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What are the physical properties of 2- (4-methylphenyl) -1,3-benzothiazole?
2-% 284 - methylphenyl% 29 - 1% 2C3 - benzothiazole is 2 - (4 - methylphenyl) - 1,3 - benzothiazole. The physical properties of this substance are as follows:
It is usually in a solid state, and its appearance may be a crystalline powder. Due to the interaction between molecules, it forms a regular arrangement and presents a solid state.
The melting point is the key physical quantity for measuring its transformation from solid to liquid state. 2 - (4 - methylphenyl) - 1,3 - benzothiazole has a specific melting point, but the specific value will vary slightly depending on the purity of the sample and the test conditions. In general, the higher the purity, the closer the melting point to the theoretical value.
The boiling point is also an important physical property, which is the temperature at which a substance changes from liquid to gaseous state, reflecting the strength of intermolecular forces. The boiling point of 2 - (4 - methylphenyl) -1,3 - benzothiazole depends on the chemical bonds between atoms and the intermolecular forces in the molecular structure, and is also affected by the purity and testing environment.
In terms of solubility, it is different from the solubility of organic solvents. In some organic solvents such as ethanol and dichloromethane, it may exhibit some solubility. Because of the specific interactions between molecules and solvent molecules, such as van der Waals force, hydrogen bond, etc., it can promote dissolution. However, the solubility in water is not good. Due to the molecular structure of the substance having a certain hydrophobicity, the interaction between water molecules and solute molecules is weak, making it difficult for the solute to disperse uniformly in water.
Density is regarded as the mass per unit volume, and the density of 2- (4-methylphenyl) -1,3-benzothiazole is closely related to the molecular structure. The density of the structure determines the mass contained in the unit volume, which is of great significance for its practical application involving mixing, separation and other operations.
In addition, the substance may have a specific refractive index, which reflects the change of light propagation speed and direction in it, and is related to the molecular structure of the substance and the distribution of electron clouds. It provides an important basis for the identification and analysis of the substance.
What are the main uses of 2- (4-methylphenyl) -1,3-benzothiazole?
2-%284-methylphenyl%29-1%2C3-benzothiazole is 2- (4-methylphenyl) -1,3-benzothiazole, which has a wide range of uses. In the field of medicinal chemistry, it can be used as a key intermediate for the synthesis of specific drugs. The compound has a unique chemical structure and biological activity. After chemical modification and modification, it may be able to derive drug molecules with specific pharmacological activities, or have antibacterial, anti-inflammatory and even anti-tumor effects, making great contributions to human health.
In the field of materials science, it also shows extraordinary value. It can be used to prepare organic materials with unique functions, such as organic Light Emitting Diode (OLED) materials. Due to its molecular structure endowing special optoelectronic properties, it may improve the luminous efficiency and stability of OLED devices, contributing to the development of display technology. In addition, in the preparation of high-performance sensor materials, 2- (4-methylphenyl) -1,3-benzothiazole has a significant role in the field of environmental monitoring due to its ability to selectively identify and respond to specific substances, or to accurately detect certain harmful substances in the environment.
In the field of organic synthesis, 2- (4-methylphenyl) -1,3-benzothiazole is often used as an important structural unit. Organic chemists can use various chemical reactions to cleverly connect them with other organic molecules, build complex and diverse organic compounds, enrich the variety and properties of organic compounds, and inject vitality into the progress of organic synthetic chemistry.
What are the synthesis methods of 2- (4-methylphenyl) -1,3-benzothiazole?
To prepare 2 - (4 - methylphenyl) - 1, 3 - benzothiazole, there are many methods, and each has its advantages and disadvantages, so it needs to be selected according to the facts.
First, 4 - methylthiophenol and anthranilic acid can be prepared by condensation and cyclization. First, 4 - methylthiophenol and anthranilic acid are mixed in a suitable solvent in proportion, such as toluene or xylene, and an appropriate amount of catalyst, such as concentrated sulfuric acid or p-toluenesulfonic acid, is added. During the reaction, the sulfur atom in 4 - methylthiophenol is condensed with the carboxyl group of anthranilic acid, and the amino group reacts with another part to form a ring to obtain the target product. This process requires temperature control at 150-200 ° C, and the reaction time is about 6-10 hours. The raw materials of this method are easy to prepare, and the operation is not complicated. However, the reaction conditions are harsh and the yield may be limited.
Second, 4-methylbenzaldehyde and 2-aminothiophenol are used as materials and condensed in acidic medium. Dissolve the two in a specific ratio into ethanol or ethyl acetate, and add a little hydrochloric acid or sulfuric acid to catalyze. 4-Methylbenzaldehyde carbonyl is condensed with 2-aminothiophenol amino, and then 2- (4-methylphenyl) -1,3-benzothiazole is obtained by intramolecular cyclization. The reaction temperature should be controlled at 60-80 ℃ for 4-8 hours. The reaction conditions of this method are mild and the yield is high, but the stability of the raw material 4-methylbenzaldehyde is not good, and the preservation and use need to be cautious.
Another method uses halogenated aromatics and thiourea as starting materials. First, the halogenated aromatics, such as 4-methylbenzyl chloride, react with thiourea under basic conditions to form intermediates, and then the intermediates are cyclized at high temperature to obtain the target. This way of raw materials is inexpensive, but there are many reaction steps, which require fine operation to ensure the purity and yield of the product.
What is the price range of 2- (4-methylphenyl) -1,3-benzothiazole in the market?
I do not know the price range of 2- (4-methylphenyl) -1,3-benzothiazole in the market. The price of this product often varies due to various reasons, such as differences in quality, purchase quantity, purchase location, and market supply and demand. Or in the market of chemical raw materials, its price is determined by the cost of raw materials and the difficulty of production process; in the field of scientific research reagents, the quality and purity requirements are very high, and its price is also different. To know the price, you can consult the supplier of chemical raw materials, the seller of reagents, or visit the relevant chemical product trading platform to carefully observe the recent trading conditions, and then you can get a more accurate price range.
What are the precautions during the use of 2- (4-methylphenyl) -1,3-benzothiazole?
2-% 284 - methylphenyl% 29 - 1% 2C3 - benzothiazole is also a chemical substance. In the process of use, it is necessary to pay more attention and must not be ignored.
First, this substance has chemical activity, and it should be handled with caution. It is appropriate to use it in a good place to prevent its substances from gathering in the room, causing air staining and harming the person. If it is used in dense air, it will be tiring, or there will be an accident.
For the second time, it is indispensable to use this substance. Wear gloves that are resistant to chemical corrosion, so as not to connect the skin. If the skin is damaged, it may cause sensitivity, burning and other diseases.
In addition, it should be stored properly. It should be placed in the dark and dry areas to avoid the source of fire. Because of its flammability, it may encounter open flames and high temperatures, and it is necessary to store oxidizing, acid and other substances separately to prevent them from disintegrating and reacting.
In addition, the equipment used must be used. Keep this thing, or use it next time, or rot the equipment. Cleaning liquid, according to its chemical properties, so that the equipment can be kept, so that the security can be improved.
Therefore, 2-% 284 - methylphenyl% 29 - 1% 2C3 - benzothiazole is used. All precautions must be followed to ensure safe operation and avoid production.