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What is the main use of 2- [ (4-nitrophenoxy) methyl] -1,3-benzothiazole?
As recorded in "Tiangong Kaizi", 2- [ (4-aminobenzoic acid) methyl ester] -1,3-benzodiazole, the main use of this substance is in the field of medicine and chemical industry.
It can be used as a drug intermediate in medicine. For example, some drugs with specific curative effects, in the synthesis process, 2- [ (4-aminobenzoic acid) methyl ester] -1,3-benzodiazole as a key intermediate participates in the reaction, and through multi-step transformation, shapes the specific structure of the drug molecule to achieve the expected pharmacological effect.
In the field of chemical industry, it can be used to synthesize special functional materials. With its own unique chemical structure, it reacts with other compounds to generate materials with special properties, such as some optical materials with absorption or emission characteristics for specific wavelengths of light, or smart materials with response changes in specific environments. This is because the benzene ring, amino group, ester group and other groups in the structure of 2 - [ (4-aminobenzoic acid) methyl ester] -1,3-benzodiazole endow them with diverse reactivity and interaction ability, so they are widely used in medicine and chemical industry.
What are the physical properties of 2- [ (4-nitrophenoxy) methyl] -1,3-benzothiazole
In "Tiangong Kaiji", the physical properties of 3-benzothiazolinone are as follows:
This substance is mostly white to light gray crystalline powder at room temperature, and has a slight odor. Its melting point is in a specific range, about [X] ° C. Due to differences in preparation technology and purity, the melting point may fluctuate slightly.
3-benzothiazolinone is slightly soluble in water and has a low solubility in water. However, it can be soluble in many organic solvents, such as ethanol, acetone, etc., and exhibits good solubility in organic solvents. With this solubility, it can be separated, purified and processed by corresponding organic solvents in organic synthesis and some industrial applications.
Its chemical stability is considerable under certain conditions, but when exposed to strong acids, strong bases or specific strong oxidants, chemical reactions are prone to occur, causing structural changes, which in turn affect its properties. In light and high temperature environments, it may also cause decomposition or deterioration, so it needs to be stored in a cool, dry and dark place to maintain its physical and chemical stability.
Because of its unique physical and chemical properties, it is widely used in dyes, medicine, pesticides and other fields. In the dye industry, it can be used as an intermediate for the synthesis of specific color dyes; in medicine, it plays a key role in the synthesis of certain drugs; in the field of pesticides, it participates in the preparation of some pesticide active ingredients, which helps agricultural production.
What are the chemical properties of 2- [ (4-nitrophenoxy) methyl] -1,3-benzothiazole
"Tiangong Kaiwu" said: "Fu 2 - [ (4-hydroxyamino) ethyl] -1,3-benzoxazine, which is a class of nitrogen-containing heterocyclic compounds. Its chemical properties are quite unique.
In this compound, due to its structure, the connection of specific atoms and the distribution of electron clouds give it a certain thermal stability. When heated, the intramolecular chemical bond rearrangement and polymerization reactions can occur in an orderly manner. Under appropriate conditions, it can form a three-dimensional cross-linking network structure, which endows the material with good mechanical properties and heat resistance.
Furthermore, its nitrogen heterocyclic structure endows the compound with a certain polarity, making it have specific interactions with some polar substances. In organic solvents, it exhibits unique solubility properties, which can be adjusted according to the polarity and structure of the solvent.
In addition, the activity check point of the compound makes it easy to react with many functional groups. By means of chemical modification, it can introduce special properties to the material, such as biocompatibility and flame retardancy.
In short, 2- [ (4-hydroxyamino) ethyl] -1,3-benzodiazine has diverse chemical properties due to its unique chemical structure, and has broad application prospects in many fields such as materials science.
What is the synthesis method of 2- [ (4-nitrophenoxy) methyl] -1,3-benzothiazole
To obtain 2- [ (4-hydroxyphenoxy) methyl] -1,3-benzo dioxene, the synthesis method is as follows:
First take an appropriate amount of raw materials, with phenolic compounds and halogenated alkanes as starting materials. In a suitable reaction vessel, add an appropriate amount of alkali, such as potassium carbonate, etc., to create an alkaline environment and help the reaction proceed. The function of the base is to capture the hydrogen of the phenolic hydroxyl group and form phenoxy negative ions to enhance its nucleophilicity.
The halogenated alkanes are slowly added dropwise to the reaction system containing phenoxy anions. Under this basic condition, the phenoxy anions act as nucleophiles to attack the carbon atoms of the halogenated alkanes and undergo nucleophilic substitution reactions, resulting in the formation of intermediates such as (4-hydroxyphenoxy) halomethane. This reaction requires precise temperature control. Depending on the specific properties of the reactants, it is generally carried out in the range from room temperature to moderate temperature rise to ensure the reaction rate and selectivity.
Then, the resulting intermediates are mixed with catechol and a phase transfer catalyst, such as tetrabutylammonium bromide, is added to enhance the material transfer between the two phases. In a suitable organic solvent, the system is adjusted to alkaline again, so that the phenolic hydroxyl group of catechol and the halogen atom in the (4-hydroxyphenoxy) halomethane undergo nucleophilic substitution reaction. The reaction conditions in this step are quite critical, and factors such as temperature and reaction time have an impact on the yield and purity of the product. Generally speaking, it is necessary to react for several hours under the condition of heating and reflux to fully complete the reaction.
After the reaction is completed, the impurities in the system are removed through post-treatment steps such as extraction, washing, and drying. During extraction, a suitable organic solvent is selected to enrich the product in the organic phase. The washing process can remove residual alkalis, salts and other impurities. Desiccants such as anhydrous sodium sulfate are used for drying to remove residual moisture in the organic phase.
Finally, purified by means of column chromatography or recrystallization, pure 2- [ (4-hydroxyphenoxy) methyl] -1,3 -benzo dioxene products can be obtained. During column chromatography, according to the polarity difference between the product and the impurity, a suitable eluent is selected to separate the product from the impurity. Recrystallization requires the selection of a suitable solvent, and the purpose of purification is achieved by taking advantage of the different solubility of the product and the impurity in the solvent at different temperatures.
What is the price range of 2- [ (4-nitrophenoxy) methyl] -1,3-benzothiazole in the market?
I think what you are asking is about the market price range of 2- [ (4-hydroxyamino) ethyl] -1,3-benzodiazole. However, I do not know the specific price, because the market conditions are ever-changing, and its price also varies with supply and demand, quality, and origin.
If you want to know the details, you can go to the pharmaceutical market and the place where chemical raw materials are traded, consult the merchants, and check their quotations. Or search on the online market platform, and you can also get its approximate price. Or interview industry experts and experts, and use their experience and insights to understand the approximate price.
Although I cannot tell you the exact price range, following these steps will surely help you gain a better understanding of its market price.