2-Amino-5-bromothiazole hydrobromide

2-Amino-5-bromothiazole hydrobromide has a wide range of uses. In the field of medicine, it is a key intermediate and helps to synthesize a variety of specific drugs. The unique structure of the Gainthiazole ring gives drugs a variety of biological activities, such as antibacterial, antiviral, and anti-tumor. Taking some antibacterial drugs as an example, 2-amino-5-bromothiazole hydrobromide participates in the construction of the core structure of the drug, enhances the affinity between the drug and the bacterial target, and enhances the antibacterial efficacy.
In the field of pesticides, it also plays an important role. It can be used to create new pesticides, and its structural properties can be used to highly selectively inhibit or kill specific pests or pathogens. For example, some pesticides, with the help of this compound, optimize the molecular structure, improve the effect on the nervous or physiological system of pests, and have a small impact on the environment, which meets the requirements of modern pesticides for high efficiency, low toxicity and environmental protection.
In addition, in the field of organic synthesis, it is often used as a starting material or a key intermediate. Because of its active functional groups, it can participate in many organic reactions, such as substitution reactions, condensation reactions, etc., providing the possibility to construct complex organic molecular structures and assisting in the synthesis of organic materials with specific functions, making significant contributions to the frontier research and application expansion of materials science.

The synthesis method of 2-amino-5-bromothiazole hydrobromide has been different in ancient times, and this is a detailed description for you.
One method is to use 2-amino thiazole as the starting material to interact with brominating reagents such as liquid bromine and N-bromosuccinimide (NBS). When using liquid bromine as a brominating agent, liquid bromine must be slowly added dropwise in a low temperature, inert solvent such as dichloromethane. In this process, liquid bromine and 2-aminothiazole undergo electrophilic substitution reaction, and the bromine atom preferentially falls at the 5-position of the thiazole ring, thereby generating 2-amino-5-bromothiazole. Subsequently, 2-amino-5-bromothiazole is mixed with hydrobromic acid and reacted at an appropriate temperature to obtain 2-amino-5-bromothiazole hydrobromide.
The second method uses suitable sulfur-containing and nitrogen-containing compounds as raw materials to construct thiazole rings through multi-step reactions. For example, α-halogenated ketone and thiourea are used as the starting materials to cyclize to form thiazole compounds, and then the bromination step is carried out. During cyclization, the halogen atom of α-halogenated ketone and the amino and mercapto groups of thiourea are condensed and cyclized to form a thiazole ring skeleton. After that, with the aforementioned bromination method, a 5-position bromine atom is introduced, and finally it is reacted with hydrobromic acid to form a salt.
The third method is a coupling reaction catalyzed by transition metals. Select suitable halogenated thiazole derivatives, and amino-containing reagents, under the synergistic action of transition metal catalysts such as palladium and copper and ligands, to introduce amino groups to obtain 2-amino-5-bromothiazole, and then salt with hydrobromic acid. This method has mild conditions and good selectivity, but the catalyst is expensive or increases the cost.
All these synthesis methods have advantages and disadvantages. According to actual needs, consider the availability of raw materials, the difficulty of reaction, the high cost and other factors, and choose carefully to obtain satisfactory results.

2-Amino-5-bromothiazole hydrobromide is one of the organic compounds. Its physical and chemical properties are quite worthy of detailed investigation.
In terms of its physical properties, under room temperature, this compound is mostly in a solid state. Looking at its color, it is often white to off-white powder, which is easy to identify and observe. Its texture is delicate, and it feels different from others. And this substance is relatively stable in the air, but it also needs to be properly stored to avoid environmental factors.
As for its solubility, it shows unique characteristics in specific solvents. In polar solvents such as water, it has a certain solubility, but its solubility is not very high. In organic solvents, such as ethanol and dichloromethane, the solubility varies slightly, depending on the polarity of the solvent and the intermolecular forces. The characteristics of this solubility are of great significance for their separation, purification and application in chemical reactions.
From a chemical perspective, the amino groups and thiazole rings in the molecule of 2-amino-5-bromothiazole hydrobromide give it unique reactivity. Amino groups are nucleophilic and can participate in many nucleophilic substitution reactions. They react with electrophilic reagents such as halogenated hydrocarbons and acid anhydrides to form new chemical bonds, thereby constructing more complex organic molecular structures. The presence of the thiazole ring also affects the electron cloud distribution of the molecule, making its chemical properties more abundant. The hydrobromate part, under appropriate conditions, can dissociate, releasing bromine ions and protons, and this process affects the rate and direction of the chemical reactions it participates in. And the compound is quite sensitive to acid-base environment, and its chemical behavior is also different in different pH media. In case of strong acid and alkali, proton transfer, hydrolysis and other reactions may occur, thereby changing its chemical structure and properties.

2-Amino-5-bromothiazole hydrobromide is a chemical substance. When storing and transporting, the following matters must be paid attention to:
First, the storage environment is the most critical. This substance should be stored in a cool, dry and well-ventilated place. High temperature and humid environment can easily cause its properties to change. If placed in a high temperature environment, it may cause chemical reactions such as decomposition; while humid environment may cause it to absorb moisture and deteriorate, thus affecting its quality and use efficiency.
Second, the packaging must be tight. Packaging materials with good sealing performance must be used to prevent contact with air, moisture, etc. Damaged packaging can easily cause the substance to be disturbed by external factors and cause its chemical properties to change.
Third, during transportation, avoid violent vibrations and collisions. Because it is a chemical product, violent vibrations or collisions may cause packaging damage, and may also cause physical or chemical reactions of internal substances, endangering transportation safety.
Fourth, it needs to be isolated from other chemicals. 2-Amino-5-bromothiazole hydrobromide may react with certain chemicals, so when storing and transporting, do not mix with chemicals that are contrary to their nature, to prevent accidents.
Fifth, be sure to strictly follow relevant regulations and operating procedures. Whether it is storage or transportation, it should comply with the safety standards and norms formulated by the state and the industry. Operators must also be familiar with the operation process to ensure proper operation and eliminate potential safety hazards.

I look at your question, but I am inquiring about the market price of 2-amino-5-bromothiazole hydrobromide. However, the price of this chemical often varies depending on factors such as time, place, quality, supply and demand, and it is difficult to determine the exact value.
In the past, when "Tiangong Kaiwu" was written, although this chemical was not involved, it can be deduced according to common sense. If there is a situation of supply and demand in the market, if the demand for this product is strong and the supply is scarce, the price will be higher; on the contrary, if the supply exceeds the demand, the price will be lower.
And quality is also the main factor. The price of high-purity 2-amino-5-bromothiazole hydrobromide must be higher than that of ordinary ones. And the region is different, in the bustling place, the transportation is convenient, the logistics cost is low, and the price is different from the remote place.
Furthermore, the market fluctuates, the price of today may change tomorrow. Or due to the rise and fall of raw material prices, the improvement of production processes, the adjustment of policies and regulations, etc., the price can fluctuate. Therefore, if you want to know the exact market price, you should consult chemical raw material distributors, trading platforms, or visit the chemical market to get near real-time price information.