2-Amino-5-fluorobenzothiazole

2-Amino-5-fluorobenzothiazole is an important member of organic compounds. It has a wide range of uses in the field of medicinal chemistry, and is mostly a key intermediate for the creation of new drugs. The structure of Gein-benzothiazole has unique biological activity, introducing amino and fluorine atoms, which can optimize the affinity and selectivity of drugs to specific targets. For example, in the development of anti-cancer drugs, its structural modification can enhance the targeting effect of drugs on cancer cells, improve efficacy, and reduce damage to normal cells.
In the field of materials science, 2-amino-5-fluorobenzothiazole also shows extraordinary potential. It can be used to prepare functional materials, such as optoelectronic materials. Due to the introduction of fluorine atoms, the electron cloud distribution of the material can be adjusted, affecting its optical and electrical properties. The photoelectric materials prepared from this compound as raw materials may have excellent fluorescence properties and charge transport capabilities, and are expected to be applied to optoelectronic devices such as organic Light Emitting Diodes (OLEDs) to improve their luminous efficiency and stability.
Furthermore, in the field of pesticide chemistry, this compound is also promising. Due to its special structure, or endowing pesticides with unique biological activities, it can be used to develop new pesticides with high efficiency, low toxicity and environmental friendliness. By rationally modifying its structure, the killing effect of pesticides on specific pests or pathogens can be enhanced, the amount of pesticides used can be reduced, and the negative impact on the environment can be reduced. In conclusion, 2-amino-5-fluorobenzothiazole occupies an important position in many fields such as medicine, materials and pesticides. With the development of science and technology, its potential application prospects will continue to expand.

2-Amino-5-fluorobenzothiazole is one of the organic compounds. Its physical and chemical properties are quite impressive.
Looking at its physical properties, under normal conditions, or in a solid state. The melting point varies depending on factors such as the purity of the compound, but it is roughly within a specific temperature range. As for the boiling point, it also depends on many factors such as intermolecular forces. It exhibits different solubility in organic solvents. In polar organic solvents, such as ethanol, acetone, etc., or have a certain solubility, because their molecular structure contains polar groups, they can form interactions with polar solvents, such as hydrogen bonds, dipole-dipole interactions, etc., which enable them to partially dissolve in such solvents. In non-polar organic solvents, such as n-hexane, the solubility is relatively low, due to the weak interaction between non-polar solvents and the compound.
On its chemical properties, in the 2-amino-5-fluorobenzothiazole molecule, the amino group is connected to the benzothiazole ring, and the amino group has a certain alkalinity, which can react with the acid to form the corresponding salt. This is because there are lone pairs of electrons on the amino nitrogen atom, which can accept protons. Furthermore, the benzothiazole ring is aromatic and relatively stable, but under suitable conditions, electrophilic substitution reactions can still occur. The presence of fluorine atoms also affects its chemical properties. Fluorine atoms are highly electronegative, which can affect the distribution of electron clouds on the benzene ring through induction effects, so that the density of electron clouds in the adjacent and para-sites of the benzene ring is relatively reduced. Therefore, in the electrophilic substitution reaction, the substituents may be more inclined to enter the meta-site. The introduction of fluorine atoms enhances the stability of the molecule, and in some chemical reactions, it can change the activity and selectivity of the reaction. In addition, the compound can also participate in a variety of organic synthesis reactions, providing the possibility for the construction of more complex organic molecular structures.

The synthesis methods of 2-amino-5-fluorobenzothiazole have existed in ancient times, and there are many kinds. Today, several common methods are described in detail.
First, fluoroaniline-containing compounds are used as starting materials. First, fluoroaniline and thiocyanate are reacted under suitable conditions to form thiourea derivatives. This reaction requires precise control of temperature, reaction time and proportion of reactants. Too high or too low temperature may affect the formation of the product. After the reaction is completed, the obtained thiourea derivative is placed in a specific solvent and cyclized by heating to obtain 2-amino-5-fluorobenzothiazole. In this process, the choice of solvent is very critical, and different solvents may have a significant impact on the reaction rate and yield.
Second, halogenated fluorobenzene and thioformamide are used as raw materials. Halogenated fluorobenzene and thioformamide undergo nucleophilic substitution reaction first under the catalysis of bases. The strength and dosage of bases depend on whether the reaction can proceed smoothly. Then, the target product is obtained through internal cyclization of molecules. This synthesis path is relatively simple, but the reaction conditions also need to be carefully controlled.
Third, starting from 2-nitro-5-fluoroaniline. 2-Nitro-5-fluoroaniline is reduced to 2-amino-5-fluoroaniline. The commonly used reducing agents are iron powder, zinc powder, etc. After reduction, it reacts with carbon disulfide under basic conditions to form an intermediate product. Finally, 2-amino-5-fluorobenzothiazole is prepared by cyclization. In this process, the conditions of reduction and cyclization steps are optimized, which has a great impact on the purity and yield of the product.
All these synthesis methods have advantages and disadvantages. The appropriate synthesis method needs to be carefully selected according to actual needs, such as raw material availability, cost, product purity and other factors.

I don't know what the price range of 2 - Amino - 5 - fluorobenzothiazole is in the market. However, if you want to know the price of this product, you can find a clue or two in the method involved in "Tiangong Kaiwu". In the past, the price of various products often varied depending on the place of origin, supply and demand, age, etc.
Look at "Tiangong Kaiwu", which details all kinds of products and processes. Although the price of this chemical is not directly stated, it can be deduced. Where the price of the product is easy to produce, the price is cheap; if it is difficult to produce, the price is high. If the preparation of this product requires complicated processes and scarce raw materials, the price must be high.
Also, the supply and demand situation also affects its price. If the world uses this product more, there will be many people who ask for it, but there will be few people who supply it, and the price will increase; on the contrary, if the supply exceeds the demand, the price will drop.
Furthermore, the price varies depending on the age. In a good year, the price may be stable or drop; in a disaster year, the price will often rise. Although today is very different from the era recorded in "Tiangong Kaiwu", the reason for this pricing may be referred to. As for the determination of the price of 2-Amino-5-fluorobenzothiazole, it is also necessary to carefully investigate the chemical market conditions, ask merchants, and check transaction records before obtaining its approximate price range.

2-Amino-5-fluorobenzothiazole is a key intermediate in organic synthesis and is widely used in medicine, pesticides and other fields. As for its manufacturers, it is difficult to enumerate in detail, but in China, many fine chemical companies are involved in the production of this product.
In East China, there are enterprises that devote themselves to the manufacture of 2-amino-5-fluorobenzothiazole with exquisite craftsmanship and strict quality control. The craftsmen in the factory all have profound chemical attainments. With advanced equipment and cutting-edge technology, the products produced are of high quality and are supplied to the four sides.
There is no shortage of such manufacturers in South China. They focus on R & D innovation, continuously optimize production processes, and strive to improve product purity and output. The 2-amino-5-fluorobenzothiazole they produce is highly praised in the market and is sold all over the world.
Some manufacturers in North China rely on the advantages of local resources to supply this product stably with an efficient production model. They strictly abide by industry norms to ensure stable product quality and have a good reputation in the industry.
There are also overseas producers of 2-amino-5-fluorobenzothiazole. Some chemical companies in Europe and the United States have profound technical heritage and mature production processes. Their products also occupy a place in the international market.
To find a suitable manufacturer, it is necessary to comprehensively consider many factors such as product quality, price, supply capacity and corporate reputation. Through chemical industry exhibitions, professional websites, trade platforms and other channels, information can be collected from many parties and compared in detail, so as to obtain the favorite cooperative manufacturers to meet their own production or scientific research needs.