2-AMINO-4-FLUOROBENZOTHIAZOLE

2-Amino-4-fluorobenzothiazole is one of the organic compounds. It has a wide range of uses in the field of medicine and can be used as a key intermediate in drug synthesis. The structure of Geiinbenzothiazole gives it unique biological activity. By introducing amino and fluorine atoms, it can optimize the pharmacological properties of compounds, such as improving the affinity and selectivity of drugs to specific targets, and helping to create new specific drugs, such as antibacterial and anti-tumor.
In the field of materials science, this compound also has important uses. Due to its special electronic structure and chemical stability, it can be used to prepare functional materials, such as optoelectronic materials. In organic electroluminescent devices, 2-amino-4-fluorobenzothiazole can be used as a component of the luminescent layer material. With its luminescent characteristics, it can improve the luminous efficiency and color purity of the device, and contribute to the development of display technology.
In addition, in the field of agricultural chemistry, it may be used as a raw material for pesticide synthesis. Using its chemical properties to develop pesticides with high insecticidal and bactericidal properties, it can not only effectively control crop diseases and pests, but also reduce the adverse impact on the environment, which is in line with the development needs of green agriculture. In short, 2-amino-4-fluorobenzothiazole plays an indispensable role in many fields and is of great significance to promote the progress of related industries.

2-Amino-4-fluorobenzothiazole is one of the organic compounds. It has unique physical properties, so let me tell you one by one.
When it comes to appearance, it is often a white-like to light yellow crystalline powder, delicate and with a specific crystal structure. This appearance characteristic is quite important when identifying and preliminarily determining its purity.
Looking at its melting point, it is about [X] ° C. The melting point is one of the important physical constants of a substance. Accurate determination of the melting point can help confirm the purity and authenticity of the compound. If the melting point of the sample matches the values recorded in the literature and the melting range is narrow, it indicates that its purity is high; conversely, if the melting range is wide, it may contain impurities. In terms of solubility, it has a certain solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), etc. In dichloromethane, with proper stirring and heating, it can be better dissolved to form a homogeneous solution; in DMF, the solubility is better, because its strong polarity can interact with 2-amino-4-fluorobenzothiazole molecules to help them disperse. However, its solubility in water is very small. Due to the existence of benzothiazole rings, amino groups and fluorine atoms in its molecular structure, its overall polarity is not enough to form an effective interaction with water molecules, so it is difficult to dissolve in water.
In addition, the density of 2-amino-4-fluorobenzothiazole is about [X] g/cm ³. Although this physical property is not often directly used in routine analysis, it may be of great significance in some specific fields, such as in density-related separation and mixing operations.
In summary, the physical properties of 2-amino-4-fluorobenzothiazole are diverse. In the fields of organic synthesis and drug development, understanding and making good use of these properties is of great significance for the effective preparation, separation and application of this compound.

The synthesis methods of 2-amino-4-fluorobenzothiazole have existed in ancient times, and there are many kinds. The main ones are selected and described as follows.
First, o-amino thiophenol and fluorocyanobenzene are used as starting materials. First, the o-amino thiophenol reacts with an appropriate base to generate a corresponding salt to enhance its nucleophilicity. Then, the salt is mixed with fluorocyanobenzene, in a suitable solvent, and heated to reflux. During this process, nucleophilic substitution reactions occur gradually, and sulfur atoms attack the cyanobenzene of fluorocyanobenzene. After cyclization and rearrangement, 2-amino-4-fluorobenzothiazole is finally obtained. In the meantime, the choice of solvent is very critical. Common polar aprotic solvents such as N, N-dimethylformamide (DMF) and dimethyl sulfoxide (DMSO) can promote the reaction.
Second, 2-halo-4-fluoroaniline and thioformamide are used as raw materials. First, 2-halo-4-fluoroaniline and thioformamide are mixed under alkaline conditions. Potassium carbonate, sodium carbonate, etc. can be selected for the base. Under heating conditions, the halogen atom is replaced by the sulfur atom of thioformamide, and then the molecular ring is formed to form the target product. This reaction requires attention to the control of reaction temperature and time. If the temperature is too high or the time is too long, it may cause side reactions and reduce the purity of the product.
Third, 4-fluoro-2-nitroaniline is used as the starting material. First, it is reduced to 4-fluoro-2-aminoaniline. The commonly used reducing agents are iron filings and hydrochloric acid, hydrogen and palladium carbon. Then, 4-fluoro-2-aminoaniline reacts with carbon disulfide in an alkaline environment to form thiocarbamate intermediates, which are then cyclized and dehydrated to obtain 2-amino-4-fluorobenzothiazole. This synthesis path has a little more steps, but the raw materials are easy to obtain, and it is also a commonly used method.
All synthesis methods have their own advantages and disadvantages, and need to be carefully selected according to actual needs, such as the availability of raw materials, cost, product purity and other factors.

In today's world, business conditions change, and it is not easy to know the price of 2 - AMINO - 4 - FLUOROBENZOTHIAZOLE in the market. The price of covering it often changes due to many reasons, such as the abundance of raw materials, the difficulty of making art, the amount of need, and the rise and fall of market conditions.
In the past, the price of chemical products always moved according to the law of supply and demand. If there are many people who need this product, but there are few who produce it, the price will rise; if the supply exceeds the demand, the price will drop. And the price of raw materials is also the key. If the raw materials are rare and the price is high, the price of 2 - AMINO - 4 - FLUOROBENZOTHIAZOLE will also rise. < Br >
However, in today's market, the situation is unpredictable. Although there is no definite number to state the price of this thing, it can be pushed. If in ordinary times, the supply and demand are slightly flat, and the process does not change greatly, the price may be stable within a certain range. However, if there is a shortage of raw materials, or the process is difficult, resulting in a reduction in production, the price may increase. Conversely, if the production capacity increases greatly and the demand remains unchanged, the price may decrease.
The distance of the city and the convenience of transportation also affect the price. In nearby cities, the price may be slightly lower due to the cost of freight; in distant cities, the price may be slightly higher due to the cost and profit. And different businesses sell at different prices due to their different cost and profit calculations. < Br >
It is necessary to determine the price of Ximing 2 - AMINO - 4 - FLUOROBENZOTHIAZOLE. It is necessary to carefully consider the raw materials, production capacity, demand, and geographical matters in order to obtain a more accurate number. However, the market is unstable, and the price is also difficult to determine. It can only be speculated according to the situation.

2-Amino-4-fluorobenzothiazole is a crucial chemical intermediate in the field of organic synthesis and is widely used in the pharmaceutical, pesticide, dye and other industries. Today, many manufacturers are involved in the production of this compound.
In China, there are many large-scale chemical companies focusing on its production. For example, a chemical enterprise in Jiangsu, with its own advanced production process and strict quality control system, produces 2-amino-4-fluorobenzothiazole with high quality and has a good reputation in the market. It not only meets the needs of many domestic enterprises, but also is exported overseas.
There is also a chemical factory in Shandong, which has long been committed to the research and development and production of fine chemicals. The production process of 2-amino-4-fluorobenzothiazole is continuously optimized to improve product purity and reduce production costs, thereby enhancing its competitiveness in the market.
There are also well-known companies producing this product abroad. A chemical company in the United States has a deep foundation in the field of organic synthesis. It invests a lot of resources in the research and development and production of 2-amino-4-fluorobenzothiazole, and the quality of its products is excellent. It occupies an important share in the global market.
A German chemical giant, with its advanced technology and complete industrial chain, has also achieved remarkable results in the production of 2-amino-4-fluorobenzothiazole, and its products are widely used in high-end pharmaceutical and fine chemical fields.
In summary, many domestic and foreign manufacturers have continuously improved their technical level and product quality to meet the growing market demand for 2-amino-4-fluorobenzothiazole.