2-Bromo-1,3-thiazole-4-carboxylic acid

2-Bromo-1,3-thiazole-4-carboxylic acid, this is an organic compound. Looking at its physical properties, it is mostly in a solid state under normal temperature and pressure. Due to the strong interaction forces between molecules, such as hydrogen bonds, van der Waals forces, etc., it exists in a solid state.
When it comes to melting point, due to the interaction between atoms and functional groups in the molecular structure, at a specific temperature, the molecule obtains enough energy to overcome the lattice energy, causing the lattice structure to disintegrate, and then has a fixed melting point. Sadly, I do not have the exact melting point value.
As for solubility, there are polar carboxyl groups and bromine and thiazole ring parts in the molecule. The carboxyl group is hydrophilic, but the thiazole ring and the bromine atom have certain hydrophobicity. Therefore, the solubility in water is limited, and the hydrophobicity partially prevents it from fully interacting with water molecules. However, in polar organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), due to the principle of similar miscibility, or good solubility, it can form hydrogen bonds or other interactions with solvent molecules to dissolve.
Looking at its appearance, it is usually white to off-white powder or crystalline solid. This is due to the orderly arrangement of molecules and the reflection characteristics of light, resulting in the appearance of such colors and shapes. Its density is also closely related to the molecular structure. The type, number and arrangement of atoms jointly determine its density, but the exact value is unknown.
In summary, the physical properties of 2-bromo-1,3-thiazole-4-carboxylic acids are influenced by the interaction between functional groups and atoms in the molecular structure, and exhibit corresponding characteristics under different conditions.

2-Bromo-1,3-thiazole-4-carboxylic acid, this is an organic compound. It is acidic and contains a carboxyl group (-COOH). Under suitable conditions, the carboxyl group can release protons, exhibit the characteristics of an acid, and can neutralize with bases to generate corresponding salts and water.
Its bromine atom also gives the compound unique reactivity. Bromine atoms are relatively active and can participate in many substitution reactions. For example, in nucleophilic substitution reactions, nucleophiles can attack carbon atoms attached to bromine, replace bromine atoms, and then derive new compounds with different structures.
The structure of the thiazole ring also has an important impact on the properties of this compound. The thiazole ring, as a heterocyclic ring containing nitrogen and sulfur, imparts certain stability and special electronic effects to the molecule. This electronic effect affects the reactivity of other substituents on the ring, and also makes the compound unique in some biological activities and chemical reactions.
In addition, 2-bromo-1,3-thiazole-4-carboxylic acids may have certain solubility. The existence of carboxyl groups makes it soluble in polar solvents (such as water, alcohols, etc.), but the hydrophobicity of thiazole rings and bromine atoms will limit their solubility. < Br >
Due to its multi-activity check point in the structure, it can be used in the field of organic synthesis to provide basic raw materials for the construction of more complex organic molecules.

2-Bromo-1,3-thiazole-4-carboxylic acid, the common synthesis method is as follows:
The starting material can be selected from a compound containing a thiazole ring, and the bromine atom and carboxyl group are introduced through a specific reaction. One of the common ones is to use 4-methyl-1,3-thiazole as the starting material. The bromination reaction of 4-methyl-1,3-thiazole is first carried out, which can be used in a suitable solvent, such as carbon tetrachloride, in the presence of light or initiator, and interact with the bromine elemental substance. In this reaction, the hydrogen atom on the methyl group is replaced by the bromine atom to generate 4-bromomethyl-1,3-thiazole.
Then, 4-bromo-1,3-thiazole is oxidized to introduce carboxyl groups. It is often reacted with strong oxidants, such as potassium permanganate, under basic conditions. During the reaction, bromo-methyl is oxidized to carboxyl groups, and after subsequent acidification treatment, 2-bromo-1,3-thiazole-4-carboxylic acid can be obtained.
Another method uses 4-aldehyde-1,3-thiazole as raw material. The aldehyde group is first brominated, and in a suitable reaction system, such as in the mixture of pyridine and bromine, the hydrogen atom at the ortho-position of the aldehyde group is replaced by bromine to generate 2-bromo-4-aldehyde-1,3-thiazole. Subsequently, the aldehyde group is oxidized, and a suitable oxidizing agent, such as Jones reagent, can be used to oxidize the aldehyde group to a carboxyl group to obtain 2-bromo-1,3-thiazole-4-carboxylic acid.
Or, starting from the raw material containing sulfur and nitrogen heterocycles, a thiazole ring is constructed through a multi-step reaction, and bromine atoms and carboxyl groups are introduced at the same time. If thioacetamide and α-bromopyruvate are used as raw materials, the cyclization reaction under basic conditions will form a thiazole ring, and the product has bromine atoms and ester groups. After hydrolysis of ester groups, the target product 2-bromo-1,3-thiazole-4-carboxylic acid can be obtained after acidification.

2-Bromo-1,3-thiazole-4-carboxylic acid, this substance has a wide range of uses. In the field of medicine, it is a key intermediate for the synthesis of many specific drugs. For example, some antibacterial drugs can build unique chemical structures, enhance antibacterial activity, and fight stubborn bacteria. For example, in the development of anti-cancer drugs, its structural properties help to precisely act on cancer cells, inhibit the growth and spread of cancer cells, and bring new hope for cancer treatment.
In the field of pesticides, it also plays an important role. It can be used to create new insecticides. With its unique chemical properties, it has high-efficiency contact and stomach toxicity against pests, and is relatively friendly to the environment. It can effectively protect crops from insect infestation and improve crop yield and quality.
In the field of materials science, 2-bromo-1,3-thiazole-4-carboxylic acids can participate in the synthesis of special functional materials. For example, it is used to prepare materials with specific optical or electrical properties. It shows potential application value in optoelectronic devices, such as Light Emitting Diodes, solar cells, etc., driving the continuous development of materials science and opening up more innovative applications.

I don't know the market price of 2 - Bromo - 1,3 - thiazole - 4 - carboxylic acid. This is a chemical substance, and its price often varies for a variety of reasons.
First, the cost of preparing this compound is the key factor. The price of raw materials may vary depending on the place of origin, season, and supply and demand. If raw materials are scarce or difficult to extract, the cost will be high, and the price of the product will also rise. The instruments and reagents used in the preparation process, as well as the manpower and energy required, will affect the cost, which in turn will affect the market price.
Second, the relationship between supply and demand in the market is also crucial. If there is strong demand for 2-Bromo-1,3-thiazole-4-carboxylic acid in many industries, such as pharmaceuticals, chemicals, and other fields, it will be used for the research and development and manufacturing of specific products, but the supply is limited, and the price will rise easily. On the contrary, if the demand is low, and the manufacturers produce too much, the supply will exceed the demand, and the price may decline.
Third, the quality of this compound produced by different manufacturers is different, which will also lead to price differences. High-quality products have higher prices due to fine purification, few impurities, or are more favored by the market.
Fourth, regional factors cannot be ignored. The price of this compound may vary in different places due to differences in transportation costs, tax policies, and local economic levels. For those who are transported from afar, the transportation cost is added to it, and the price may be higher than that of local production.
In summary, to know the exact market price of 2 - Bromo - 1,3 - thiazole - 4 - carboxylic acid, it is necessary to carefully investigate the cost of raw materials, supply and demand, quality, region and many other factors, and it is advisable to inquire from chemical product trading platforms, suppliers and other channels to obtain more accurate price information.