2-(4-METHOXYPHENYL)-1,3-THIAZOLE-4-CARBALDEHYDE

2-% (4-methoxybenzyl) -1,3-ethoxazole-4-acetonitrile has a wide range of uses. As a key intermediate in the field of organic synthesis, it can participate in the construction of many complex organic compounds. For example, in pharmaceutical chemistry, it can be converted into drug molecules with specific pharmacological activities through a series of reactions. Due to its unique chemical structure, methoxybenzyl and groups such as ethoxazole and acetonitrile endow it with special reactivity and spatial configuration, which is conducive to nucleophilic substitution and electrophilic addition with other reagents, thereby deriving diverse compound structures.
also has important applications in the field of materials science. After appropriate modification and polymerization, polymer materials with special properties can be prepared, such as materials with specific optical, electrical or thermal properties. For example, in the field of optoelectronic materials, it is possible to design and optimize their structures, so that the resulting materials exhibit excellent properties in luminescence, electrical conductivity, etc., providing a basis for the development of new optoelectronic devices.
In addition, in the study of total synthesis of natural products, it is often used as a starting material or a key intermediate to help realize the artificial synthesis of natural products with complex structures, laying a material foundation for in-depth research on the biological activity and pharmacological effects of natural products. Overall, 2-% (4-methoxybenzyl) -1,3-oxazole-4-acetonitrile plays an indispensable role in many fields such as organic synthesis, materials science, and total synthesis of natural products, and is of great significance for promoting scientific research and technological development in related fields.

"Tiangong Kaiwu" is a masterpiece of ancient science and technology in our country, in which many material properties are delicately described. Today, the physical properties of ethane are described in ancient Chinese.
Ethane is a colorless and odorless gas at room temperature and pressure. Its density is slightly lighter than that of air. This property makes ethane float in the upper layer of air if it escapes in open space. Ethane is extremely difficult to dissolve in water, and its solubility in water is extremely low, just like the difficulty of oil and water.
Furthermore, the boiling point of ethane is quite low, about -88.6 ° C, which means that if the temperature drops slightly, it is easy to change from a gaseous state to a liquid state. Its melting point is even lower, about -183.3 ° C. When the temperature drops to this temperature, ethane will solidify into a solid state.
Looking at its flammability, ethane is very easy to burn. When exposed to open flames and hot topics in the air, it will burn violently, generating carbon dioxide and water, and releasing a lot of heat. This property also makes it often used as a fuel.
Ethane vapor and air can form explosive mixtures, which can cause combustion and explosion when exposed to open flames and high heat. This is why it needs special vigilance when used and stored.
In summary, ethane has physical properties such as colorless and odorless, slightly lighter density than air, insoluble in water, low boiling point and melting point, flammable, and explosive when mixed with steam and air. When used, it should be treated with caution, make good use of its advantages, and avoid its risks.

To prepare 2 - (4 - methoxybenzyl) - 1,3 - dialkane - 4 - formaldehyde, the synthesis method is as follows:
The first method is to use p-methoxybenzyl alcohol and halogenated acetaldehyde diethyl acetal as raw materials. Take p-methoxybenzyl alcohol first, add an appropriate amount of alkali, such as potassium carbonate, in an appropriate reaction vessel, as a catalyst. Then slowly add halogenated acetaldehyde diethyl acetal, control the temperature to a suitable range, about 40-60 degrees Celsius, and continue to stir. During the process, the halogen atom of the halogenated acetaldehyde diethyl acetal undergoes a nucleophilic substitution reaction with the hydroxyl group of p-methoxybenzyl alcohol, and gradually generates the precursor of 2- (4-methoxybenzyl) -1,3-dialkane-4-formaldehyde. Then, after subsequent treatment such as hydrolysis, the target product can be obtained. The raw materials of this route are relatively easy to obtain, the reaction conditions are relatively mild, and the operation is convenient.
can also be used with p-methoxybenzaldehyde and ethylene glycol as starting materials. First, the p-methoxybenzaldehyde is mixed with ethylene glycol, and the p-toluenesulfonic acid is used as the catalyst. In the presence of water-carrying agents such as toluene, it is heated and refluxed The carbonyl group of p-methoxybenzaldehyde reacts with the two hydroxyl groups of ethylene glycol to form a cyclic acetal structure, namely 2- (4-methoxybenzyl) -1,3-dialkane-4-formaldehyde. In this process, the water carrier can remove the water generated by the reaction in time, promote the positive shift of the reaction equilibrium, and improve the yield. The method has good atomic economy and relatively simple product separation.
Another way is to use 4-methoxybenzyl halide and 2-hydroxyacetal diethyl acetal as raw materials. Under the catalysis of organic bases such as triethylamine, the halogen atom of 4-methoxybenzyl halide reacts with the hydroxyl group of 2-hydroxyacetaldehyde diethyl acetal to form the basic skeleton of the target product. After subsequent steps such as deprotection, pure 2- (4-methoxybenzyl) -1,3-dialkane-4-formaldehyde can be obtained. This method requires attention to the activity and reaction selectivity of the halide, and precise control of the reaction conditions to obtain satisfactory results.

What you are asking is about the market price of 2 - (4 - acetylbenzyl) - 1,3 - dialkane - 4 - acetic acid. This is a key question in the field of fine chemicals, which concerns many chemical production and scientific research applications.
In today's market, prices fluctuate and are subject to many factors. First, the supply and price of raw materials. The synthesis of this compound requires specific raw materials. If the origin of raw materials changes, production increases or decreases, or in case of trade policy adjustments, the cost can fluctuate, which in turn affects the price of the product. Second, the market demand situation. If the downstream industry, such as medicine, materials and other fields, has a surge in demand and the supply exceeds the demand, the price will rise; conversely, the demand will be sluggish, the supply will exceed the demand, and the price may drop. Third, the advantages and disadvantages of the production process and the cost, efficient and low-cost process, can make the product price competitive in the market; complex and high-cost process, will lead to higher prices.
However, after searching all kinds of market information, chemical trading platforms and related industry reports, the exact price cannot be obtained. Because the market is complex and changeable, and the product specifications and purity of different manufacturers are different, the price is also very different. If you want to know the exact market price, you should communicate with industry suppliers and distributors in detail, or participate in chemical product exhibitions and seminars to gather information, in order to obtain a relatively accurate price range to meet the needs of production and procurement.

There is a question today: What are the precautions for the storage and transportation of 2 - (4 - methoxybenzyl) - 1,3 - pentadiene - 4 - methyne? Answer: Methyne and the like are lively in nature, and many matters need to be handled with caution during storage and transportation.
In terms of storage, the first choice of environment. It should be placed in a cool and ventilated warehouse, away from fire and heat sources. This is because methyne is flammable, high temperature and open flame can be dangerous. The temperature of the warehouse should be controlled within a reasonable range to prevent the reaction of substances from being exacerbated due to excessive temperature. And should be stored separately from oxidizing agents, acids, alkalis, etc., not mixed storage, because methyne and other such substances are prone to chemical reactions, causing danger.
As for transportation, transport vehicles must ensure good safety devices. During transportation, it should be properly fixed to prevent the container from shaking, colliding, causing package damage and leakage. During transportation, drivers and passengers must pay close attention to the status of the goods, and must not stay in dangerous areas such as densely populated areas and near fire sources. At the same time, transport personnel should be familiar with the characteristics of methyne and emergency treatment methods. In case of emergencies, they can respond quickly and correctly.
In addition, whether it is storage or transportation, the relevant places and vehicles should be equipped with suitable fire fighting equipment and leakage emergency treatment equipment, so that in the event of an accident, rescue and treatment can be carried out in time to minimize the harm. In short, the storage and transportation of 2 - (4-methoxybenzyl) -1,3-pentadiene-4-methyne should be treated with a rigorous and scientific attitude to ensure the safety of the whole process.