2-Amino Thiazole-5-Carboxylic Acid Ethyl Ester

Ethyl 2-amino-thiazole-5-carboxylate is an important chemical substance in the field of organic synthesis and has a wide range of uses.
In the field of medicinal chemistry, it is often used as a key intermediate. The construction of many drug molecules requires this as the starting material, and other functional groups are introduced through a series of chemical reactions to synthesize compounds with specific pharmacological activities. For example, in the development of antibacterial drugs, ethyl 2-amino-thiazole-5-carboxylate can be used as the basic structure to enhance the inhibition or killing ability of drugs against specific bacteria by modifying side chains, which is of great significance for promoting the development of antibacterial drugs.
In the field of pesticide chemistry, it also plays an important role. It can be used to synthesize a variety of pesticide ingredients, such as some new insecticides, fungicides, etc. By modifying and optimizing its structure, it can make it highly efficient, low toxic and environmentally friendly, help agricultural production resist pest attacks, and ensure crop yield and quality.
In dye chemistry, 2-amino-thiazole-5-carboxylate ethyl ester can participate in the synthesis of dyes with special colors and properties due to its unique structure. These dyes may have better light resistance, washing resistance and other excellent characteristics, and are widely used in textile, printing and dyeing industries to meet people's needs for color richness and durability of fabrics.
In summary, 2-amino-thiazole-5-carboxylic acid ethyl ester plays an important role in many fields such as medicine, pesticides and dyes, and has made significant contributions to the development of related industries.

The methods for preparing 2-aminothiazole-5-carboxylic acid ethyl ester have had their own advantages throughout the ages.
First, ethyl 2-bromopyruvate is used as the starting material. First, it reacts with thiourea in a suitable solvent, such as ethanol, under heated reflux conditions. During this process, the bromine atom of ethyl bromopyruvate undergoes nucleophilic substitution with thiourea, and then cyclization, resulting in 2-aminothiazole-5-carboxylic acid ethyl ester. This path step is still simple, but the raw material 2-ethyl bromopyruvate needs to be carefully prepared, and the reaction conditions need to be precisely controlled, otherwise the yield may be affected. < Br >
Second, starting from ethyl cyanoacetate. First, ethyl cyanoacetate is reacted with a vulcanizing reagent, such as phosphorus pentasulfide, in a suitable organic solvent such as toluene to achieve vulcanization to form ethyl cyanoacetate. Subsequently, it is reacted with haloacetamide under alkali catalysis, and the target product can also be obtained through the cyclization process. The raw materials of this method are relatively easy to obtain, but the vulcanization step requires slightly higher requirements for the reaction equipment, and phosphorus pentasulfide has an unpleasant odor. Caution is required during operation.
Third, ethyl acetoacetate is used as the starting material. It is first reacted with oxime to generate ethyl acetate oxime. After that, it reacts with carbon disulfide under alkaline conditions to form a sulfur-containing intermediate. Finally, 2-aminothiazole-5-carboxylic acid ethyl ester was prepared by cyclization, dehydration and other steps. There are relatively many steps in this path, but the reaction conditions of each step are relatively mild, the equipment requirements are not extremely strict, and it is easy to operate to a certain extent.
All these methods have advantages and disadvantages. It is necessary to carefully choose the appropriate synthesis path according to the actual situation, such as raw material availability, equipment conditions, cost considerations and other factors, before the efficient preparation of 2-aminothiazole-5-carboxylic acid ethyl ester.

2-Amino-thiazole-5-carboxylate ethyl ester, this is one of the organic compounds. Its physical and chemical properties are unique and worth exploring.
In terms of its physical properties, it is mostly solid at room temperature, and it is usually white to light yellow crystalline powder. As for the melting point, it is about [X] ° C, and this value may vary due to factors such as purity. The substance has limited solubility in water, but it can be soluble in some organic solvents, such as ethanol and dichloromethane. Because its molecular structure contains polar groups, it exhibits specific solubility characteristics between polar and non-polar solvents.
In terms of chemical properties, the amino group of 2-amino-thiazole-5-carboxylic acid ethyl ester is basic and can react with acids to form corresponding salts. The thiazole ring is the core structure of this compound and has certain aromaticity and stability. The ethyl carboxylate group has ester properties and can undergo hydrolysis reaction under acid or base catalysis. Hydrolysis in acidic medium can obtain 2-amino-thiazole-5-carboxylic acid and ethanol; hydrolysis under basic conditions is more thorough, and the products are corresponding carboxylate and ethanol. In addition, the compound can participate in a variety of organic synthesis reactions, such as substitution reactions with halogenated hydrocarbons. Under suitable conditions, amino or ester groups can be replaced by other functional groups, resulting in the derivation of many derivatives with different properties and uses. It is widely used in the field of organic synthesis.

I don't know what the price range of "2 - Amino + Thiazole - 5 - Carboxylic + Acid + Ethyl + Ester" is in the market. This is not a common thing I can see and know with my own eyes, and the market conditions are fickle, and the price is determined by various factors.
First, the supply and demand situation of this product has a great impact on its price. If there are many applicants and few suppliers, the price will rise; conversely, if the supply exceeds the demand, the price may fall.
Second, the quality of its quality is also related to the price. Those with high quality may be expensive; those with lower quality will be cheaper.
Third, the cost of producing this product is also the key. Such as the price of raw materials, production costs, human resources, etc., will all make the cost different, which in turn affects its market price.
Fourth, the difference in geography also plays a role in the price. Different places, due to transportation costs, market conditions, etc., the price may be different.
However, it is difficult to find the exact price range when I search all the books I can know. Or you need to consult the merchants specializing in such things, or the chemical products trading office, and the relevant industry information platform to get the approximate price range.

2-Amino-thiazole-5-carboxylate ethyl ester, this is an organic chemical substance. Its storage conditions are very critical, which is related to the stability and quality of this substance.
In the ancient meaning of "Tiangong Kaiwu", all materials need to be stored in a suitable storage place. 2-Amino-thiazole-5-carboxylate ethyl ester should be stored in a cool, dry and well-ventilated place. A cool place can avoid changes in its properties due to high temperature. If it is exposed to high temperature, it may cause chemical reactions to cause it to deteriorate. A dry environment is also indispensable. Moisture can easily make this substance damp, or react such as hydrolysis, which can damage its chemical structure.
Furthermore, keep away from fires, heat sources and oxidants. These chemicals are exposed to fire or heat sources, or risk combustion or even explosion. The oxidant can oxidize with 2-amino-thiazole-5-carboxylic acid ethyl ester, causing it to lose its original properties.
In addition, it should be sealed and stored when storing. Sealing can prevent air, moisture and other impurities from invading, and maintain its purity and stability.
When choosing a container, it is appropriate to use a corrosion-resistant material. Due to the reaction of 2-amino-thiazole-5-carboxylic acid ethyl ester or some materials, the container is damaged or the substance is contaminated. < Br >
Only when properly stored can 2-amino-thiazole-5-carboxylate still have good chemical properties for scientific research, production and other purposes.