2-Benzothiazolecarboxylic acid, ethyl ester

2-%E8%8B%AF%E5%B9%B6%E5%99%BB%E5%94%91%E7%BE%A7%E9%85%B8%E4%B9%99%E9%85%AF%E7%9A%84%E4%B8%BB%E8%A6%81%E7%94%A8%E9%80%94%E4%B8%89%E7%A7%8D%EF%BC%8C%E4%B8%80%E4%B8%BA%E5%8C%BB%E7%96%97%E7%94%A8%E9%80%94%EF%BC%8C%E4%BA%8C%E4%B8%BA%E5%88%B6%E8%8D%AF%E7%94%A8%E9%80%94%EF%BC%8C%E4%B8%89%E4%B8%BA%E5%85%B6%E4%BB%96%E5%B7%A5%E4%B8%9A%E7%94%A8%E9%80%94%E3%80%82
** First, medical use **
This medicine is used for medical purposes and has outstanding efficacy. It can regulate human qi and blood, and has curative effect on many diseases. For example, it can be used to relieve pain in the human body, whether it is due to the invasion of wind cold and dampness, resulting in blocked meridians, poor qi and blood caused by limb pain; or viscera disorders, internal pain caused by qi and blood stasis, can be relieved. And it also has the function of regulating the viscera of the human body, which can help the spleen and stomach transport and transformation, enhance the source of qi and blood biochemistry, make the human body have sufficient qi, and resist the invasion of external evils. Such as weakness of the spleen and stomach, loss of appetite, fatigue and other diseases, rational use can be improved. In addition, it can also play an important role in the conditioning of some chronic diseases, helping patients gradually recover and improve the quality of life.
** Second, pharmaceutical use **

In the pharmaceutical field, 2-%E8%8B%AF%E5%B9%B6%E5%99%BB%E5%94%91%E7%BE%A7%E9%85%B8%E4%B9%99%E9%85%AF is an important raw material. Because of its unique chemical properties and pharmacological activities, it can be refined, processed, and made into drugs in various dosage forms. Pills, powders, ointments, etc. can be prepared according to their characteristics and formula requirements. During the pharmaceutical process, according to different diseases and treatment needs, the dosage is precisely prepared in combination with other medicinal materials to achieve the best therapeutic effect. The resulting drugs are not only easy to store and take, but also can exert their therapeutic effects more accurately. They are widely used in various pharmaceutical formulations and are relied on by the pharmaceutical industry. < Br >
** III. OTHER INDUSTRIAL USES **
In addition to medical and pharmaceutical uses, it is also used in other industrial fields. In the perfume industry, because of its unique odor, after special treatment, it can be used as an additive to perfume, adding a unique flavor to the fragrance and enhancing the quality and uniqueness of the fragrance. In the manufacturing process of some chemical products, because of its certain chemical stability and reactivity, it can participate in some chemical reactions and be used as an auxiliary raw material to optimize the performance of chemical products. For example, in the production of certain coatings, adhesives and other products, adding an appropriate amount of this substance can improve the adhesion, durability and other properties of the product, and broaden its application range in industrial production.

2-%E8%8B%AF%E5%B9%B6%E5%99%BB%E5%94%91%E7%BE%A7%E9%85%B8%E4%B9%99%E9%85%AF%E7%9A%84%E7%89%A9%E7%90%86%E6%80%A7%E8%B4%A8%E5%A6%82%E4%B8%8B%E6%89%80%E8%BF%B0:
In terms of solubility, it is usually a white crystalline powder with a stinky smell and a slightly bitter taste. Its melting properties are characteristic, and it usually melts at a certain degree of melting. This degree of melting is one of its important physical properties and can be used to determine this.
In terms of solubility, it is slightly soluble in water, soluble in ethanol, and insoluble in trichloromethane or ether. This poor solubility also means that its molecules are closely related to each other. Due to the specific distribution of molecular characteristics, it exhibits different solubility tables in different solubilities.
In addition, the characterization of this property is also worth noting. In normal and dry conditions, this property is determined, but if exposed to poor components such as moisture, high temperature or light, it may be biochemically transformed and affect its effectiveness. This is because some of the molecules are prone to cracking or rearrangement under the action of specific external factors.
Furthermore, its density is also a certain value. This physical property is not directly observed in normal use or has not been directly observed. However, the precise determination of density is important in the field of material quality, quantity control and phase research. In particular, the multi-physicality of 2-%E8%8B%AF%E5%B9%B6%E5%99%BB%E5%94%91%E7%BE%A7%E9%85%B8%E4%B9%99%E9%85%AF plays an indispensable and important role in its performance, use, preservation and research.

2-%E8%8B%AF%E5%B9%B6%E5%99%BB%E5%94%91%E7%BE%A7%E9%85%B8%E4%B9%99%E9%85%AF%E7%9A%84%E5%8C%96%E5%AD%A6%E6%80%A7%E8%B4%A8%E5%A6%82%E4%B8%8B%E6%89%80%E8%BF%B0:
This substance has unique physical and chemical properties. Looking at its properties, under room temperature, it is often colorless and transparent, and it is a viscous liquid, just like jade dew, pure and clear.
In terms of its solubility, in water, it can be miscible in any ratio, just like water emulsion, without blockage. This is because its molecular structure contains special groups, which are in harmony with water molecules, so it can be so.
The boiling point is quite high, about [X] ° C, just like the integrity of a gentleman, stick to it. This high boiling point is due to the strong force between molecules, so that molecules need to absorb a lot of energy to break free and turn into gaseous states.
As for its chemical activity, it is quite lively. Under suitable conditions, it can react with many substances. When encountering acid, it is like a warrior facing the enemy, and it can show unique chemical changes. If co-placed with strong acid, a specific substitution reaction can occur, and some groups in the molecular structure will be replaced by specific ions in the acid, resulting in a new compound, just like a phoenix nirvana, rejuvenating.
When encountering alkali, it is not inferior. It can neutralize and react with bases. Acids and bases interact to recombine atoms to form salts and other products, like yin and yang, reaching a new balance.
And in the field of organic synthesis, 2-%E8%8B%AF%E5%B9%B6%E5%99%BB%E5%94%91%E7%BE%A7%E9%85%B8%E4%B9%99%E9%85%AF is like a magical key that can open the door to the synthesis of many complex organic compounds. Because of its unique structure and reactivity, it can be used as a key intermediate to help synthesize various organic molecules with special functions and uses, contributing to the development of organic chemistry, just like a weapon in the hands of skilled craftsmen, carving out exquisite chemical treasures.

2-%E8%8B%AF%E5%B9%B6%E5%99%BB%E5%94%91%E7%BE%A7%E9%85%B8%E4%B9%99%E9%85%AF%E7%9A%84%E5%90%88%E6%88%90%E6%96%B9%E6%B3%95%E6%9C%89%E4%B8%8B%E5%88%97%E4%B8%89%E7%A7%8D%EF%BC%9A
** 1. Take 2-naphthol as the starting material **
Pure 2-naphthol and place it in a clean reactor. Take an appropriate amount of dimethyl sulfate as the methylating reagent, and slowly add dimethyl sulfate in a mild alkaline environment. The reaction system needs to maintain a suitable temperature, about 40-60 degrees Celsius, and at the same time add moderate stirring to fully contact the reactants. The alkaline environment can be created by an aqueous solution of sodium carbonate or potassium carbonate, and the concentration should be precisely regulated.
When reacting, pay close attention to the reaction process, which can be monitored in real time by thin layer chromatography. After the reaction is completed, the product is extracted with an organic solvent such as ether or ethyl acetate. After the extract is dried with anhydrous sodium sulfate, the solvent is removed to obtain a crude product. Purified 2-methoxynaphthalene can be obtained by column chromatography or recrystallization.
Then, 2-methoxynaphthalene and an appropriate amount of acetyl chloride, anhydrous aluminum trichloride as a catalyst, in an inert solvent such as dichloromethane, are carried out at low temperature. The reaction temperature should be controlled at 0-10 degrees Celsius, and attention should be paid to isolating water vapor during the reaction. After the reaction is completed, the reaction mixture is hydrolyzed with dilute hydrochloric acid, the organic phase is separated, washed with water, dried, and the solvent is removed to obtain 2-methoxy-6-acetylnaphthalene.
Finally, under suitable reaction conditions, 2-methoxy-6-acetylnaphthalene is demethylated, and hydrobromic acid or boron tribromide is used as demethylation reagent. The reaction in a specific solvent can obtain 2-hydroxy-6-acetylnaphthalene, that is, an important intermediate of 2-naphthalene pyrone-6-ethyl acetate. The target product can be prepared by subsequent esterification and other reactions. < Br >
** Second, using 2-naphthoic acid as the starting material **
First, 2-naphthoic acid and ethanol are esterified under the catalysis of concentrated sulfuric acid under heating and reflux to obtain 2-naphthoic acid ethyl ester. During the reaction, the water generated by the reaction is removed by a water separator to promote the reaction to proceed in the positive direction. After the reaction is sufficient, the reaction solution is cooled, washed with saturated sodium carbonate solution, the sulfuric acid and unreacted 2-naphthoic acid are removed, and then dried with anhydrous magnesium sulfate, and the corresponding fractions are distilled to obtain pure 2-naphthoate ethyl ester.
Subsequently, the condensation reaction of 2-ethyl naphthalate and ethyl acetoacetate in an inert solvent is carried out under the action of an alkaline catalyst such as sodium alcohol. The reaction temperature is controlled in an appropriate range, such as 60-80 degrees Celsius. After the reaction is completed, the product is acidified to precipitate. After separation, washing and drying, an intermediate containing a specific functional group is obtained.
Finally, through a series of reaction steps such as reduction and cyclization, the structure of the target product 2-naphthalene pyrone-6-ethyl acetate is gradually constructed. In this process, the reaction conditions of each step need to be carefully controlled to ensure the selectivity and yield of the reaction. < Br >
** III. Using 2-naphthyl acetone as the starting material **
2-naphthyl acetone and diethyl carbonate are catalyzed by sodium ethyl alcohol. The reaction temperature is maintained near the reflux temperature of ethanol. After a period of reaction, the reaction mixture is cooled and acidified with dilute hydrochloric acid to free the generated product. After extraction, drying, concentration, etc., the corresponding β-ketoate intermediate is obtained.
Next, the intermediate is hydrolyzed and decarboxylated under acidic conditions, and the reaction temperature and time are controlled to promote its conversion into specific unsaturated ketones. 2-Naphthopyrone-6-ethyl acetate was synthesized by esterification reaction with suitable alcohols under acid catalysis, and by some means such as catalytic hydrogenation, the unsaturated bonds were properly treated. The reaction conditions of each step of this route are related to each other and need to be carefully optimized to achieve the desired synthesis effect.

2-%E8%8B%AF%E5%B9%B6%E5%99%BB%E5%94%91%E7%BE%A7%E9%85%B8%E4%B9%99%E9%85%AF%E8%80%85, it is the process of hiding things, and it is necessary to be cautious and careful. Many things must be hidden, and it cannot be ignored.
The first word is that this compound should be stored in a good place. Its nature or susceptibility, the shadow of the tide, if it is high and the tide is in the environment, it is afraid of being damaged, and even dangerous. And it must be the source of fire, the source of fire, in order to prevent it from reacting because of it, and it will become a fire or explosion. The storage of water, also oxidizing, acid and other substances, because of its strong reaction, it is impossible to be born.
Furthermore, the container of storage is also studied. Use appropriate materials, good density, to prevent leakage. Containers of corrosion-resistant materials, such as special glass, plastic, or gold, are often used, depending on their characteristics. And on the container, the information of the name, sex, and danger warning of the item must be clearly displayed, so that people can easily use it and prevent it from being used.
Until the first time, the package must be kept in good condition and meet the requirements.
Before the first time, the package must be kept in good condition and meet the requirements.
If it is unfortunate that there is a leak, there must also be appropriate fire protection and leakage equipment. On the way, the driver must follow the traffic regulations, and pay attention to the damage of the goods, so as not to be subject to strong shocks and collisions. If the road is in a densely populated area, be more careful to prevent accidental leakage from endangering the people.
If it is unfortunate that there is a leak, it is necessary to take effective measures. It is necessary to prevent leakage, according to the amount of leakage, or use sand, vermiculite and other substances to cover the adsorption, or introduce the liquid treatment system. Incidents, polluted places, also clean the bottom to ensure the safety of the environment.
In this case, 2-%E8%8B%AF%E5%B9%B6%E5%99%BB%E5%94%91%E7%BE%A7%E9%85%B8%E4%B9%99%E9%85%AF%E in the place where it is hidden, and it is all safe, and there is no room for slack.