2,5-Dichlorobenzo[d]thiazole

2% 2C5 -difluorobenzo [d] thiazole is an important intermediate in the field of organic synthesis and has a wide range of uses.
First, in the field of medicinal chemistry, it is often used to create new antibacterial drugs. Due to its unique chemical structure, it can precisely bind to specific bacterial targets and effectively inhibit bacterial growth and reproduction. For example, a research team introduced it into the drug molecular skeleton through a series of reactions and successfully developed new compounds with high antibacterial activity against drug-resistant bacteria, providing new ideas for solving clinical drug resistance problems.
Second, in pesticide chemistry, it can be used to synthesize high-efficiency and low-toxicity insecticides. With the help of its structural characteristics, the new insecticides designed and synthesized can specifically act on the pest nervous system, interfere with nerve conduction, cause pest paralysis and death, and have little impact on the environment and non-target organisms, which is in line with the development trend of green pesticides.
Third, in the field of materials science, it can be used as a key building block for functional materials. After chemical modification and polymerization, polymer materials with special photoelectric properties are prepared, such as for organic Light Emitting Diode (OLED), which can improve the luminous efficiency and stability of devices, and contribute to the development of display technology.
Furthermore, in organic synthetic chemistry, it is an important building block for building complex organic molecules. With its active reaction check point, it can participate in a variety of organic reactions, such as nucleophilic substitution, metal catalytic coupling, etc., to achieve efficient synthesis of complex structural organic compounds, providing a powerful tool for the development of organic synthetic chemistry.

2% 2C5-difluorobenzo [d] thiazole is an organic compound. Its physical properties are quite unique. It is mostly solid at room temperature and pressure, and its stability is very good. The melting point of this compound is quite high, about 80-85 ° C. This characteristic makes it stable in many high temperature reaction environments, and it is not easy to decompose.
Furthermore, 2% 2C5-difluorobenzo [d] thiazole is insoluble in water, but soluble in common organic solvents such as ethanol, ether, chloroform, etc. This solubility characteristic makes it widely used in the field of organic synthesis. Because it can be uniformly dispersed with the help of organic solvents, and then participate in various complex chemical reactions, it greatly expands its application scope in chemical preparation processes.
In addition, the compound has a certain degree of volatility, but compared with some low-boiling organic compounds, its volatility is weaker. Under normal storage and use conditions, there is less volatilization loss, so the storage environment requirements are relatively not strict. As long as it is stored in a cool, dry and well-ventilated place, it can effectively prevent losses caused by volatilization and ensure the stability of its chemical properties and quality.
In conclusion, the unique physical properties of 2% 2C5 -difluorobenzo [d] thiazole have laid a solid foundation for its application in many fields such as organic synthesis and medicinal chemistry, and are of great research and development value.

2% 2C5 -difluorobenzo [d] -azole, this is an organic compound. Its chemical properties are particularly important and have applications in many fields.
From the structural point of view, the compound contains benzoxazole core structure, and fluorine atoms are introduced at the 2nd and 5th positions. The introduction of fluorine atoms greatly affects its physical and chemical properties. First, fluorine atoms have high electronegativity and can enhance the polarity of molecules. This makes the compound soluble in polar solvents or changes. In some reactions, the change of polarity can affect the reactivity and selectivity.
Second, the stability of this compound is quite high. The structure of benzoxazole itself has certain aromaticity, which endows the molecule with certain thermal and chemical stability. The fluorine atom is connected to the benzene ring, and the stability of the molecule is further enhanced through induction effect and conjugation effect. This makes 2% 2C5 -difluorobenzo [d] -azole can maintain the relative stability of the structure under extreme conditions such as high temperature, strong acid, and strong base.
Third, in terms of chemical reactivity, due to its structure and electron cloud distribution characteristics, it can participate in a variety of organic reactions. For example, electrophilic substitution reactions can occur on its benzene ring, and the electron cloud density of the neighboring fluorine atom and the para-position is relatively low, making it more vulnerable to electrophilic attack. In addition, the nitrogen and oxygen atoms on the benzoxazole ring have certain solitary pairs of electrons, which can be used as electron donors to participate in coordination reactions and form complexes with metal ions. This property may have potential applications in the field of catalysis.
Fourth, the chemical properties of this compound also determine its application prospects in materials science, medicinal chemistry and other fields. In materials science, due to the characteristics of stability and polarity, it can be used to prepare high-performance polymer materials and improve the thermal stability and mechanical properties of materials. In the field of medicinal chemistry, the introduction of fluorine atoms often changes the fat solubility and metabolic stability of drug molecules. 2% 2C5 -difluorobenzo [d] -azole may be used as a key structural unit for the design and synthesis of new drugs.

There are several methods for the synthesis of 2% 2C5-difluorobenzo [d] -azole:
First, the anthracinophenol compound is used as the starting material. First, the anthracinophenol reacts with the haloacetate under basic conditions to generate the corresponding benzoxazolinone intermediate. For example, benzoxolinone can be obtained by heating the anthracinophenol with ethyl chloroacetate in the presence of basic substances such as potassium carbonate in a suitable solvent such as N, N-dimethylformamide (DMF). Subsequently, the intermediate is fluorinated by fluorinating reagents such as Selectfluor, etc., and finally 2,5-difluorobenzo [d] -azole is obtained. The advantage of this method is that the starting materials are relatively common and the reaction steps are relatively clear, but the fluorination step may require precise control of the reaction conditions to improve the yield and selectivity.
Second, phenolic compounds are used as the starting materials. Phenolic compounds are first acylated with fluorine-containing acylating reagents to construct fluorine-containing phenol ester structures. For example, phenol and fluorine-containing acyl chloride are catalyzed by organic bases such as pyridine. Afterwards, under dehydrating agent and high temperature conditions, the inner ring of the molecule is promoted to form a benzoxazole structure, and fluorine atoms are introduced to obtain the target product. The method can be used to construct an azole ring and introduce fluorine atoms in one step, but the reaction conditions are relatively harsh, the requirements for dehydrating agent and temperature control are strict, and the selection and preparation of acylating reagents may be difficult.
Third, the coupling reaction is catalyzed by transition metals. The coupling reaction is carried out with fluorinated halogenated aromatics and heterocyclic precursors containing nitrogen and oxygen as raw materials under the action of transition metal catalysts such as palladium catalysts. For example, the reaction of 2-halo-5-fluorobenzene with suitable nitrogen-containing and heterocyclic precursors in an organic solvent in the presence of a catalyst such as tetra (triphenylphosphine) palladium and a base produces 2,5-difluorobenzo [d] -azole through a series of complex reaction processes. This method uses transition metal catalysis to achieve good reaction selectivity, but the catalyst cost is high, the reaction system is relatively complex, and the post-treatment is relatively cumbersome.

The price of 2% 2C5 -difluorobenzo [d] thiazole in the market often varies for many reasons. The key here is quality. Those with good quality will have a high price; if the quality is slightly inferior, the price will also drop.
Furthermore, the influence of supply and demand is quite large. If there are many people in the market, and the supply is limited, the price will rise; on the contrary, if the supply exceeds the demand, the price will drop.
In addition, the cost of production also affects the price. The price of raw materials, the simplicity of the process, and the amount of energy consumption are all related to cost. High cost, high selling price.
Now in the market, the price of 2% 2C5 -difluorobenzo [d] thiazole may be around tens of yuan to hundreds of yuan per gram. However, this is only an approximation, and the actual price may vary depending on time, place and transaction conditions. To obtain a definite price, you should consult the relevant suppliers, or check it carefully on the chemical trading platform to know the exact price at present.