What are the main uses of 2-AMINO-5-TRIFLUOROMETHYLBENZOTHIAZOLE?

2-Amino-5-trifluoromethylbenzothiazole is one of the organic compounds. It has a wide range of uses and is used in many fields.

In the field of medicinal chemistry, this compound is often used as a key intermediate. Due to its unique chemical structure, it can be derived from various chemical reactions with biologically active drug molecules. For example, in the development of antibacterial and antiviral drugs, it can be used as a starting material to construct drugs with specific mechanisms of action against pathogens through ingenious synthesis paths to achieve the purpose of treating diseases.

In the field of materials science, 2-amino-5-trifluoromethylbenzothiazole also has important uses. It can be used to prepare functional materials, such as materials with special optical and electrical properties. Because of its trifluoromethyl content, it can endow materials with unique physical and chemical properties, such as improving the stability and solubility of materials, and affecting the electron cloud distribution of materials, thereby changing their optical and electrical properties. It plays an important role in the preparation of optoelectronic materials and sensor materials.

Furthermore, in agricultural chemistry, it may participate in the synthesis of new pesticides. By reacting with other chemical substances, pesticide products that are effective in controlling pests and weeds and environmentally friendly are created to promote sustainable agricultural development. In short, the structural characteristics of 2-amino-5-trifluoromethylbenzothiazoline have shown important application value in many fields such as medicine, materials, and agriculture.

What are the physical properties of 2-AMINO-5-TRIFLUOROMETHYLBENZOTHIAZOLE?

2-Amino-5-trifluoromethylbenzothiazole is an organic compound with unique physical properties. Its color state is often off-white to light yellow crystalline powder, which is convenient for preliminary judgment in substance identification.

In terms of melting point, it is about 148-152 ° C. As an important physical constant of a substance, the melting point is of great significance in the identification and purification process. In this temperature range, the compound changes from solid to liquid. This property can help determine its purity. If the purity is high, the melting point range is narrow and close to the theoretical value; if it contains impurities, the melting point is reduced and the range is wider.

The solubility of the compound is also a key physical property. Slightly soluble in water, because water is a strong polar solvent, while 2-amino-5-trifluoromethylbenzothiazole has limited polarity, and is difficult to dissolve in water according to the principle of "similar miscibility". However, it is soluble in common organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), etc. In dichloromethane, due to the appropriate polarity and solubility of dichloromethane, the compound can be uniformly dispersed to form a solution, which is conducive to being used as a reaction medium in organic synthesis reactions or for separation and purification.

In addition, the compound has certain stability, but under specific conditions, such as high temperature, strong acid and strong alkali environment, the structure may change. Because it contains amino groups and benzothiazole rings, amino groups are basic and can react with acids; benzothiazole rings make compounds exhibit unique activities in certain chemical reactions. Understanding these physical properties is crucial for their applications in organic synthesis, drug discovery and other fields.

What are 2-AMINO-5-TRIFLUOROMETHYLBENZOTHIAZOLE synthesis methods?

The synthesis method of 2-amino-5-trifluoromethylbenzothiazole has been known since ancient times and has been described in many books. One common method is to use aniline derivatives containing specific substituents as starting materials. Schilling aniline derivatives and appropriate thioreagents, such as thiophosgene or carbon disulfide, are co-placed in a reactor under suitable reaction conditions. Adjust the temperature and pressure of the reaction, or add a specific catalyst to make the two condensation reactions occur, and the initial sulfur-containing intermediate is formed. Then, the intermediate is cyclized, or by heating, or by introducing reagents to promote cyclization, the atoms in the molecule are rearranged and cycled, and the final product is 2-amino-5-trifluoromethylbenzothiazole.

The second method can be started from halogenated benzothiazole. Select benzothiazole with appropriate halogen atom substitution, and place it in the reaction system with reagents containing amino groups and trifluoromethyl groups in a basic environment. The base can promote the nucleophilic substitution reaction between reagents, the halogen atom leaves, and the amino group and trifluoromethyl are connected to the specific position of benzothiazole, so the target product is obtained. When reacting, it is necessary to pay attention to the type and dosage of bases, because it has a great influence on the rate and selectivity of the reaction.

There are also those who synthesize this compound with a heterocyclic construction strategy. First synthesize the heterocyclic fragment containing part of the target structure, and then gradually construct the complete 2-amino-5-trifluoromethylbenzothiazole structure by means of functional group transformation and ring splicing. This process requires fine planning of the reaction steps, consideration of the conditions of each step of the reaction and the control of side reactions, in order to achieve the purpose of efficient synthesis.

What is the price range of 2-AMINO-5-TRIFLUOROMETHYLBENZOTHIAZOLE in the market?

The price range of 2-amino-5-trifluoromethylbenzothiazole in the market is difficult to say exactly. This is due to the interplay of many factors, resulting in price fluctuations.

The first to bear the brunt is at the end of production and supply. If the preparation process of this product is complicated, the raw materials are scarce and rare, or there are few manufacturers and insufficient supply, the price will be higher. On the contrary, the process is energetic, the raw materials are abundant and there are many manufacturers, and the supply is abundant, and the price may be lower.

The demand level also has a great impact. If there is a strong demand for this product in the fields of medicine, chemical industry, etc., but the supply is difficult, the price will rise; when the demand is low, the manufacturer will sell it for promotion or reduce its price.

Furthermore, the market competition situation affects the price. The competition in the same industry is fierce, and each manufacturer may compete for share or implement price strategies, and the price may become more flexible and changeable.

According to past market conditions, the price varies significantly under different purity, packaging specifications and purchase quantities. For small purchases and high purity, the price per gram may reach tens or even hundreds of yuan; for large purchases and non-extreme purity requirements, the price per kilogram may be around thousands of yuan.

However, the market changes, the rise and fall of raw material prices, changes in policies and regulations, and unexpected events can all cause their prices to fluctuate. To know the exact price range, it is recommended to consult chemical raw material suppliers, distributors, or check the latest quotations on the relevant chemical product trading platform.

What are 2-AMINO-5-TRIFLUOROMETHYLBENZOTHIAZOLE manufacturers?

2-Amino-5-trifluoromethylbenzothiazole is an important compound in the field of organic synthesis, and its preparation often involves multi-step organic reactions. In modern times, many chemical companies and research institutions have devoted themselves to the production of this compound.

Viewpoint of Huaxia, Jiangsu, some fine chemical enterprises, with profound technical accumulation and advanced production equipment, can stably produce high-quality 2-amino-5-trifluoromethylbenzothiazole. After long-term research and development and practice, their enterprises have optimized the synthesis process and improved the purity and yield of products.

Furthermore, Shandong also has a number of enterprises specializing in the production of heterocyclic compounds, and they are also involved in the production of 2-amino-5-trifluoromethylbenzothiazole. With its efficient synthesis route and strict quality control system, the products produced are supplied to many domestic pharmaceutical and pesticide manufacturers.

There are also many overseas manufacturers of this compound. For example, some well-known chemical companies in Europe and the United States have gained a place in the global market with their cutting-edge research and development technology and large-scale capacity. Their products are not only supplied locally, but also exported to all parts of the world.

In addition, some chemical companies in India are also actively involved in the production of 2-amino-5-trifluoromethylbenzothiazole due to their cost advantages. They produce competitively priced products with lower cost raw materials and manpower, and are quite influential in the international market.

In summary, the manufacturers of 2-amino-5-trifluoromethylbenzothiazole are widely distributed, and many domestic and foreign companies are making efforts in this field to promote the production and application of this compound with their respective advantages.