2-Bromo-6-fluoro-1,3-benzothiazole

2-Bromo-6-fluoro-1,3-benzothiazole is one of the organic compounds. It has a wide range of uses and is often a key intermediate in the field of medicinal chemistry. In terms of creating new drugs, its structure is unique and can be combined with other molecules through chemical reactions to derive substances with specific biological activities. It can be used to develop drugs for the treatment of various diseases, such as anti-cancer, antibacterial and other drugs.
In the field of materials science, it also has important functions. Due to its special chemical structure, it imparts different properties to materials. For example, it can be used to prepare materials with special optical and electrical properties. In the preparation of organic optoelectronic materials, the addition of this compound may optimize the luminous efficiency and electron transport properties of the material, which can be used in the manufacture of organic Light Emitting Diodes (OLEDs), solar cells and other devices.
In the field of pesticide chemistry, 2-bromo-6-fluoro-1,3-benzothiazole may also play a role. After modification and transformation, it may become an active ingredient of pesticides with high efficiency and low toxicity, showing inhibitory or killing effects on specific pests and bacteria, assisting agricultural pest control and ensuring crop yield and quality.
Overall, 2-bromo-6-fluoro-1,3-benzothiazole has important uses in many fields, providing a key material basis for the development of related industries. As research progresses, its potential uses may be further expanded.

2-Bromo-6-fluoro-1,3-benzothiazole is an organic compound with unique physical properties, which are described as follows:
- ** Appearance properties **: Under normal temperature and pressure, this compound is mostly in solid form, but the appearance may vary slightly due to differences in purity and preparation conditions. If the purity is very high, or it is a white to light yellow crystalline powder, the texture is uniform and delicate, and it may have a certain luster under light.
- ** Melting boiling point **: The melting point is a key parameter for measuring its physical state transformation. After measurement experiments, its melting point is in a specific temperature range, which varies slightly due to experimental conditions and measurement methods. Generally speaking, the melting point is about [X] ° C. At this temperature, the compound gradually melts from the solid state to the liquid state, the intermolecular forces change, and the lattice structure disintegrates. The boiling point is related to the temperature at which it changes from the liquid state to the gas state. The boiling point of 2-bromo-6-fluoro-1,3-benzothiazole is about [Y] ° C. At this temperature, the molecule obtains enough energy to overcome the liquid surface tension and the intermolecular attractive forces and escape into the gas phase.
- ** Solubility **: In organic solvents, its solubility varies. In common organic solvents such as dichloromethane and chloroform, it can exhibit good solubility and can form appropriate forces with solvent molecules, such as van der Waals force, hydrogen bonds, etc., and then disperse uniformly to form a uniform solution. In water, due to its poor molecular polarity and water matching, its solubility is poor, only slightly soluble or almost insoluble. This property is closely related to the influence of hydrophobic groups in the molecular structure.
- ** Density **: Density is also one of the important physical properties, and its value reflects the mass of the substance per unit volume. The density of 2-bromo-6-fluoro-1,3-benzothiazole is approximately [Z] g/cm ³. This value indicates its relative relationship to the mass of other substances at the same volume, which is important for chemical operations and engineering applications involving mass and volume conversion.
- ** Spectral Properties **: In the infrared spectrum, the vibration of specific chemical bonds produces characteristic absorption peaks. For example, the C-H stretching vibration of the benzene ring at the wavenumber of about 3000-3100 cm ¬ or the current absorption peak, and the C = S double bond vibration at the wavenumber of about 1200-1300 cm ¬ also produces characteristic absorption, which can be used for structure identification. In nuclear magnetic resonance spectroscopy, hydrogen and carbon atoms in different chemical environments will peak at specific chemical shifts, providing a strong basis for molecular structure analysis.

To prepare 2-bromo-6-fluoro-1,3-benzothiazole, the following method can be followed.
First take a suitable starting material, such as an aniline derivative containing the corresponding substituent. Take 6-fluoro-2-aminothiophenol as an example, this is the key starting material. React it with a suitable brominating agent, such as liquid bromine or N-bromosuccinimide (NBS), in a suitable reaction solvent. If liquid bromine is used, liquid bromine can be slowly added dropwise in an inert solvent such as dichloromethane at low temperature. This is because the reactivity of bromine is high, the reaction rate is controlled at low temperature, and excessive bromination is prevented. The reaction needs to be closely monitored. Thin-layer chromatography (TLC) can be used to observe the ratio of raw materials to products. When the raw materials are almost exhausted, the reaction is stopped.
If N-bromosuccinimide is used, because the reaction is relatively mild, it can be reacted in solvents such as carbon tetrachloride under the condition of heating and refluxing. NBS will gradually release bromine free radicals and replace with specific positions of the phenyl ring in aminothiophenol. Due to its localization effect, bromine atoms can be introduced mainly at the ortho-position of the amino group to obtain key intermediates.
Subsequently, the obtained intermediate is reacted with a suitable cyclization reagent. Sulphosgene or carbon disulfide can often be selected for cyclization under alkali catalysis. If sulfur phosgene is used, the solution of the intermediate can be slowly added dropwise to the mixture of alkali (such as triethylamine) and sulfur phosgene at low temperature. The alkali can neutralize the acid formed by the reaction, promote the reaction to proceed forward, and undergo intramolecular cyclization to obtain 2-bromo-6-fluoro-1,3-benzothiazole.
After the reaction is completed, a post-treatment process is required. By extraction, the product is extracted from the reaction mixture with an organic solvent such as ethyl acetate, etc., and then washed with water, dried, etc., to remove impurities. Finally, the product is purified by column chromatography or recrystallization, and pure 2-bromo-6-fluoro-1,3-benzothiazole can be obtained.

I don't know the price range of 2-bromo-6-fluoro-1,3-benzothiazole in the market. The price of this unusual and well-known product may vary greatly due to changes in quality, purity, supply and demand. If you want to know the price, you can go to the market where chemical raw materials are traded, and the website where chemical products are sold, and consult the merchant to get the exact number. The price of chemical products fluctuates frequently, and it varies with market conditions, the amount of raw materials, and the difficulty of production. Or you can find the reason for chemical products in books such as "Tiangong Kaiwu", but the price of this specific product may not be detailed in them. In order to obtain the price of 2-bromo-6-fluoro-1,3-benzothiazole, it is appropriate to investigate and ask in detail in the current chemical trade field and network platform.

2-Bromo-6-fluoro-1,3-benzothiazole is a kind of organic compound. Its storage conditions are crucial and related to the stability and quality of this compound.
To properly store this compound, the first environment is dry. Moisture can easily cause many chemical reactions, which damage the structure and purity of the compound. Therefore, when choosing a dry place, if it is indoors, a desiccant can be placed next to the storage container to absorb the surrounding moisture.
The second is temperature control. Generally speaking, it should be stored in a cool place to avoid high temperature. High temperature can accelerate the reaction and cause the compound to deteriorate. Generally, it is better to be 2-8 ° C. It can be placed in the refrigerator freezer. However, it is necessary to pay attention to sealing to avoid interaction with other substances in the refrigerator.
Furthermore, light is also the key. This compound may be sensitive to light, and light may cause it to decompose or undergo photochemical reactions. Therefore, the storage container should be light-shielding, such as a brown glass bottle, and should be placed in a dark place to avoid direct sunlight and strong light.
In addition, the storage place should be well ventilated. Avoid the accumulation of gas emitted by the compound to prevent safety hazards and maintain its stability.
During storage, the sealing of the container should not be ignored. If the seal is not tight, air, moisture, etc. can easily invade and destroy the compound. High-quality sealed containers should be used to ensure that there is no risk of leakage.
In general, the storage of 2-bromo-6-fluoro-1,3-benzothiazole needs to take into account dry, cool, shading, ventilation and sealing conditions, so as to ensure that the material can maintain good quality and chemical properties for a long time.