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What is the chemical structure of 2-Amino-N- (2-chloro-6-methylphenyl) thiazole-5-carboxamide?
This is the name of an organic compound, interpreted in modern chemical language, 2 - Amino - N - (2 - chloro - 6 - methylphenyl) thiazole - 5 - carboxamide, its chemical structure can be analyzed as follows.
The main structure of this compound is a thiazole ring, with a formamide group (-CONH 2) attached to the thiazole ring at position 5, and a 2-chloro-6-methylphenyl group attached to the nitrogen atom of the formamide group. At the same time, the thiazole ring at position 2 is connected with an amino group (-NH 2).
In ancient Chinese, the structure of this compound can be described as: a thiazole ring, the fifth position of the ring, the group of formamide, the nitrogen position of formamide, followed by the phenyl group of 2-chloro-6-methyl. The second position of the ring, and the amino group. In this way, the unique chemical structure of this organic compound is formed. In its structure, the groups are connected to each other, which together determine the chemical properties and reactivity of this compound.
What are the main uses of 2-Amino-N- (2-chloro-6-methylphenyl) thiazole-5-carboxamide
2 - Amino - N - (2 - chloro - 6 - methylphenyl) thiazole - 5 - carboxamide, this is an organic compound. Its main use involves the field of medical drug research and development.
In the development of anti-cancer drugs, this compound may have unique effects. Its structural characteristics enable it to interact with specific targets in cancer cells, or inhibit the proliferation of cancer cells and induce cancer cell apoptosis. It is like a sharp blade in ancient times, accurately attacking the enemy's key points, providing a new opportunity to overcome cancer problems. For example, experimental studies have found that it has a significant inhibitory effect on the growth of some specific types of cancer cell lines, just like a strong suppressive force on the enemy on the battlefield.
It also shows potential value in the research and development of antimicrobial drugs. With its special chemical structure, it may interfere with the key metabolic pathways of bacteria and destroy the synthesis of bacterial cell walls or cell membranes, which is like building a strong barrier, making it difficult for bacteria to survive and multiply. Just like ancient fortifications, blocking foreign invaders, it is expected to become a key component of new antimicrobial drugs to help humans fight bacterial infections and diseases.
In addition, in the field of agriculture, there are also possible applications. Or it can be used as a new type of pesticide ingredient to control crop diseases and pests. By interfering with the physiological process of pests or pathogenic bacteria, it protects crops from damage, just like putting a layer of protective armor on crops to protect agricultural production and harvest, which is of great significance to ensuring food security and sustainable agricultural development.
What are the physical properties of 2-Amino-N- (2-chloro-6-methylphenyl) thiazole-5-carboxamide?
2-Amino-N- (2-chloro-6-methylphenyl) thiazole-5-formamide, the physical properties of this substance are quite important, and it is related to its performance in various applications.
Its appearance often takes a specific form. It is either crystalline, with fine grains and a lustrous luster. It looks like a fine pearl, shimmering in light; it is also powdery, uniform in texture, delicate as dust, and silky to the touch.
When it comes to melting point, this is one of the key physical properties. After rigorous determination, its melting point is within a certain temperature range. This temperature limit is like a ruler, defining the critical state of the transition from solid to liquid. When the external temperature gradually rises to the melting point, the thermal motion of the material molecules intensifies, the lattice structure begins to loosen, and finally the orderly arrangement of the solid state disintegrates, turning into a liquid flow state.
In terms of solubility, it varies in different solvents. In polar solvents, due to the matching of intermolecular forces, it may show a certain solubility, and the molecules seem to be able to blend with the solvent molecules and coexist harmoniously; in non-polar solvents, the solubility may be poor, and the two seem to be incompatible and difficult to blend.
Density is also a key consideration. Its density reflects the degree of compactness of the internal structure of a material, just like measuring whether a building is stacked tightly or not. The specific density value determines its ups and downs in different media. In practical operation and application scenarios, this characteristic should not be underestimated.
In addition, its stability is also an important part of physical properties. Under normal conditions of normal temperature and pressure, it may be able to maintain a relatively stable state, and the molecular structure is quiet and does not change easily. However, in case of extreme temperature, humidity or light conditions, its stability may be challenged, and the chemical bonds between molecules may be stirring, breaking or rearranging, causing changes in material properties.
What are the synthesis methods of 2-Amino-N- (2-chloro-6-methylphenyl) thiazole-5-carboxamide
The synthesis of 2-amino-N- (2-chloro-6-methylphenyl) thiazole-5-formamide is of particular importance. In the past, various paths have been used to synthesize this compound.
One method is to use a compound containing a thiazole ring as the starting material. Under specific reaction conditions, a halogenation reaction occurs at a specific position on the thiazole ring to introduce a halogen atom, which is crucial in the subsequent reaction. Next, the product containing the halogenated thiazole ring and the compound containing the amino and benzene rings are catalyzed by a base, and nucleophilic substitution is carried out in a suitable solvent. The base can promote the reaction, and the solvent provides a suitable reaction environment, so that the two can be combined smoothly to form a preliminary product. Afterwards, the preliminary product is amidated, and a suitable acylating agent is used to form an amide bond at a specific position under mild reaction conditions, so as to obtain the target product 2-amino-N - (2-chloro-6-methylphenyl) thiazole-5-formamide.
Another way to synthesize is to use benzene ring derivatives as starting materials. The benzene ring is first chlorinated and methylated to precisely control the reaction check point and degree to obtain 2-chloro-6-methylbenzene derivatives. At the same time, the precursor containing thiazole-5-formamide structure was prepared. Then, through ingenious reaction design, the benzene derivative condensed with thiazole-5-formamide precursor, or through key steps such as building carbon-nitrogen bonds, the target molecular structure was gradually established, and finally the synthesis of 2-amino-N - (2-chloro-6-methylphenyl) thiazole-5-formamide was achieved.
The synthesis process requires fine control of the reaction conditions, such as temperature, time, and the proportion of reactants. If there is a slight difference, the purity and yield of the product will be affected. And after each step of the reaction, the separation and purification operation should be properly carried out to ensure the quality of the intermediate product and the final product before the pure 2-amino-N - (2-chloro-6-methylphenyl) thiazole-5-formamide can be obtained.
2-Amino-N- (2-chloro-6-methylphenyl) What are the precautions in the use of thiazole-5-carboxamide
2-Amino-N - (2-chloro-6-methylphenyl) thiazole-5-formamide. When using this product, many matters need to be paid attention to.
First, safety is the most important. Due to its chemical properties, it may be toxic and irritating. When in contact, appropriate protective equipment must be worn, such as gloves, goggles and protective clothing, to prevent skin, eyes and respiratory tract damage. After operation, be sure to wash hands and expose skin, do not allow residue to remain.
For the second time, storage is also critical. It should be placed in a cool, dry and well ventilated place, away from fire, heat and oxidants. If it is improperly stored, or deteriorated, it will affect its performance, or even cause a safety accident.
Furthermore, when taking it, accurate measurement is crucial. According to the experimental or production requirements, measure with accurate measuring tools. Do not increase or decrease the dosage at will to avoid errors and affect the reaction process and product quality.
Repeat, the use environment needs to be clean and regular. Avoid impurities from mixing in and interfering with the reaction. And the operation table and equipment should be cleaned before and after use.
Also, be familiar with its chemical properties and reaction characteristics. Know what kind of reaction the substance can participate in and what conditions are used, so that the reaction can be effectively controlled and dangerous situations can be avoided.
In the last case, in the event of an accident, such as leakage or contact with human body, deal with it as soon as possible according to the established emergency measures. Small amount of leakage, collect in a suitable container; large amount of leakage, evacuate personnel, isolate the scene, and report to professionals for disposal. In contact with human body, rinse immediately with a large amount of water, and seek medical attention in severe cases.
In short, use 2-amino-N - (2-chloro-6-methylphenyl) thiazole-5-formamide, when careful, follow the specifications to ensure safety and effect.