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What is the chemical structure of -2-amino-6-propionamido--4, 5, 6, 7-tetrahydrobenzothiazole?
The chemical structure of (±) -2 -amino-6-propionamido-4,5,6,7-tetrahydrobenzothiazole is involved in the field of organic chemistry. This compound is derived from the benzothiazole parent nucleus.
Looking at its structure, the benzothiazole parent nucleus is the basis, and it is formed by fusing the benzene ring with the thiazole ring. There is an amino group connected at the 2 position, and the amino group is a common nitrogen-containing functional group in organic compounds. It has certain basic properties and can participate in many chemical reactions, such as salting with acids, or participating in nucleophilic substitution under specific conditions.
The 6-position connection to the propionamide group is formed by the condensation of the propionyl group and the amino group. This structure endows the compound with specific chemical and physical properties, which affect its solubility and reactivity.
The tetrahydro structure at positions 4,5,6,7 indicates that the benzene ring part of the parent nucleus of benzothiazole is not a completely conjugated aromatic structure, but is partially hydrogenated to form a saturated or partially saturated carbon ring structure. This tetrahydro structure changes the electron cloud distribution and spatial configuration of the parent nucleus, and also has a significant impact on the overall stability, biological activity and physical properties of the compound.
Overall ,(±) - the interaction of groups in the chemical structure of 2-amino-6-propionamido-4,5,6,7-tetrahydrobenzothiazole jointly determines the unique chemical and physical properties of the compound, which may have important research value and application potential in the fields of organic synthesis and medicinal chemistry.
(-) What are the physical properties of -2-amino-6-propionamido--4, 5, 6, 7-tetrahydrobenzothiazole
The physical properties of (±) -2 -amino-6-propionamido-4,5,6,7-tetrahydrobenzothiazole are as follows:
This compound is mostly white to light yellow crystalline powder at room temperature, with a pure color and fine texture. Its melting point is quite critical, about [X] ° C. This temperature is the critical point for its transition from solid to liquid state. In many reactions and purification processes, the melting point is often an important reference index.
In terms of solubility, this substance exhibits certain solubility properties in organic solvents such as ethanol and dichloromethane. In an appropriate amount of ethanol, with a moderate increase in temperature, the dissolution rate accelerates, and the solubility also increases. This is due to the increase in temperature, the thermal motion of molecules intensifies, and the interaction between solvent and solute molecules enhances. In water, its solubility is relatively low, which is related to the presence of hydrophobic groups in the molecular structure, and the hydrophobic part hinders its full interaction with water molecules.
Its density is also an important physical property, about [X] g/cm ³, which reflects its mass per unit volume. When materials are stored, transported, and involved in certain reactions, density affects the space occupied by substances and the mixing ratio with other substances.
In addition, its appearance is stable, and under normal storage conditions, deliquescence or agglomeration is not easy to occur, which provides convenience for its preservation and use. In case of extreme conditions such as strong light and hot topic, its physical shape may change slightly, such as a slightly darker color, so it needs to be stored in a cool and dark place.
(-) What are the synthesis methods of -2-amino-6-propionamido--4, 5, 6, 7-tetrahydrobenzothiazole
There are various ways to synthesize (±) -2 -amino-6-propionamido-4,5,6,7-tetrahydrobenzothiazole.
First, start with sulfur-containing and nitrogen-containing raw materials. First, take suitable thiols or thiophenols, and nitrogen-containing enamines or amide derivatives. Under specific reaction conditions, such as in inert solvents, add an appropriate amount of catalysts, such as some metal salts or organic bases, and heat up to a certain temperature to make it undergo nucleophilic substitution or cyclization. During this process, sulfur atoms interact with nitrogen atoms to gradually build the basic structure of benzothiazole.
Second, it can start from the parent benzothiazole with suitable substituents. First modify the parent substituent, such as introducing halogen atoms with appropriate halogenated reagents, and then carry out nucleophilic substitution reaction with the nucleophilic reagent related to the propionamide group under the action of a base, so that the propionamide group is introduced into the 6 position of the benzothiazole ring, and then through appropriate reduction steps, the 4, 5, 6, and 7 positions of the benzothiazole ring are hydrogenated to achieve the structure of tetrahydro, while retaining the amino group at the 2 position.
Third, a multi-step tandem reaction strategy is adopted. First, through a multi-component reaction, the sulfur-containing source, nitrogen-containing source and the raw materials for constructing the benzene ring are preliminarily formed into the prototype of benzothiazole in a one-pot reaction under special catalyst and reaction environment, and then the obtained product is functionally converted, and 2-amino and 6-propionamide groups are gradually added. Finally, through the reduction process, the target product (±) -2-amino-6-propionamido-4,5,6,7-tetrahydrobenzothiazole is obtained. Each method has its own advantages and disadvantages, and the selection needs to be weighed according to factors such as the availability of raw materials, the difficulty of reaction, and the purity requirements of the target product.
(-) What are the application fields of -2-amino-6-propionamido--4, 5, 6, 7-tetrahydrobenzothiazole
(±) -2 -Amino-6-propionamido-4,5,6,7-tetrahydrobenzothiazole is one of the organic compounds. Its application field is quite wide, let me know one by one.
In the field of medicine, this compound can be used as a drug intermediate. The structure of tetrahydrobenzothiazole is often biologically active and can interact with specific targets in organisms. On this basis, chemists can modify its substituents to develop drugs with antibacterial, anti-inflammatory, anti-tumor and other effects. For example, some antibacterial drugs can enhance the inhibitory ability of bacterial cell wall synthesis through the structural modification of this compound, achieving the purpose of antibacterial.
In the field of pesticides, it is also used. In the creation of some pesticides, (±) -2 -amino-6-propionamido-4,5,6,7 -tetrahydrobenzothiazole is used as the starting material. After chemical modification, pesticides with insecticidal, bactericidal or herbicidal activities can be obtained. Such pesticides can target specific pests or weeds and play a control effect by interfering with their physiological and metabolic processes, and have relatively little impact on the environment, which is in line with the development trend of green pesticides today.
Furthermore, in the field of materials science, this compound may participate in the preparation of functional materials. Its special chemical structure may endow the material with unique physical and chemical properties. For example, in some optical materials, it can be used as a structural unit to affect the luminous properties or light stability of the material, and then prepare materials with specific optical properties for optical devices, display technology, etc.
(±) -2 -amino-6-propionamido-4,5,6,7 -tetrahydrobenzothiazole has important applications in the fields of medicine, pesticides and materials science, providing a key foundation for the development of related fields.
(-) -2-amino-6-propionamido--4, 5, 6, 7-tetrahydrobenzothiazole market prospects
(±) -2 -Amino-6-propionamido-4,5,6,7-tetrahydrobenzothiazole is an organic compound. Looking at its market prospects, it needs to be examined in detail from various angles.
First of all, it is in the field of medicine, or has unique pharmacological activities, and can be used as potential drug intermediates. Today's pharmaceutical industry is eager for innovative drugs, and new compounds are the cornerstone of the development of new drugs. If this compound can demonstrate specific physiological activities after research, such as affinity and regulation of certain disease targets, pharmaceutical companies must pay great attention to its raw material supply and synthesis process improvement, and market demand may increase.
The chemical industry cannot be ignored either. In the field of organic synthesis, a variety of intermediates are often required to build complex molecular structures 。(±) - the special structure of 2-amino-6-propionamido-4,5,6,7-tetrahydrobenzothiazole or the key building blocks for the synthesis of specific functional materials and fine chemicals. Chemical companies may have requirements for such compounds due to the development of new products.
However, its market expansion also faces challenges. If the synthesis process is complex and costly, large-scale production and marketing activities will be hindered. And when new compounds are put into the market, safety and Environmental Impact Assessment are essential. Only after rigorous evaluation to ensure that they are harmless to human beings and the environment can they be sold in the market.
In summary ,(±) - 2-amino-6-propionamido-4,5,6,7-tetrahydrobenzothiazole has an addressable market opportunity, but to turn the potential into actual market share, it still needs scientific research, production and other unremitting efforts to overcome technical problems and meet regulatory requirements before it can emerge in the market.