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What is the main use of 2-amino-6- (methylsulfonyl) benzothiazole?
2-Amino-6- (methylsulfonyl) benzothiazole, which is 2-amino-6- (methylsulfonyl) benzothiazole, is widely used.
In the field of medicinal chemistry, it is often a key intermediate for the creation of new drugs. The structure of Gein benzothiazole has unique biological activities and pharmacological properties. Based on this, chemically modified and derived, a variety of compounds with specific physiological activities can be obtained, such as antibacterial, anti-inflammatory, anti-tumor and other drugs. For example, by modifying its amino and methylsulfonyl sites, the interaction between compounds and biological targets can be regulated, and the efficacy and selectivity of drugs for specific diseases can be improved. < Br >
In the field of materials science, it is also useful. It can be used as an important raw material for the synthesis of functional materials, such as the preparation of materials with special optical and electrical properties. Due to its structural characteristics, it can endow materials with unique light absorption and emission properties, and may play an important role in optoelectronic materials, fluorescent probes and other fields. For example, in the design of fluorescent probes, the structure of 2-amino-6- (methylsulfonyl) benzothiazole can be modified to produce specific responses to specific ions or molecules, and sensitive detection of the target can be achieved by changing the fluorescence signal.
In addition, in the field of agricultural chemistry, compounds made from this raw material may have insecticidal and bactericidal activities. Through rational molecular design and optimization, high-efficiency, low-toxicity and environmentally friendly pesticide products can be developed, providing assistance for crop pest control.
What are the synthesis methods of 2-amino-6- (methylsulfonyl) benzothiazole
To prepare 2-amino-6- (methylsulfonyl) benzothiazole, there are many methods, which are described in detail below.
First, 2-aminobenzothiazole is used as the starting material, and the target product can be obtained by the sulfonation method. Among them, choose a suitable sulfonating reagent, such as fuming sulfuric acid or chlorosulfonic acid. At a specific temperature and reaction time, the sulfonating reagent meets 2-aminobenzothiazole, and the two combine to form 2-amino-6- (methylsulfonyl) benzothiazole. When operating, pay attention to the control of the reaction temperature. If it is too high, side reactions will occur, and if it is too low, the reaction will be slow, which is not conducive to the production of the product.
Second, o-aminothiophenol and methyl sulfonyl chloride can also be used as raw materials and cyclized through condensation. First, the o-aminothiophenol and methyl sulfonyl chloride meet in the alkali solution, the two condensate, and then cyclize to form the shape of benzothiazole. In this process, the amount of base and the choice of reaction solvent are all key. Improper alkali content makes the reaction difficult; solvent discomfort also hinders the reaction process. < Br >
Third, other small molecules containing sulfur and nitrogen can be used to gradually construct benzothiazole rings and introduce methyl sulfonyl groups. Although this approach is a little complicated, if the design is exquisite, a pure product can also be obtained. For example, the intermediate containing sulfur and nitrogen is prepared first, and then the desired group is gradually added through a multi-step reaction to eventually form the target product. Each step of the reaction needs to be carefully controlled to achieve the desired result.
All these methods have advantages and disadvantages. When actually preparing, according to the availability of raw materials, cost considerations, product purity and other factors, careful selection can be made to obtain high-efficiency and high-quality 2-amino-6- (methylsulfonyl) benzothiazole.
What are the physical and chemical properties of 2-amino-6- (methylsulfonyl) benzothiazole
2-Amino-6- (methylsulfonyl) benzothiazole, this is an organic compound. Its physical and chemical properties are crucial and related to applications in many fields.
Looking at its properties, at room temperature and pressure, it is mostly in the state of white to light yellow crystalline powder. This form is conducive to storage and transportation, because it is relatively stable, it is not easy to change significantly under conventional conditions.
When it comes to the melting point, it is about 190-194 ° C. As a material characteristic, the melting point is extremely important for the detection of its purity and the control of its state under a specific temperature environment. At this temperature range, the compound gradually melts from solid to liquid. The precise temperature measurement of this process can help determine its purity.
Solubility is also an important property. It is slightly soluble in water, but it has good solubility in some organic solvents, such as dichloromethane, N, N-dimethylformamide. This property makes it possible to choose a suitable organic solvent to promote the reaction according to the needs of the reaction, or to separate and purify the compound.
In terms of chemical properties, the amino group in 2-amino-6- (methylsulfonyl) benzothiazole has a certain basic nature and can react with acids to form corresponding salts. This reaction property can be used in drug synthesis to improve the solubility and stability of drugs. The presence of benzothiazole ring and methyl sulfonyl group makes the compound have a certain electronic effect and space effect, which affects its chemical reactivity and selectivity. It needs to be considered in detail in the design of the reaction path of organic synthesis.
What is the price of 2-amino-6- (methylsulfonyl) benzothiazole in the market?
What you are asking is the price of 2-amino-6- (methylsulfonyl) benzothiazole in the market. However, this is a rather professional chemical, and its price often varies depending on many factors such as quality, purity, purchase quantity, and market conditions.
In terms of the ancient meaning of "Tiangong Kaiwu", the price of all things in the world has its own reasons. If this product is of high quality and purity, the price must be higher than usual. And if the purchase quantity is huge, you may get a preferential price, such as the ancient merchants, who often get a profit when purchasing in bulk.
Today's chemical market is unpredictable, and the relationship between supply and demand also affects its price. If the demand for this product is strong and the supply is low, the price will rise; conversely, if the supply exceeds the demand, the price may drop.
If you want to know the exact price, you should consult the chemical reagent supplier or visit the relevant chemical product trading platform. There can tell you the price of this product according to the current situation. You must not just infer according to common sense. You need to seek it yourself to get an accurate price. Just like the ancients who wanted to know, they must investigate it in person to know the details.
What are the manufacturers of 2-amino-6- (methylsulfonyl) benzothiazole?
2 - amino - 6 - (methylsulfonyl) benzothiazole is an important organic compound, which is widely used in many fields such as medicine and pesticides. However, I have been searching for ancient books, and there are few detailed records about the manufacturer of this compound. Although this is the case, I still find some clues from the clues.
Looking at the current chemical industry, some manufacturers focus on the manufacture of fine chemicals, or are involved in the production of this compound. Gai because of his expertise in complex organic synthesis processes and a complete R & D and production system. Such manufacturers often rely on their profound technical accumulation and innovation ability to overcome the problems of synthesizing such compounds.
Other companies that mainly produce pharmaceutical intermediates may also produce 2-amino-6 - (methylsulfonyl) benzothiazole. As pharmaceutical intermediates, they are essential for drug synthesis. Therefore, in order to meet the market demand for pharmaceutical raw materials, such companies may invest resources in the production of this compound.
If you want to know the name of the manufacturer, you need to go deep into the chemical market, check various chemical product directories, industry exhibition materials, or communicate with chemical industry veterans to obtain more accurate and detailed information. Although I have tried my best, I am limited to what I know. It is a pity that I cannot describe all the manufacturers. If more information emerges in the future, it will be detailed.