2-[4-(pyrrolidin-1-ylsulfonyl)phenyl]-1,3-benzothiazole

2-%5B4-%28pyrrolidin-1-ylsulfonyl%29phenyl%5D-1%2C3-benzothiazole, organic compounds are also. Its chemical structure is quite interesting, and it is described in ancient Chinese.
This compound contains the core of benzothiazole, which is connected with a phenyl group at 2 positions, and the 4 positions of this phenyl group are substituted by pyrrolidine-1 -ylsulfonyl. Benzothiazole, which is fused from a benzene ring and a thiazole ring, has a unique conjugate system and is useful in many organic reactions and materials.
The phenyl group connected is an aromatic hydrocarbon group, which can increase the stability and hydrophobicity of molecules. The pyrrolidine-1-ylsulfonyl group at the 4-position of phenyl group is a nitrogen-containing five-membered heterocycle with certain alkalinity and nucleophilicity; the sulfonyl group imparts good solubility and electronic effects to the molecule. The two are connected, and the pyrrolidine-1-ylsulfonyl group formed is connected to the 4-position of phenyl group, which has a great impact on the physical and chemical properties of the molecule.
Its overall structure makes the compound have specific biological activities, optical properties or other functional properties. In the field of organic synthesis, this structure can be constructed by a variety of reaction paths, and each step of the reaction needs to be carefully regulated to obtain a pure target product. Viewing its structure, it is like a delicate chemical puzzle, with each part cooperating to endow the compound with unique properties and potential application value.

2-%5B4-%28pyrrolidin-1-ylsulfonyl%29phenyl%5D-1%2C3-benzothiazole is an organic compound. It has many physical properties.
Looking at its properties, it may be a solid under normal conditions. Due to the strong forces between molecules, such as van der Waals forces and hydrogen bonds, the molecules are closely arranged and appear in a solid state.
When it comes to the melting point, the benzothiazole ring in the molecular structure is connected to the pyrrolidinyl sulfonic phenyl group, forming a rigid structure, and the interaction between molecules is enhanced, so the melting point is relatively high. This rigid structure makes the molecules need more energy to overcome the mutual forces and realize the transition from solid to liquid.
In terms of solubility, the compound has a certain solubility in polar organic solvents such as dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF) due to its polar sulfone group. However, the overall non-polar part of the molecule is also large, and the solubility in water is not good. Because water is a strong polar solvent, it does not match the intermolecular force of the compound, making it difficult to disperse and dissolve effectively.
When it comes to density, because of the specific types and quantities of atoms in the molecular structure, the sum of atomic weights and the arrangement of molecular space determine its density. The compact structure of benzothiazole ring and substituted phenyl group makes it relatively dense. The specific value is related to the precise structure of the molecule and the way of crystal accumulation.
In addition, the compound may have certain stability, and the structure of benzothiazole ring and sulfone group gives it relatively stable chemical properties. However, under specific conditions, such as high temperature, strong acid and alkali environment, some chemical bonds in its structure may be broken, resulting in chemical properties changes.

2-%5B4-%28pyrrolidin-1-ylsulfonyl%29phenyl%5D-1%2C3-benzothiazole, this is an organic compound. Its use is quite critical, commonly found in the field of medicinal chemistry, and plays an important role.
In the process of drug development, such compounds often exhibit unique biological activities. Due to the specific groups in the structure, it may interact with specific targets in organisms. For example, in the drug screening process for certain diseases, 2-%5B4-%28pyrrolidin-1-ylsulfonyl%29phenyl%5D-1%2C3-benzothiazole or by virtue of its structural characteristics, it precisely binds to disease-related proteins, enzymes and other targets, and then affects the disease process. Maybe it can regulate the activity of enzymes, bring abnormal biochemical reactions back on track; or intervene in protein interactions and inhibit harmful cell activities.
In addition, in the field of materials science, it may also be useful. With its special structure, it can be used as a key component of functional materials. For example, it is used to prepare materials with specific optical and electrical properties, which adds to the development of the material field.
However, when applying this compound, many factors need to be paid attention to. Physical and chemical properties such as its solubility and stability will affect the actual application effect. If the solubility is not good, it may be difficult to disperse effectively in pharmaceutical preparations, hindering its efficacy; insufficient stability, it is easy to change during storage and use, weakening its original properties. Only by taking these factors into account can 2-%5B4-%28pyrrolidin-1-ylsulfonyl%29phenyl%5D-1%2C3-benzothiazole be properly applied in various fields and give full play to its value.

To prepare 2- [4- (pyrrolidine-1-ylsulfonyl) phenyl] -1,3-benzothiazole, follow the following ancient method.
First take an appropriate amount of 4-halogenated benzenesulfonyl chloride, place it in a kettle with pyrrolidine, add an appropriate amount of acid binding agent, such as triethylamine, control the temperature in a moderate range, about 30 to 50 degrees Celsius, stir it to give 4- (pyrrolidine-1-ylsulfonyl) benzenesulfonyl chloride. In this step, the acid binding agent can remove the acid generated by the reaction and promote the reaction to move to the right.
After taking o-aminothiophenol, dissolve it into an appropriate solvent, such as dichloromethane, and then add the 4- (pyrrolidine-1-ylsulfonyl) benzenesulfonyl chloride obtained above into it. Add a base to assist the reaction, such as potassium carbonate, and keep stirring at room temperature to 40 degrees Celsius. In this process, the base can catalyze the condensation of the two, and the reaction is completed after a few hours. After
, pour the reaction solution into water, extract with an organic solvent, such as ethyl acetate, separate the organic phase, dry it with anhydrous sodium sulfate, remove the solvent, and then purify it by column chromatography or recrystallization to obtain pure 2- [4- (pyrrolidine-1-ylsulfonyl) phenyl] -1,3-benzothiazole. During column chromatography, select the appropriate eluent and separate it according to the polarity of the product and impurities; for recrystallization, select the appropriate solvent to dissolve the product when hot and precipitate when cold to achieve the effect of purification.

2-%5B4-%28pyrrolidin-1-ylsulfonyl%29phenyl%5D-1%2C3-benzothiazole is an organic compound. During use, the following numbers should be paid attention to:
First, this substance has specific chemical activity. When operating, safety procedures must be strictly followed. Do not let the skin or eyes come into contact with it. If you accidentally touch it, you need to rinse it with a lot of water immediately and seek medical attention as appropriate.
Second, because its structure contains benzothiazole and sulfonyl groups, its chemical properties may cause reactions with other substances. Before use, be sure to know its chemical properties in detail to avoid mixing and mixing with incompatible chemicals to prevent dangerous reactions.
Third, when storing, it should be placed in a cool, dry and well-ventilated place, away from fire sources and oxidants.
Fourth, in view of the organic compounds or biological activity, in the laboratory environment, the waste after use should be properly disposed of in accordance with regulations, do not dump at will, so as not to pollute the environment.
Fifth, when handling this substance, it should be carried out in a fume hood to prevent inhalation of its volatile gaseous substances. If used in an environment without adequate ventilation equipment, gaseous substances may accumulate or cause health damage.
Sixth, before use, the experimenter should be familiar with the relevant information of the compound, including safety data, physical and chemical properties, etc., in order to ensure safety. When operating, appropriate protective equipment, such as laboratory clothes, gloves, goggles, etc.