2-Amino-5-bromothiazole monohydrobromide

2-Amino-5-bromothiazole monohydrobromide has a wide range of uses. In the field of medicinal chemistry, it is a key intermediate in organic synthesis. In the process of drug development, this is the starting material, and through a series of chemical reactions, complex molecular structures with specific biological activities can be constructed. For example, in the development of antibacterial drugs, with the help of its unique chemical structure, it can interact with key targets in bacteria and interfere with the normal physiological activities of bacteria, thus achieving antibacterial effect.
In the field of materials science, it also shows unique functions. Because it contains special functional groups, it can participate in the surface modification reaction of materials. After specific treatment, a functional layer with specific properties is formed on the surface of the material, which improves the hydrophilicity, stain resistance or biocompatibility of the material. For example, in the field of biomedical materials, modification of the surface of implanted devices can reduce the immune rejection reaction of the body and improve the safety and effectiveness of the device.
Furthermore, in the study of organic synthetic chemistry, 2-amino-5-bromothiazole monohydrobromide is an important building block, participating in the construction of various organic compounds containing thiazole rings. Thiazole ring structures are widely found in natural products and bioactive molecules. By chemically modifying and transforming this substance, organic molecules with novel structures and unique properties can be synthesized, providing a material basis and research direction for new drug research and development, functional material creation, etc.

2-Amino-5-bromothiazole hydrobromide is a rather important chemical substance. Its physical properties, first of all, in terms of appearance, are often white to light yellow crystalline powders, delicate and uniform in quality, and pure in appearance.
As for the melting point, it has been determined by many experiments to be between 230-235 ° C. In this temperature range, the substance will gradually melt from solid to liquid state. This property is of key significance in chemical production and analysis and identification.
In terms of solubility, it shows a certain solubility in water and can be partially dissolved, making the solution slightly conductive. In organic solvents, such as methanol, ethanol and other polar organic solvents, the solubility is relatively better, and it can be dispersed more evenly to form a uniform and stable solution system. However, in non-polar organic solvents, such as n-hexane, benzene, etc., the solubility is very small, and it is difficult to dissolve and disperse.
In terms of stability, under conventional environmental conditions, it is quite stable and can be stored for a long time without significant chemical changes. However, it should be noted that it has certain sensitivity to light and heat. Long-term exposure to strong light or high temperature environment will accelerate its decomposition rate, cause structural changes, and then affect its chemical activity and application performance. Therefore, when storing, it should be placed in a cool, dry and dark place to ensure the stability of its quality and performance.

The synthesis method of 2-amino-5-bromothiazole hydrobromide is as follows.
First take an appropriate amount of 2-amino thiazole, place it in a clean reactor, cool it in an ice bath, and reduce the temperature in the kettle to about 0-5 ° C. Then, under stirring, slowly add the glacial acetic acid solution of bromine. The rate of dropwise addition must be properly controlled to avoid excessive reaction. After adding dropwise, keep stirring at low temperature for several hours to allow the reaction to proceed fully. At this time, signs of reaction such as color change can be observed in the kettle.
When the reaction reaches the desired level, remove the reaction mixture from the ice bath, let it naturally warm to room temperature, and then continue to stir for a period of time. Next, hydrobromic acid is added dropwise to it, and the dropwise addition process still needs to be stirred. After the reaction is completed, the resulting mixture is distilled under reduced pressure to remove the solvent and low boiling point impurities. Subsequently, an appropriate amount of organic solvent, such as ethanol or ether, is added to the residue for recrystallization. The mixture is heated to an appropriate temperature to fully dissolve the solids, and then slowly cooled to precipitate crystals. After the crystals are completely precipitated, suction filtration is carried out to obtain the crude product of 2-amino-5-bromothiazole hydrobromide.
Finally, the crude product is recrystallized with an appropriate solvent to obtain a relatively pure 2-amino-5-bromothiazole hydrobromide product. During the operation, attention should be paid to the control of temperature, dripping speed and reaction time at each step to ensure the smooth progress of the reaction and the purity and yield of the product.

2-Amino-5-bromothiazole monohydrobromide requires careful attention when storing and transporting. This is a chemical substance, which is active in nature. When stored, the temperature and humidity of the environment are the first priority. It should be placed in a cool, dry and well-ventilated place to prevent moisture deterioration and chemical properties from changing. If the cover temperature and humidity are too high, it may cause chemical reactions, which will damage its purity and quality.
Furthermore, this substance is sensitive to light, so it is necessary to avoid light. It should be stored in a container with shading to ensure its stability. When transporting, the packaging must be solid and reliable to prevent package damage and material leakage due to collision and vibration.
In addition, 2-amino-5-bromothiazole monohydrobromide may be toxic and corrosive. Operators and transportation personnel must wear professional protective equipment, such as gloves, goggles and protective clothing, to ensure their own safety and avoid contact with the skin and eyes. If they come into contact accidentally, they should rinse with plenty of water as soon as possible and seek medical attention in time.
At the same time, during transportation, strictly abide by relevant regulations and standards, properly label, and allow transportation personnel and regulators to clarify its characteristics and hazards for emergency response. In short, regardless of storage or transportation, fine operation and careful protection are required to ensure the safety and quality of 2-amino-5-bromothiazole monohydrobromide.

I look at your question, and I am inquiring about the market price of 2-amino-5-bromothiazole monohydrobromide. However, the price of this chemical often changes due to various factors, and it is difficult to be sure.
First, the price of raw materials has a great impact. The prices of various raw materials required for the preparation of this chemical may fluctuate due to changes in origin, season, and supply and demand. If raw materials are scarce or costs rise, the price of this chemical will also rise.
Second, the simplicity of the production process is related to cost. Complex and high-cost processes will inevitably increase the price of the product; while simple and efficient methods may reduce the price slightly.
Third, the market supply and demand situation is the key. If the demand is strong and the supply is limited, the price will rise; if the supply exceeds the demand, the price will decline.
Fourth, the quality level also affects the price. High purity, high quality, the price must be higher than the ordinary level.
Furthermore, the sales area, purchase quantity, etc. also have an impact. Prices vary in different regions, and there may be discounts for large purchases.
According to the concept of "Tiangong Kaiwu", all things in the world have a price due to the cost of labor, raw materials, etc. However, the price of 2-amino-5-bromothiazole monohydrobromide is difficult to explain, and it is necessary to carefully observe the market conditions and negotiate with suppliers to obtain a more accurate price.