What is the chemical structure of 2- ((6-chloro-2-methylpyrimidine-4-yl) amino) -N- (2-chloro-6-methylphenyl) thiazole-5-formamide?

2-%28%286-%E6%B0%AF-2-%E7%94%B2%E5%9F%BA%E5%98%A7%E5%95%B6-4-%E5%9F%BA%29%E6%B0%A8%E5%9F%BA%29-N-%282-%E6%B0%AF-6-%E7%94%B2%E5%9F%BA%E8%8B%AF%E5%9F%BA%29%E5%99%BB%E5%94%91-5-%E7%94%B2%E9%85%B0%E8%83%BA%E7%9A%84%E5%8C%96%E5%AD%A6%E7%BB%93%E6%9E%84%E6%98%AF%E6%80%8E%E6%A0%B7%E7%9A%84%EF%BC%9F%3F%2C the description of this chemical structure is more complicated and the expression is not standardized enough, it is analyzed by the method of ancient classical Chinese, or there is something unattainable, and I also look forward to Haihan.

Looking at this, it is to explore the structure of a specific chemical substance. Many groups are mentioned here, such as "methyl" and "amino", which are combined to form this compound. However, due to the complexity of the expression and the lack of chemical nomenclature, it is not easy to draw its structure accurately.

If it is common sense, according to the drawing rules of the chemical structure, the carbon chain is the bone, and each group is the branch, and the order of its connection is arranged. However, the information given in the text shows that the arrangement and connection relationship of the groups are slightly disordered. " 6-Alkane-2-methylpyridine-4-yl "and other expressions, if you want to build a structure, you need to determine the main chain. If this" alkane "is a carbon chain main chain, when its carbon number and configuration are known," 2-methylpyridine-4-yl "should be connected to the specific position of the alkane chain." 2-alkane-6-methylbenzyl "also needs to clarify its connection check point.

And the" 2 -%28%286-%E6%B0%AF-2-%E7%94%B2%E5%9F%BA%E5%98%A7%E5%95%B6-4-%E5%9F%BA%29%E6%B0%A8%E5%9F%BA%29 "part of the text, the" amino "connection structure is complex, and the connection logic of each part needs to be analyzed in detail.

I tried my best to analyze it in classical Chinese. Due to the complexity and irregularity of the original expression, it is difficult to give the exact chemical structure of 5-methylindole. To obtain the exact structure, it is necessary to rearrange the connection relationship of each group according to the chemical nomenclature, and express it in clear diagrams or accurate chemical language.

What are the main uses of 2- ((6-chloro-2-methylpyrimidine-4-yl) amino) -N- (2-chloro-6-methylphenyl) thiazole-5-formamide?

2-%28%286-%E6%B0%AF-2-%E7%94%B2%E5%9F%BA%E5%98%A7%E5%95%B6-4-%E5%9F%BA%29%E6%B0%A8%E5%9F%BA%29-N-%282-%E6%B0%AF-6-%E7%94%B2%E5%9F%BA%E8%8B%AF%E5%9F%BA%29%E5%99%BB%E5%94%91-5-%E7%94%B2%E9%85%B0%E8%83%BA%E7%9A%84%E5%85%A8%E7%A7%B0%E6%98%AF2 - ((6-cyanogen-2-methylpyrrole-4-yl) amino) -N - (2-cyanogen-6-methylbenzyl) -5 -methylnicotinamide. The main uses of this substance are as follows:

In the field of medicinal chemistry, it is often used as a potential drug intermediate. Due to its unique chemical structure, it provides a key starting framework for the development of new drugs. Based on this structure, researchers can modify different substituents and change their pharmacological activities to explore drugs with specific therapeutic effects. For example, for some inflammation-related diseases, drug molecules with targeted anti-inflammatory effects have been developed through structural modification of the compound.

In organic synthesis research, as an important synthetic building block. Due to the existence of various active groups in its structure, it can participate in a variety of organic reactions, such as nucleophilic substitution reactions, coupling reactions, etc., and then construct more complex organic compounds, expand the structural diversity of organic molecules, and promote the development of organic synthesis chemistry.

In materials science, it also shows potential application value. After appropriate modification, it may have special optical, electrical or thermal properties, which can be used to prepare functional materials, such as organic semiconductor materials used in optoelectronic devices, opening up new research directions and application possibilities in the field of materials science.

What are the synthesis methods of 2- ((6-chloro-2-methylpyrimidine-4-yl) amino) -N- (2-chloro-6-methylphenyl) thiazole-5-formamide?

To prepare 2 - ((6 - chloro - 2 - methylpyridine - 4 - yl) amino) - N - (2 - chloro - 6 - methylbenzyl) acetamide and 5 - methylindolone, the synthesis method is as follows:

###1, 2 - ((6 - chloro - 2 - methylpyridine - 4 - yl) amino) - N - (2 - chloro - 6 - methylbenzyl) acetamide
1. ** Preparation of starting materials **: Prepare starting materials such as 6-chloro-2-methylpyridine-4-amine and 2-chloro-6-methylbenzyl chloride. These two need to ensure high purity to facilitate the smooth progress of the reaction. 6-chloro-2-methylpyridine-4-amine can be prepared from the corresponding pyridine derivatives through multi-step reactions. The reaction process needs to be controlled by conditions to prevent side reactions. 2-chloro-6-methylbenzyl chloride also needs to be properly halogenated and prepared from 2-chloro-6-methyltoluene.
2. ** Condensation Reaction **: Place 6-chloro-2-methylpyridine-4-amine and 2-chloro-6-methylbenzyl chloride in a suitable organic solvent, such as N, N-dimethylformamide (DMF), and add an appropriate amount of base, such as potassium carbonate. The base can promote the nucleophilic substitution reaction. Warm up to an appropriate temperature, such as 80-100 ° C, and stir the reaction for several hours. In this process, the amino group of 6-chloro-2-methylpyridine-4-amine undergoes nucleophilic substitution to the benzyl chloride of 2-chloro-6-methylbenzyl chloride to form the intermediate.
3. ** Acetylation reaction **: After the intermediate is separated and purified, it is placed in the reaction system, and acetic anhydride or acetyl chloride is added as the acetylation reagent. An appropriate amount of organic base, such as triethylamine, is catalyzed. The amino group of the intermediate was acetylated at room temperature to 50 ° C for several hours to obtain the target product 2- ((6-chloro-2-methylpyridine-4-yl) amino) -N - (2-chloro-6-methylbenzyl) acetamide. The product was further purified by recrystallization, column chromatography, etc.

Synthesis of ###bis, 5-methylindolone
1. ** O-methylaniline method **
- ** Condensation of o-methylaniline and pyruvate **: Using o-methylaniline and pyruvate as the starting material, under acid catalysis, such as p-toluenesulfonic acid, in a suitable organic solvent, such as toluene, the reaction is heated and refluxed. The amino group of o-methylaniline undergoes a condensation reaction with the carbonyl group of pyruvate to form an enamine intermediate.
- ** Cyclization reaction **: The enamine intermediate is not separated, but directly undergoes an intramolecular cyclization reaction at high temperature or under the action of a specific catalyst. An appropriate amount of Lewis acid, such as ZnCl ², can be added to promote cyclization. After several hours of reaction, 5-methylindolone is obtained. The product is purified by distil
2. ** o-nitrotoluene method **
- ** o-nitrotoluene reduction **: o-nitrotoluene is reduced to amino group by iron powder, hydrochloric acid or catalytic hydrogenation, etc., to obtain o-methylaniline.
- ** Follow-up reaction is the same as o-methylaniline method **: The obtained o-methylaniline is then condensed and cyclized with pyruvate to obtain 5-methylindolone, and the steps are consistent with the order of o-methylaniline method.

During the synthesis process, each step of the reaction needs to strictly control the reaction conditions, including temperature, time, and the proportion of reactants, etc., in order to improve the yield and purity. And the product needs to be characterized by various analytical methods, such as nuclear magnetic resonance, mass spectrometry, etc., to confirm the structure.

What are the physical properties of 2- ((6-chloro-2-methylpyrimidine-4-yl) amino) -N- (2-chloro-6-methylphenyl) thiazole-5-formamide?

5-Ethylheptanal, its chemical name is not common, but in the field of chemistry, it also has its own unique characteristics. This substance is mostly colorless to light yellow liquid, and under normal temperature and pressure, it has a special smell, just like many aldehyde substances, exudes a rather special and irritating atmosphere.

Looking at its physical properties, the boiling point is a specific value, about [X] ° C, this temperature determines the conditions under which it converts from liquid to gaseous. The melting point is about [Y] ° C, which is the critical temperature for it to change from solid to liquid. Compared with water, the relative density has a specific ratio, about [Z], indicating that it is under the same volume and the difference between water mass.

Furthermore, its solubility is also characteristic, slightly soluble in water, but better soluble in organic solvents such as ethanol and ether. This property is closely related to the groups contained in the molecular structure. The presence of aldehyde groups makes the molecule have a certain polarity, but the long chain of ethyl groups reduces its affinity with water, so it is so soluble.

In addition, the volatility of 5-ethylheptanal is also worth noting. It can evaporate slowly in the air, which allows its odor to spread within a certain range. When storing, it should be sealed to prevent volatile loss, and because it is irritating, it is also necessary to avoid direct contact with the skin and eyes to prevent damage.

What are the market prospects for 2- ((6-chloro-2-methylpyrimidine-4-yl) amino) -N- (2-chloro-6-methylphenyl) thiazole-5-formamide?

The market prospect of 5-ethyl-2 - ((6-methoxy-2-methylbenzoyl) -4-yl) amino-N - (2-methoxy-6-methylbenzyl) benzamide-2-methylpyridine is related to many aspects.

Looking at its medicinal field, the current medical research and development, targeted precision therapy is the general trend. If this compound has unique pharmacological activity, it may be able to target specific disease targets. For example, in the fields of cancer and nervous system diseases, there is a thirst for new specific drugs. If this substance is experimentally verified, it can effectively act on key proteins or signaling pathways of related diseases, which is of great significance for clinical treatment. For example, some organic compounds containing special substituents in the past have been successfully converted into new anti-cancer drugs due to their ability to precisely regulate intracellular signaling, opening up a broad market.

Looking at the chemical synthesis level, its structure is complex, and its synthesis may pose challenges. However, with the advance of science and technology, new synthesis technologies and catalysts continue to emerge. If we can develop efficient synthesis routes, increase productivity and reduce costs, it will effectively promote its industrialization. For example, in the past, some complex organic molecules were prepared on a large scale with the help of new catalytic systems, thus causing the cost of related products to drop sharply and opening up market sales.

From the perspective of market competition, looking around congeneric products, if their performance is outstanding, such as better curative effect and fewer side effects, they can stand out. In the current market, various pharmaceutical companies compete fiercely, and innovative products are fundamental. If this compound has advantages, it may be able to get a share of the market.

But challenges cannot be ignored. Regulations and regulations are increasingly stringent, and the approval process for new drugs is long and complicated. If this compound is to be marketed, it needs to undergo multiple rounds of rigorous tests to ensure safety and effectiveness. Only by passing through many barriers can it win market recognition. In summary, 5-ethyl-2- ((6-methoxy-2-methylbenzoyl) -4-yl) amino-N - (2-methoxy-6-methylbenzyl) benzamide-2-methylpyridine market prospects, opportunities and challenges coexist, the key lies in R & D breakthroughs and compliance promotion.