2-Amino-4,6-difluorobenzothiazole

2-Amino-4,6-difluorobenzothiazole is an organic compound with a wide range of uses in the chemical and pharmaceutical fields.
Its primary use lies in the creation of medicine. Because of its specific chemical structure and biological activity, it can serve as an intermediate for drug synthesis. For example, based on this, chemists can carefully construct molecules with unique pharmacological properties, which are expected to be used to develop new antibacterial and antiviral drugs. This is because benzothiazole compounds often have good biological activity, and the amino and fluorine atoms can modify their activity and drug metabolism characteristics, improve drug efficacy and reduce adverse reactions.
In the field of pesticides, 2-amino-4,6-difluorobenzothiazole is also highly valued. It can be chemically converted to produce pesticides that have high-efficiency killing or inhibitory effects on pests. Because of its structure, it can specifically act on the physiological processes of pests, such as interfering with the pest's nervous system or hindering its growth and development, thereby achieving good insecticidal effect, and is relatively friendly to the environment, with low residues.
Furthermore, it is also useful in the field of materials science. It can be used as a key raw material for the synthesis of functional materials, giving materials specific optical and electrical properties. For example, it is used to prepare organic Light Emitting Diode (OLED) materials, which can achieve high-efficiency luminescence and improve display performance due to their special molecular structure; or it is used to prepare sensor materials with high sensitivity and selectivity to specific substances, through its interaction with the target, to achieve accurate detection of trace substances in the environment and biological systems.

To prepare 2-amino-4,6-difluorobenzothiazole, there are various methods. One can start with 4,6-difluoro-2-nitrothiophenol, reduce it to 4,6-difluoro-2-aminothiophenol, and then cyclize it. This reduction method can be obtained by reacting with reducing agents such as iron powder, zinc powder or sodium sulfide in a suitable solvent. When cyclizing, it is often catalyzed by acids.
Second, 2-halo-4,6-difluoroaniline can be used to react with carbon disulfide in the presence of a base to form an intermediate, and then obtained by cyclization, desulfurization and other steps. The alkali can be selected from sodium hydroxide, potassium hydroxide, etc., and the reaction temperature and time need to be adjusted appropriately.
Third, with 4,6-difluorobenzoic acid as the starting material, it is first converted into the corresponding acid chloride, and then reacted with thiourea, and then the target product is prepared by cyclization and other operations. In the preparation of acid chloride, reagents such as thionyl chloride are commonly used, and the reaction conditions should be precisely controlled.
All these methods have their own strengths and weaknesses. The difficulty of operation, the cost, and the yield all need to be considered. When choosing the method, it should be determined according to the actual needs, the convenience of materials, and the suitability of conditions.

2-Amino-4,6-difluorobenzothiazole is a kind of organic compound. Its physical and chemical properties are quite important and are involved in the fields of chemical industry and scientific research.
In terms of its physical properties, under normal temperature and pressure, this substance is usually in solid form. Determination of its melting point is essential for identifying and purifying this compound. Generally speaking, accurate determination of the melting point can help confirm its purity. If it contains impurities, the melting point will often change. In addition, its appearance is often white to light yellow powder, with fine texture and visible. Looking at its solubility, in common organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), etc., it shows a certain solubility, but the solubility in water is relatively low. This solubility characteristic plays a key role in its synthesis, separation and application, and determines the choice of reaction medium and subsequent separation methods.
As for chemical properties, the amino group of 2-amino-4,6-difluorobenzothiazole and the fluorine atom on the benzothiazole ring give it unique reactivity. Amino groups are nucleophilic and can participate in a variety of nucleophilic substitution reactions, such as reacting with acyl halides, halogenated hydrocarbons, etc., to form various derivatives. The fluorine atom on the benzothiazole ring has certain stability, but under specific conditions, such as strong nucleophiles and suitable reaction temperature and pressure, substitution reactions can also occur, thus expanding the chemical derivatization path of this compound. In addition, because of its nitrogen-containing heterocyclic structure, protonation or deprotonation reactions may occur under acidic or basic conditions, which plays a role in its stability and reactivity in different acid-base environments.
The physical and chemical properties of this compound lay the foundation for its application in many fields such as medicinal chemistry and materials science. With its reactivity and solubility characteristics, researchers can modify and derive its structure to create new materials or new drug molecules with specific functions.

Today I have a question, what is the price range of 2-amino-4,6-difluorobenzothiazole in the market. This is a specific compound in the field of fine chemicals, and its price varies due to many factors, making it difficult to directly state the exact number.
First, purity is the key factor. If the purity is extremely high, reaching scientific research grade, almost 99% or more, because the preparation requires high-end technology and complicated processes, the cost is high, and the price must be high. However, if it is only industrial grade, the purity is slightly lower, and the price may drop significantly.
Second, the market supply and demand situation has a great impact. If the demand is strong, such as pharmaceutical synthesis and other fields are in urgent need, but the supply is limited, the price will rise. On the contrary, if the supply exceeds the demand, the price will fall.
Third, the production scale is also related. In large-scale production, due to the scale effect, the unit cost is reduced, and the price may tend to be flat. Small-scale production has high cost and high price.
Fourth, the fluctuation of raw material prices, the rise and fall of raw material prices for the preparation of 2-amino-4,6-difluorobenzothiazole, will directly transmit to the product price.
Overall, the price range is relatively large. In the market, low-end industrial grade, per kilogram or hundreds of yuan; high-end scientific research grade, per gram or tens of yuan or even higher, it is difficult to generalize, and it needs to be reviewed in detail according to specific quality, supply and demand.

2-Amino-4,6-difluorobenzothiazole is a crucial fine chemical in the field of organic synthesis, and is widely used in many fields such as medicine, pesticides, and materials. As for its manufacturers, with the booming development of my country's chemical industry, many manufacturers are involved in the manufacture of such products.
In northern my country, there is a large-scale chemical enterprise. It adheres to the concept of excellence, focuses on the production of 2-amino-4,6-difluorobenzothiazole with advanced production technology and strict quality control system. With years of accumulated experience, this factory produces high-quality products and has a good reputation in the industry. It is exported to many places in China, and some products are also involved in overseas markets.
There is also no shortage of such manufacturers in the south. There is an enterprise that continuously optimizes and upgrades its production technology with its profound scientific research heritage. The enterprise focuses on green production, and tries its best to reduce the impact of the production process on the environment while ensuring product quality. The 2-amino-4,6-difluorobenzothiazole it produces has excellent performance in purity and performance, and is favored by customers. It occupies a certain share of the high-end market.
In addition, there are also a number of manufacturers focusing on fine chemicals in East China involved in the production of this product. They meet the needs of different customers with flexible market strategies and efficient production models. Either provide customized services for small and medium-sized customers, or provide stable supply products for large enterprises to find their own foothold in the market competition. The joint efforts of these manufacturers promote the sustainable development of the 2-amino-4,6-difluorobenzothiazole industry.