to avoid direct sunlight and high temperature. Because of its certain heat sensitivity, under high temperature, it may cause decomposition, deterioration, damage quality and performance. If stored in a humid environment, or reacts with water vapor, the product will be affected.
Second, it should be kept away from fire, heat and oxidants. This compound may be flammable, and in case of open flame or hot topic, it may cause combustion. And the oxidant comes into contact with it, or induces severe chemical reactions, which brings potential safety hazards.
Third, ensure that the packaging is well sealed when storing. Prevent the intrusion of impurities such as air and moisture, which will affect the purity and stability of the product. After taking it, the packaging should also be sealed in time to avoid deterioration due to long-term exposure to air.
Fourth, the packaging must be stable during transportation. Use suitable packaging materials to prevent damage to the container and material leakage due to collision and vibration. And the transportation vehicle should be equipped with corresponding fire equipment and emergency treatment equipment to deal with emergencies.
Fifth, handle it with care when handling, and do not load and unload brutally. Avoid danger due to strong impact, friction, etc. Those who handle and come into contact with this compound need to have corresponding protective knowledge and measures, such as wearing protective gloves, goggles, etc., to prevent harm to the human body.
In summary, proper storage and safe transportation of 2-bromothiazole-4-ethyl carboxylate is of great significance to ensure its quality, performance, and personnel and environmental safety.