2-Amino-alpha-(methoxyimino)-4-thiazoleacetic acid

2-Amino - α -（ methoxyimino) -4-thiazoleacetic acid is an important organic compound. It has a wide range of uses and has made significant contributions to the field of medicine.
The compound has a unique chemical structure and activity, and is a key intermediate in the synthesis of many antibiotics. Taking cephalosporins as an example, 2-amino - α -（ methoxyimino) -4-thiazoleacetic acid plays an indispensable role in its synthesis process. It can participate in the construction of the core structure of cephalosporins, and through a series of chemical reactions, endows antibiotics with better antibacterial activity, wider antibacterial spectrum and higher stability.
In addition, in the field of pesticides, this compound has also been involved. Due to its certain characteristics, it can be used as a raw material for the synthesis of specific pesticides, and can help to develop new pesticides with high efficiency, low toxicity and environmental friendliness, providing strong support for agricultural pest control.
In addition, in the study of organic synthetic chemistry, 2-amino - α -（ methoxyimino) - 4-thiazoleacetic acid as a characteristic reactant provides an effective tool for researchers to explore novel organic synthesis paths and create new compounds, which promotes the continuous development of the field of organic synthetic chemistry.

The synthesis of 2-amino - α -（ methoxyimino) -4-thiazole acetic acid involves a variety of approaches. In the past, the classic method was to go through a multi-step reaction. At the beginning, a specific thiazole derivative was used as the starting material, and the reaction conditions were carefully designed to make it interact ingeniously with nitrogenous and oxygen-containing reagents. In this process, the temperature, pH and reaction time of the reaction were skillfully controlled to make each step of the reaction advance accurately. < Br >
or shilling thiazole derivatives and halogenated methoxy compounds under the catalysis of bases undergo nucleophilic substitution reactions. In this step, the strength and dosage of bases are critical. Too much or too little dosage may affect the reaction yield or generate by-products. Then, through a specific amination reaction, amino groups are ingeniously introduced. In this step, suitable amination reagents and reaction solvents need to be selected to ensure the smooth progress of the reaction and good selectivity.
There are modern synthesis methods, with the help of new catalysts and green chemistry concepts. The coupling reaction catalyzed by transition metals can efficiently construct key chemical bonds of target molecules. This method has the advantages of mild reaction conditions and simple steps, which greatly improves the synthesis efficiency and atomic economy. And the reaction solvent also tends to choose environmentally friendly ones to keep up with the current trend of green chemistry. At the same time, in the process of reaction monitoring and product purification, there are also advanced technical means, such as chromatographic analysis, which can accurately monitor the reaction process, and a variety of purification methods can be combined to obtain high-purity products.

2-Amino - α -（ methoxyimino) - 4-thiazoleacetic acid, an organic compound, is widely used in the field of medicine and chemical industry, especially in the synthesis of cephalosporins, as a key intermediate. Its physical and chemical properties are unique, which is of great significance to related research and production.
Looking at its properties, it is a white-like to light yellow crystalline powder under normal conditions, with a fine texture. This state is conducive to storage and transportation, and lays the foundation for subsequent reactions.
The melting point is about 195-198 ° C. As an important physical index of substances, the melting point is of great significance for judging its purity and stability. In this temperature range, the substance melts from a solid state to a liquid state. This property can help identify its purity. If there are many impurities, the melting point may drop and the melting range will increase.
Solubility is also a key property. It is slightly soluble in water and has a certain solubility in polar organic solvents such as methanol and ethanol. This solubility has a far-reaching impact on the synthesis and separation process. It can be used to select suitable solvents for efficient reaction and separation.
In terms of chemical properties, the amino groups in the molecular structure are basic and can react with acids to form salts. The methoxy imino and thiazole ring parts give the molecule unique reactivity and can participate in various organic reactions, such as reacting with acyl chloride to form amide bonds, which is a key step in the synthesis of cephalosporins. The carboxyl group is also acidic, can be neutralized with bases, and can also participate in esterification reactions. Through these reactions, the molecular structure can be modified to obtain the desired performance compound.
In addition, the substance needs attention to light and thermal stability. Under high temperature or strong light, decomposition or structural changes may occur, causing it to lose its reactivity. When storing and using, it should be protected from high temperature and strong light, and stored in a cool, dry and dark place to ensure its quality and performance stability.

2-Amino - α -（ methoxyimino) - 4-thiazoleacetic acid, the range of market prices varies with time and market conditions, and it is difficult to have a definite number. In the past, the price of such substances was affected by various factors such as supply and demand, production methods, and raw materials.
Looking at the past, if the production method is excellent, the raw materials are easy to obtain and abundant, and there are many people in the market, the price may tend to be flat, or even slightly reduced. On the contrary, if the production method is difficult, the raw materials are rare, and the supply is not enough, the price will rise.
In the early years, this chemical has gradually prospered in various industries, and there are many people who seek it, but it is not easy to make it, and the price is often high. The post-production method is refined, and the raw materials also have new sources, and the price is slowly decreasing.
Recently, the chemical technology has been more advanced, and the output has increased. If the market demand does not change greatly, the price may fluctuate within a certain range. If you want to know the price, you must check the current chemical market situation, the prices of various producers, and depend on the changes in the price of raw materials, trade policies, etc. Roughly speaking, the price varies from hundreds to thousands of yuan per kilogram under different quality and quantity, which is difficult to generalize.

2-Amino - α -（ methoxyimino) - 4-thiazoleacetic acid is a key raw material in organic synthesis and is widely used in the field of medicine and chemical industry. Its Quality Standard covers many important aspects.
First, it is related to appearance. This substance usually appears as a white to off-white crystalline powder with uniform color and no visible impurities. Looking at its shape, it is delicate and regular, like a carefully carved micro-crystal, which is the initial consideration for judging its quality.
Second, purity is crucial. Its purity generally needs to reach more than 98.0%, or even higher standards. Only high purity can ensure that it can play a stable role in various reactions and applications. The amount of impurities directly affects its performance and the quality of subsequent products. This is like refined gold needs to be removed to store cyanine, and purity is the cornerstone of quality.
Third, the melting point is also a key indicator. Its melting point range is usually between 190-194 ° C. Precise melting point, just like the unique identification of a substance, reflects the regularity and stability of its internal structure. If the melting point deviation is too large, it implies that its molecular structure may be mutated, and the quality may be difficult to guarantee.
Fourth, the moisture content. The moisture content should be controlled below 0.5%. Excessive moisture, like fine sand mixed into sophisticated equipment, will interfere with its chemical reaction process and reduce the yield and quality of the product. Therefore, strict control of moisture is a necessary measure to maintain its quality.
In addition, the content of heavy metals cannot be ignored. The content of heavy metals such as lead, mercury, and cadmium must meet strict limit standards, and the general requirements are extremely low to ensure the safety of their application in medicine and other fields and avoid potential harm to organisms.
These Quality Standards are interconnected to build a strong defense line for the quality of 2-amino - α -（ methoxyimino) - 4-thiazoleacetic acid to ensure that it plays its due role in industrial production and scientific research applications.