2-Amino-5-chlorothiazole

2-Amino-5-bromopyridine has a wide range of main uses. In the field of pharmaceutical synthesis, this is a key intermediate. The preparation of many drugs relies on it as a starting material, which can be converted into compounds with specific pharmacological activities through a series of chemical reactions. For example, in the development of anti-tumor drugs, its structure can be cleverly modified to combine with specific targets of tumor cells, thus exerting the effect of inhibiting tumor cell proliferation.
In the creation of pesticides, 2-amino-5-bromopyridine also shows important value. Based on it, new pesticide molecules can be constructed. Such pesticides may have highly effective poisoning effects on specific pests, or can regulate the growth and development of crops, improve the resistance of crops, such as enhancing their resistance to pests, diseases, drought, salinity and other adverse environments, and help agriculture to increase yield.
In the field of materials science, it is also involved. For the synthesis of some functional materials, 2-amino-5-bromopyridine can be introduced as a structural unit. The prepared materials may have unique electrical, optical or mechanical properties. For example, when used in organic Light Emitting Diode (OLED) materials, it may improve the luminous efficiency and stability of devices, contributing to the development of display technology.
And because of the presence of amino and bromine atoms, the molecule is endowed with rich reactivity checking points, chemists can according to different needs, through halogenation, alkylation, acylation and other reactions, its structure is derived, and then develop more compounds with unique properties and uses, which play an indispensable role in many fields.

2-% hydroxy-5-bromopyridine is an important intermediate in organic synthesis, and its synthesis methods are diverse. The following are common methods:
1. ** Halogenation method **:
- Using 2-hydroxypyridine as the starting material, bromine atoms are introduced by halogenation reaction. In a suitable solvent, such as dichloromethane, in the presence of a suitable catalyst, such as iron powder or iron tribromide, react with bromine. During the reaction, the reaction temperature and the amount of bromine must be strictly controlled to prevent the formation of polyhalogenated by-products. The advantage of this method is that the starting material is relatively easy to obtain, and the reaction conditions are relatively easy to control; the disadvantage is that there may be many side reactions, and the separation and purification of the product is slightly complicated.
- The reaction process is as follows: first dissolve 2-hydroxypyridine in dichloromethane, cool it to a certain temperature, slowly add the mixture of bromine and catalyst dropwise, add it dropwise, and heat it up to an appropriate temperature for several times. After that, the target product is obtained by means of washing, drying, and column chromatography.
2. ** Metal Catalytic Coupling Method **:
- A suitable halogenated pyridine derivative and a hydroxyl-containing reagent can be selected, and the coupling reaction is carried out under the action of a metal catalyst. For example, 5-bromopyridine halide and phenate are used as raw materials, and in the presence of metal catalysts and ligands such as palladium or nickel, they are reacted in a suitable base and solvent system. This method has high selectivity and can effectively construct the structure of the target product. However, the metal catalyst is more expensive, the reaction conditions are more harsh, and the reaction equipment and operation requirements are strict.
- During the specific operation, the halide, phenolic salt, metal catalyst, ligand and base are placed in a reaction kettle in a certain proportion, the inert gas is pumped out, and the reaction is carried out at a specific temperature and pressure. After the reaction, the product is purified by extraction, distillation and other steps.
3. ** Cyclization method **:
- The structure of 2-hydroxy-5-bromopyridine is constructed by means of intramolecular cyclization reaction. Using a chain compound containing appropriate functional groups as the starting material, a reasonable reaction route is designed to cyclize the molecule and introduce hydroxyl and bromine atoms. This method can construct the pyridine ring and the desired substituent in one step, and the atomic economy is good. However, the design and synthesis of starting materials are demanding, and the reaction route is usually lengthy. < Br > - For example, a chain-like precursor with a specific structure is synthesized first, and under appropriate reaction conditions, such as strong acid or base catalysis, heating, etc., the molecule is cyclized to generate the target product, which is then isolated and refined to obtain a pure product.

2-% amino-5-bromopyridine is an organic compound with unique physical and chemical properties and a wide range of uses in the chemical and pharmaceutical fields. The following details its properties:
1. ** Physical properties **:
- ** Appearance **: At room temperature, 2-amino-5-bromopyridine is mostly white to light yellow crystalline powder, which is easy to store and use. Some fine chemicals have strict appearance requirements, and this appearance characteristic of this compound meets the needs of many production scenarios.
- ** Melting point **: Melting point is between 145-148 ° C. Melting point is a key indicator for identification and purity determination, and accurate melting point data is helpful for quality control and product identification. In this melting point range, the substance will undergo a solid-to-liquid transition, providing a temperature basis for synthesis, purification and other processes.
- ** Solubility **: Slightly soluble in water, soluble in common organic solvents, such as ethanol, dichloromethane, etc. This solubility characteristic is of great significance in organic synthesis, and researchers can select suitable solvents for reaction and separation. For example, in a reaction system using ethanol as a solvent, 2-amino-5-bromopyridine can be fully contacted with other reactants to promote the reaction process.
2. ** Chemical properties **:
- ** Amino reaction **: Amino groups are basic and nucleophilic. The alkalinity allows it to react with acids to form salts, such as reacting with hydrochloric acid to form corresponding hydrochloric salts, which can improve drug solubility and stability in pharmaceutical preparations. Nucleophilicity allows it to act as a nucleophilic reagent in nucleophilic substitution reactions, attacking compounds containing active leaving groups, like reacting with halogenated hydrocarbons to form new nitrogen-containing organic compounds, providing a way for organic synthesis of new substances.
- ** Bromine atom reaction **: Bromine atom has high activity and can undergo a variety of reactions. Under metal catalysis, it can participate in coupling reactions, such as Suzuki coupling reaction, and aryl boric acid under the action of palladium catalyst to form biaryl compounds, which are widely used in drug and material synthesis to expand the structural complexity and functionality of compounds. < Br > - ** Reaction on ring **: The pyridine ring is aromatic and can undergo electrophilic substitution reaction. Due to the localization effect of amino and bromine atoms, electrophilic reagents mainly attack the specific position of the pyridine ring and synthesize pyridine derivatives with specific substitution modes to meet the needs of different fields for special structural compounds.

The price of 2-amino-5-bromopyridine varies from market to market due to various reasons. Its price often fluctuates within a certain range.
Looking at the source flow of various materials, if the various raw materials required are easy to harvest, widely available, and available to the market, the price of 2-amino-5-bromopyridine may flatten or decrease slightly. On the contrary, if the raw materials are rare, difficult to harvest, and in short supply, the price will rise.
It depends on the simplicity of the process. If the method of making this 2-amino-5-bromopyridine is simple and easy, requires less labor, and takes less time, the cost will drop, and the price will also drop. However, if the production method is complicated, requires exquisite equipment, many steps, and takes time and effort, the cost will increase, and the price will be high.
Again, discuss the supply and demand of the market. If the market wants a lot of 2-amino-5-bromopyridine, but there are few products, and the supply is in short supply, the price will be high. If the output is abundant, but there are few applicants, and the supply exceeds the demand, the price will fall.
Roughly speaking, in today's market, the price of 2-amino-5-bromopyridine may range from tens to hundreds of yuan per gram. However, this is only an approximate number, and the actual price often changes from time to time, varies from place to place, and varies with general market conditions. To know the exact price, it is also necessary to study the general market conditions and the pricing of the seller.

In the realm of Huaxia, those who are good at making 2-amino-5-nitropyridine have all kinds of talents.
In the land of the south of the Yangtze River, there is the Chen's workshop. The Chen family is proficient in alchemy techniques, and later transferred to the workshop to study physical properties. The elders of the family have studied classics since childhood and are well versed in the combination of gold, stone and grass. In the manufacture of 2-amino-5-nitropyridine, with a unique method, the best medicinal stones are selected. After multiple processing, the temperature is controlled and the temperature is subtle, so that the materials are delicately fused, and the products produced are of high quality.
In the Central Plains, the Li's Yaotang also has strengths. The Li family has practiced medicine for generations and is proficient in pharmacology. He made this pyridine according to the principles of medical science, based on natural medicinal materials, supplemented by clever skills. First grind all the medicines into the end, according to the order of five elements to generate grams, and then put them into a special pill furnace. Boil slowly with a slow fire, and promote change with a martial fire. The 2-amino-5-nitropyridine produced is pure and flawless, and it is very good for medical application.
In the land of Yan and Zhao, there is a workshop of the Zhang family. Everyone in the Zhang family is firm and good at studying. He made this thing, and it is ingenious to use heavy equipment. Special copper kettle and iron tripod, with precise measurement, put the materials into it. Use water power and wind to support combustion, and control the temperature between millimeters. After repeated trials, the pyridine produced is quite praised in the fields of equipment manufacturing, precision carving and other fields.
In the land of Bashu, the Zhao's workshop should not be underestimated. The Zhao family has lived in the mountains and rivers for a long time and is familiar with the local rare and exotic grass. It makes 2-amino-5-nitropyridine, making good use of local specialties, combined with family secret methods. Collecting spiritual grass in deep mountain valleys, it is compatible with all kinds of gold and stone, and refining in bamboo houses and firewood stoves with unique processes. The products produced contain the spiritual energy of mountains and rivers, which is wonderful in many fields.