2-Amino-thiazole-5-carbaldehyde

2-% hydroxy-pyrimidine-5-formaldehyde is an important intermediate in organic synthesis and has a wide range of uses in many fields. Although this specific compound is not directly mentioned in Tiangong Kaiwu, its use can be understood from the perspective of ancient applications of various substances and the development of chemical technology.
In the field of pharmaceutical chemistry, it can be used as a key raw material for the synthesis of many drugs. In the construction of many heterocyclic drug molecules with specific pharmacological activities, 2-% hydroxy-pyrimidine-5-formaldehyde participates in the reaction, which can introduce a unique pyrimidine ring structure, which plays a key role in the specific binding of drugs to targets, pharmacokinetic properties, etc., and helps to develop innovative drugs for the treatment of various diseases.
In the field of materials science, it can be used to prepare materials with special photoelectric properties. By reacting with other organic or inorganic compounds, a material system with specific structure and function is constructed, such as for organic Light Emitting Diode (OLED) materials to improve their luminous efficiency and stability; or as a sensor material for highly sensitive detection and identification of specific substances.
In the agricultural field, it can be used as an important intermediate for the synthesis of pesticides. On its basis, pesticide products with high insecticidal, bactericidal or herbicidal activities can be synthesized, which helps to ensure crop yield and quality, and resist pest and disease infestation.
In the fine chemical industry, it is an important starting material for the synthesis of a variety of fine chemicals. It can be used to synthesize special dyes, fragrances, etc., giving these products unique properties and qualities to meet the needs of different industrial and consumer markets. It is a crucial building block in the field of organic synthetic chemistry, providing the foundation for the construction of many complex organic compounds and promoting technological innovation and development in various related fields.

2-% hydroxy-pyrimidine-5-formaldehyde is a crucial intermediate in organic synthesis, and is widely used in many fields such as medicine, pesticides, and materials. Its synthesis methods are diverse, and the following are common:
1. ** Using 2-amino-5-bromopyrimidine as the starting material **:
- First, 2-amino-5-bromopyrimidine and sodium nitrite undergo diazotization in an acidic medium to form diazonium salts. This step requires precise control of the reaction temperature and pH to prevent the decomposition of diazonium salts.
- Diazonium salts are then reacted with formaldehyde under specific conditions, and subsequent steps such as hydrolysis can obtain 2-% hydroxy-pyrimidine-5-formaldehyde. There are relatively many reaction steps in this path, but the reaction conditions of each step are relatively mild, easy to control, and the yield is considerable.
2. ** Based on the construction of pyrimidine rings **:
- Select suitable carbonyl compounds and nitrogen-containing compounds, such as glyoxal and urea, and in the presence of a catalyst, undergo a cyclization reaction to form a pyrimidine ring. This process requires the selection of a high-efficiency catalyst to improve the reaction rate and selectivity.
- Hydroxylation and formylation of the resulting pyrimidine ring derivatives are carried out. Hydroxylation can introduce hydroxyl groups through nucleophilic substitution reaction, and formylation is commonly used in Wellsmeier-Hack reaction. Phosphorus oxychloride and dimethylformamide are used as reagents to react at appropriate temperatures to introduce formyl groups, and finally synthesize the target product. The starting materials of this method are common and easy to obtain, but the reaction process is relatively complicated, and the reaction conditions of each step need to be carefully regulated.
3. ** With the help of transition metal catalysis **:
- With halogenated pyrimidine derivatives as substrates, under the action of transition metal catalysts such as palladium catalysts, the coupling reaction occurs with formaldehyde sources. In this reaction, transition metal catalysts can effectively promote the formation of carbon-carbon bonds and carbon-heteroatomic bonds.
- At the same time, the addition of ligands can enhance the activity and selectivity of the catalyst. Reaction conditions such as temperature, solvent, and type of base have a great impact on the reaction and need to be carefully optimized. This method has high reaction efficiency and good selectivity, but the high cost of transition metal catalysts limits its large-scale application to a certain extent.

The physical properties of 2-% hydroxy-pentanal-5-methylsulfur are as follows:
This substance is a colorless to light yellow liquid at room temperature. It is clear and translucent in appearance, and there are no obvious impurities mixed in it. It has a unique smell, but it is not a pungent and unpleasant smell. It is a unique smell, which can be distinguished in specific scenes.
Its boiling point is within a certain range, at about [X] ° C. At this temperature, the substance gradually changes from liquid to gaseous. The characteristics of the boiling point make it possible to operate according to this temperature condition when separating, purifying and related chemical reactions. < Br >
The melting point is about [X] ° C. When the temperature drops to this point or below, the substance solidifies from liquid to solid, and the morphology changes. The value of the melting point is quite meaningful for the storage and transportation of the substance. The ambient temperature needs to be taken into account to prevent it from solidifying and affecting subsequent use.
The density is about [X] g/cm ³, which shows a specific specific gravity relationship compared with water. This density characteristic has a significant impact when it involves mixing, delamination, etc. If mixed with water, depending on the density difference, stratification may occur, which is helpful for separation by physical methods.
In terms of solubility, it can be dissolved in some organic solvents, such as ethanol, ether, etc. It also has a certain solubility in water, but the degree of solubility may be limited. This solubility characteristic is crucial for selecting a suitable solvent to realize the dispersion and reaction of substances in the fields of chemical production and drug preparation.
The vapor pressure of 2-% hydroxy-pentanal-5-methylsulfide also has a corresponding value at a specific temperature. The vapor pressure reflects the difficulty of volatilization. This property is related to the ventilation conditions of the storage environment. If the vapor pressure is high, more attention should be paid during storage to prevent its volatilization and dissipation.

In today's market, the price of diaminopyrimidine-5-formamide varies depending on various conditions.
The determination of its price is related to the supply and demand of raw materials. If the raw material is abundant and the supply is sufficient, its price may be flat; if the raw material is rare, difficult to harvest, and difficult to supply, the price will tend to rise. For example, if the raw material needs to be mined and transported far away, the road is long and the cost is large, and the cost will increase and the price will be high.
It is also related to the production method and technology. Sophisticated skills can make the production efficient and high-quality, and the cost can be reduced, so the price is also cheap. If the technique is clumsy and inefficient, the material loss is time-consuming, and the cost rises, the price will be high.
Competition in the market is also the main reason. If there are many competitors in the same industry, each will seek to sell well, or reduce its price to attract customers. If there are few competitors in the industry, it has the tendency to monopolize, and the price can often be high.
And the user's demand is also related to the price. In the fields of medicine, chemical industry, etc., if this material needs to be cut, the demand is prosperous but the supply is not enough, and the price will rise; if it is reduced, the supply will exceed the demand, and the price will decrease.
Overall, the market price of diaminopyrimidine-5-formamide, or fluctuating between tens of dollars and hundreds of dollars per catty, is difficult to determine. Only by carefully examining raw materials, production, competition, and demand can we obtain its approximate price.

Dihydroxyacetone, when storing and transporting, there are several things to pay attention to.
First of all, it is quite sensitive to temperature and humidity. This substance should be stored in a cool and dry place. If the temperature and humidity are inappropriate, it may cause changes in its properties. In case of hot and humid heat, when strictly checking the storage environment, if the temperature is too high, it may melt and decompose; if the humidity exceeds the limit, it is easy to absorb moisture and agglomerate, damaging its quality, so temperature control and humidity is a priority.
Second, dihydroxyacetone has a certain chemical activity. In the transportation and storage room, avoid mixing with strong oxidizing agents, strong acids and alkalis. Due to the presence of hydroxyl and carbonyl groups in its chemical structure, when it encounters a strong oxidizing agent, it is easy to oxidize and cause the components to deteriorate; when it encounters acid and alkali, it may cause a chemical reaction to change its chemical properties. This should not be careless.
Furthermore, whether the packaging is good or not is related to the safety of dihydroxyacetone. The packaging should be tightly sealed to prevent it from coming into contact with air and moisture. If the packaging is damaged, the intrusion of air and moisture will not only affect the purity, but also lead to the growth of microorganisms, resulting in product spoilage. Therefore, before shipment, the packaging must be checked carefully. If there is any damage, it should be replaced urgently.
When transporting again, vibration and collision should also be taken into account. Violent vibration, collision, or damage to the packaging, causing material leakage, and or due to external force, causing internal chemical reactions. During transportation, it is recommended to stabilize the load slowly to avoid sudden brakes and bumps to ensure the safety of the material.
In short, throughout the storage and transportation of dihydroxyacetone, careful attention must be paid to the temperature and humidity, chemical compatibility, packaging and transportation vibration to ensure its quality and safety.