2-Amino-5-chlorothiazole-4-carboxylic acid methyl ester

Methyl 2-amino-5-chlorothiazole-4-carboxylate has a wide range of uses. In the field of medicine, it is a key organic synthesis intermediate and often participates in the preparation of many drugs. The structure of the Geiinthiazole ring has unique biological activity in many drugs. 2-amino-5-chlorothiazole-4-carboxylic acid methyl ester is used as a building block. It can be combined with other functional groups through a series of chemical reactions to derive drug molecules with specific pharmacological effects. For example, in the development of antibacterial drugs, new drugs with inhibitory effects on specific pathogens can be prepared through multi-step reactions using this as a starting material.
In the field of pesticides, it also plays an important role. It can be used as an important intermediate for the synthesis of new pesticides. After chemical modification, pesticides can give pesticides such as insecticidal, bactericidal or weeding effects. Due to their structural characteristics, the synthesized pesticides may have high selectivity and high efficiency for target organisms, while having a small impact on the environment, which is in line with the current trend of green pesticide development.
In the field of materials science, 2-amino-5-chlorothiazole-4-carboxylate methyl ester has also shown potential uses. Through appropriate polymerization reactions or composites with other materials, functional materials with special properties, such as those with optical, electrical, or adsorption properties, can be prepared, providing new possibilities for innovative development in the field of materials science.

2-Amino-5-chlorothiazole-4-carboxylic acid methyl ester, is a kind of organic compound. Its physical properties are quite critical and it has a wide range of uses in chemical research and related fields.
Looking at its appearance, it is often white to off-white crystalline powder. This form makes it easy to handle and operate in many reactions and applications. Its melting point has a certain range, roughly within a specific temperature range. The characteristics of the melting point can help identify the purity of the substance. If the purity is high, the melting point is relatively stable and close to the theoretical value; if it contains impurities, the melting point may be offset.
Solubility is also an important physical property. This compound has a certain solubility in common organic solvents, such as ethanol, acetone, etc. In ethanol, under suitable temperature and conditions, it can be partially dissolved to form a uniform solution. In water, the solubility is relatively small. Such a difference in solubility provides a basis for the choice of separation, purification and reaction conditions.
Its density also has a specific value, which reflects the mass of the substance per unit volume. Knowing the density, when it involves measurement, mixing and other operations, it can accurately control the amount of each substance to ensure the accuracy of the experiment or production process.
In addition, the stability of the compound is also worthy of attention. Under normal temperature and pressure, it can maintain a relatively stable chemical structure and physical form for a certain period of time. However, in case of extreme conditions such as high temperature, strong acid, strong alkali, or chemical reactions, the structure changes and affects its original properties and functions.
In summary, the physical properties of methyl 2-amino-5-chlorothiazole-4-carboxylate, such as appearance, melting point, solubility, density and stability, are of great significance to its research, application and related process operations.

The synthesis method of 2-amino-5-chlorothiazole-4-carboxylic acid methyl ester has been used by many parties throughout the ages. One common method is to use chlorine-containing raw materials and reagents containing nitrogen, sulfur and other elements. Under specific reaction conditions, such as suitable temperature, pressure and catalyst action, the molecules interact to gradually build a thiazole ring, and then introduce amino and ester groups.
Or prepare a thiazole skeleton first, and then introduce chlorine atoms through a halogenation reaction, and then perform amination and esterification steps. When halogenating, choose the appropriate halogenation reagent and reaction environment to ensure that the chlorine atoms are accurately connected to the designated location. In the amination process, it is also necessary to pay attention to the selectivity and yield of the reaction, and choose suitable amination reagents and auxiliary agents to promote the reaction.
In the esterification reaction, according to the characteristics of the raw materials, select suitable alcohols and catalysts to control the reaction process and improve the purity and yield of the target product.
Another synthesis path is to start from the basic organic compound and gradually splice the required functional groups and skeletons through multi-step reactions. This process requires fine planning of the reaction sequence, consideration of the interaction between each step, and clever use of protection and deprotection strategies to achieve the purpose of efficient synthesis of 2-amino-5-chlorothiazole-4-carboxylate methyl ester. Each method has its own advantages and disadvantages, and it is necessary to make a careful choice based on factors such as the actual availability of raw materials, cost considerations, and product quality requirements.

In Wuguan City, the price of 2-amino-5-chlorothiazole-4-carboxylic acid methyl ester varies from time to time, and depends on changes in quality, supply and demand. In the past, the market conditions, its price fluctuations are quite large. At first, due to the lack of refinement of the process, the preparation is difficult, this product is scarce, and the price is as high as a thousand gold. At that time, the price per gram may exceed hundreds of gold.
After the skill is gradually refined, the production capacity is gradually increased, and the price is slightly reduced. In ordinary times, those with good quality may sell tens of gold per gram, and some may vary depending on the quantity. If you buy it in bulk, the price may be slightly reduced. However, if you are looking for a very pure product, the price is still not cheap, or nearly 100 gold per gram.
And due to changes in raw materials and the current situation, the price also fluctuates. When raw materials are scarce, or others are trapped due to production capacity, the price will rise. And different merchants have different prices due to cost and profit calculations. Therefore, the price range is about tens of gold per gram to hundreds of gold, and it is difficult to determine a certain number.

2-Amino-5-chlorothiazole-4-carboxylic acid methyl ester, this is an organic compound, and its Quality Standard is very important, which is related to product quality and application efficiency. The following are common Quality Standards:
1. ** Content Determination **: This is a key indicator, determined by high performance liquid chromatography (HPLC) method. Usually the content is not less than a specific value, such as 98.0%, or even higher. Accurate determination of content can confirm the purity of the product and the proportion of active ingredients, and ensure its stability and consistency in various reactions and applications. If the content is insufficient, the reaction yield may be reduced and the product performance may not meet expectations.
2. ** Appearance characteristics **: It should be white to off-white crystalline powder with uniform color and no obvious impurities and foreign matter. Appearance inspection is convenient and intuitive. If the color is abnormal or there are visible impurities, or it indicates that the product is contaminated or the purity is poor.
3. ** Melting point **: It has a specific melting point range and is generally determined by a melting point meter. The melting point can reflect the purity and crystalline structure of the substance. If the melting point deviates from the standard range, or it means that the product is impure and contains impurities that affect the crystallization performance.
4. ** Loss on drying **: It is designed to detect the content of moisture and volatile impurities in the product. Commonly used oven drying method or vacuum drying method, it is stipulated that the loss on drying shall not exceed a certain limit, such as 0.5% Excessive moisture and volatile impurities, or affect product stability, chemical reaction activity and storage life.
5. ** Heavy metal content **: need to be strictly controlled, such as lead, mercury, cadmium and other heavy metals. Because of its toxicity, even if a small amount of residue, when used in medicine, food-related fields, it may also endanger human health. Determination by atomic absorption spectroscopy (AAS) and other methods, the limit is often in parts per million (ppm) to ensure that the heavy metal content is extremely low.
6. ** Related substances **: Detection by HPLC and other methods is used to identify and quantify impurities that may exist in products, such as synthetic intermediates, by-products, etc. The limit of relevant substances is clearly stipulated to ensure product quality and safety. Excessive impurities can affect product performance, stability, or even introduce toxicity risks.